Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Birth order and childhood type 1 diabetes risk
T2 - a pooled analysis of 31 observational studies
AU - Cardwell, Chris R.
AU - Stene, Lars C.
AU - Joner, Geir
AU - Bulsara, Max K.
AU - Cinek, Ondrej
AU - Rosenbauer, Joachim
AU - Ludvigsson, Johnny
AU - Svensson, Jannet
AU - Goldacre, Michael J.
AU - Waldhoer, Thomas
AU - Jarosz-Chobot, Przemyslawa
AU - Gimeno, Suely G. A.
AU - Chuang, Lee-Ming
AU - Roberts, Christine L.
AU - Parslow, Roger C.
AU - Wadsworth, Emma J. K.
AU - Chetwynd, Amanda
AU - Brigis, Girts
AU - Urbonaite, Brone
AU - Sipetic, Sandra
AU - Schober, Edith
AU - Devoti, Gabriele
AU - Ionescu-Tirgoviste, Constantin
AU - de Beaufort, Carine E.
AU - Stoyanov, Denka
AU - Buschard, Karsten
AU - Radon, Katja
AU - Glatthaar, Christopher
AU - Patterson, Chris C.
PY - 2011/4
Y1 - 2011/4
N2 - Background The incidence rates of childhood onset type 1 diabetes are almost universally increasing across the globe but the aetiology of the disease remains largely unknown. We investigated whether birth order is associated with the risk of childhood diabetes by performing a pooled analysis of previous studies.Methods Relevant studies published before January 2010 were identified from MEDLINE, Web of Science and EMBASE. Authors of studies provided individual patient data or conducted pre-specified analyses. Meta-analysis techniques were used to derive combined odds ratios (ORs), before and after adjustment for confounders, and investigate heterogeneity.Results Data were available for 6 cohort and 25 case-control studies, including 11 955 cases of type 1 diabetes. Overall, there was no evidence of an association prior to adjustment for confounders. After adjustment for maternal age at birth and other confounders, a reduction in the risk of diabetes in second- or later born children became apparent [fully adjusted OR = 0.90 95% confidence interval (CI) 0.83-0.98; P = 0.02] but this association varied markedly between studies (I-2 = 67%). An a priori subgroup analysis showed that the association was stronger and more consistent in children < 5 years of age (n = 25 studies, maternal age adjusted OR = 0.84 95% CI 0.75, 0.93; I-2 = 23%).Conclusion Although the association varied between studies, there was some evidence of a lower risk of childhood onset type 1 diabetes with increasing birth order, particularly in children aged < 5 years. This finding could reflect increased exposure to infections in early life in later born children.
AB - Background The incidence rates of childhood onset type 1 diabetes are almost universally increasing across the globe but the aetiology of the disease remains largely unknown. We investigated whether birth order is associated with the risk of childhood diabetes by performing a pooled analysis of previous studies.Methods Relevant studies published before January 2010 were identified from MEDLINE, Web of Science and EMBASE. Authors of studies provided individual patient data or conducted pre-specified analyses. Meta-analysis techniques were used to derive combined odds ratios (ORs), before and after adjustment for confounders, and investigate heterogeneity.Results Data were available for 6 cohort and 25 case-control studies, including 11 955 cases of type 1 diabetes. Overall, there was no evidence of an association prior to adjustment for confounders. After adjustment for maternal age at birth and other confounders, a reduction in the risk of diabetes in second- or later born children became apparent [fully adjusted OR = 0.90 95% confidence interval (CI) 0.83-0.98; P = 0.02] but this association varied markedly between studies (I-2 = 67%). An a priori subgroup analysis showed that the association was stronger and more consistent in children < 5 years of age (n = 25 studies, maternal age adjusted OR = 0.84 95% CI 0.75, 0.93; I-2 = 23%).Conclusion Although the association varied between studies, there was some evidence of a lower risk of childhood onset type 1 diabetes with increasing birth order, particularly in children aged < 5 years. This finding could reflect increased exposure to infections in early life in later born children.
KW - Diabetes mellitus
KW - type 1
KW - epidemiology
KW - birth order
KW - meta-analysis
KW - MATERNAL AGE
KW - EARLY-LIFE
KW - MELLITUS
KW - CHILDREN
KW - DETERMINANTS
KW - ONSET
KW - IDDM
KW - INFECTIONS
KW - DELIVERY
KW - UK
U2 - 10.1093/ije/dyq207
DO - 10.1093/ije/dyq207
M3 - Journal article
VL - 40
SP - 363
EP - 374
JO - International Journal of Epidemiology
JF - International Journal of Epidemiology
IS - 2
ER -