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Boron for tissue regeneration-it’s loading into chitosan/collagen hydrogels and testing on chorioallantoic membrane to study the effect on angiogenesis

Research output: Contribution to journalJournal article

Published
  • S. Ahtzaz
  • T. Sher Waris
  • L. Shahzadi
  • A. Anwar Chaudhry
  • I. Ur Rehman
  • M. Yar
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<mark>Journal publication date</mark>31/03/2020
<mark>Journal</mark>International Journal of Polymeric Materials and Polymeric Biomaterials
Issue number8
Volume69
Number of pages10
Pages (from-to)525-534
Publication StatusPublished
Early online date25/03/19
<mark>Original language</mark>English

Abstract

In the current study, boric acid loaded chitosan (CS) and collagen-based hydrogels were prepared. Hydrogels with four different boric acid concentrations were prepared; control hydrogel (without boric acid), and a hydrogel having boric acid 50 mg (B50), 250 mg boric acid (B250) and 500 mg boric acid (B500). Internal morphology of hydrogel was determined by performing scanning electron microscopy (SEM). Internal linkages of functional groups were confirmed by Fourier transform infrared spectroscopy (FT-IR). The pro-angiogenic potential of these materials was explored in chorioallantoic membrane (CAM) assay and 50 mg boric acid (B50) based hydrogel showed comparatively higher angiogenesis.