Micro-electrode array (MEA) is a widely used platform in biosensor systems, which provide a technology in communicating with micro chemical and biological world. This paper addresses hte topic of testing micro electrode degradation for MEAs, which is a common encountered damage during its application. The basic logic of the proposed test method is examining the symmetrical impedance of the included surrounding electrode by a central stimulating electrode. The feasability was proved by preliminary simulation and the underlaying assumption was confirmed by application experience.