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Cannabinoids mediate opposing effects on inflammation-induced intestinal permeability

Research output: Contribution to journalJournal article

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<mark>Journal publication date</mark>04/2012
<mark>Journal</mark>British Journal of Pharmacology
Issue number8
Volume165
Number of pages13
Pages (from-to)2598-610
Publication statusPublished
Original languageEnglish

Abstract

Activation of cannabinoid receptors decreases emesis, inflammation, gastric acid secretion and intestinal motility. The ability to modulate intestinal permeability in inflammation may be important in therapy aimed at maintaining epithelial barrier integrity. The aim of the present study was to determine whether cannabinoids modulate the increased permeability associated with inflammation in vitro.