Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Cannabinoids mediate opposing effects on inflammation-induced intestinal permeability
AU - Alhamoruni, A.
AU - Wright, Karen
AU - Larvin, M.
AU - O'Sullivan, S. E.
N1 - © 2011 The Authors. British Journal of Pharmacology © 2011 The British Pharmacological Society.
PY - 2012/4
Y1 - 2012/4
N2 - Activation of cannabinoid receptors decreases emesis, inflammation, gastric acid secretion and intestinal motility. The ability to modulate intestinal permeability in inflammation may be important in therapy aimed at maintaining epithelial barrier integrity. The aim of the present study was to determine whether cannabinoids modulate the increased permeability associated with inflammation in vitro.
AB - Activation of cannabinoid receptors decreases emesis, inflammation, gastric acid secretion and intestinal motility. The ability to modulate intestinal permeability in inflammation may be important in therapy aimed at maintaining epithelial barrier integrity. The aim of the present study was to determine whether cannabinoids modulate the increased permeability associated with inflammation in vitro.
KW - intestinal permeability
KW - inflammation
KW - Caco-2 cells
KW - cytokines
KW - transepithelial electrical resistance (TEER)
KW - endocannabinoid
KW - cannabinoid CB1 receptor;Δ9-tetrahydrocannabinol and cannabidiol
UR - http://www.scopus.com/inward/record.url?scp=84859051261&partnerID=8YFLogxK
U2 - 10.1111/j.1476-5381.2011.01589.x
DO - 10.1111/j.1476-5381.2011.01589.x
M3 - Journal article
C2 - 21745190
VL - 165
SP - 2598
EP - 2610
JO - British Journal of Pharmacology
JF - British Journal of Pharmacology
SN - 1476-5381
IS - 8
ER -