Final published version
Licence: CC BY: Creative Commons Attribution 4.0 International License
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - C. elegans Eats Its Own Intestine to Make Yolk Leading to Multiple Senescent Pathologies
AU - Ezcurra, Marina
AU - Benedetto, Alexandre
AU - Sornda, Thanet
AU - Gilliat, Ann F
AU - Au, Catherine
AU - Zhang, Qifeng
AU - van Schelt, Sophie
AU - Petrache, Alexandra L
AU - Wang, Hongyuan
AU - de la Guardia, Yila
AU - Bar-Nun, Shoshana
AU - Tyler, Eleanor
AU - Wakelam, Michael J
AU - Gems, David
N1 - Copyright © 2018 The Author(s). Published by Elsevier Ltd.. All rights reserved.
PY - 2018/8/20
Y1 - 2018/8/20
N2 - Aging (senescence) is characterized by the development of numerous pathologies, some of which limit lifespan. Key to understanding aging is discovery of the mechanisms (etiologies) that cause senescent pathology. In C. elegans, a major senescent pathology of unknown etiology is atrophy of its principal metabolic organ, the intestine. Here we identify a cause of not only this pathology but also of yolky lipid accumulation and redistribution (a form of senescent obesity): autophagy-mediated conversion of intestinal biomass into yolk. Inhibiting intestinal autophagy or vitellogenesis rescues both visceral pathologies and can also extend lifespan. This defines a disease syndrome leading to multimorbidity and contributing to late-life mortality. Activation of gut-to-yolk biomass conversion by insulin/IGF-1 signaling (IIS) promotes reproduction and senescence. This illustrates how major, IIS-promoted senescent pathologies in C. elegans can originate not from damage accumulation but from direct effects of futile, continued action of a wild-type biological program (vitellogenesis).
AB - Aging (senescence) is characterized by the development of numerous pathologies, some of which limit lifespan. Key to understanding aging is discovery of the mechanisms (etiologies) that cause senescent pathology. In C. elegans, a major senescent pathology of unknown etiology is atrophy of its principal metabolic organ, the intestine. Here we identify a cause of not only this pathology but also of yolky lipid accumulation and redistribution (a form of senescent obesity): autophagy-mediated conversion of intestinal biomass into yolk. Inhibiting intestinal autophagy or vitellogenesis rescues both visceral pathologies and can also extend lifespan. This defines a disease syndrome leading to multimorbidity and contributing to late-life mortality. Activation of gut-to-yolk biomass conversion by insulin/IGF-1 signaling (IIS) promotes reproduction and senescence. This illustrates how major, IIS-promoted senescent pathologies in C. elegans can originate not from damage accumulation but from direct effects of futile, continued action of a wild-type biological program (vitellogenesis).
KW - Journal Article
U2 - 10.1016/j.cub.2018.06.035
DO - 10.1016/j.cub.2018.06.035
M3 - Journal article
C2 - 30100339
VL - 28
SP - 2544-2556.e5
JO - Current Biology
JF - Current Biology
SN - 0960-9822
IS - 16
ER -