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Cell sheets in cell therapies

Research output: Contribution to journalJournal article

  • Giles T.S. Kirby
  • Andrew Michelmore
  • Louise E. Smith
  • Jason D. Whittle
  • Robert D. Short
<mark>Journal publication date</mark>02/2018
Issue number2
Number of pages12
Pages (from-to)169-180
Early online date15/12/17
<mark>Original language</mark>English


This review aims to provide a broad introduction to the use of cell sheets and the role of materials in the delivery of cell sheets to patients within a clinical setting. Traditionally, cells sheets have been, and currently are, fabricated using established and accepted cell culture methods within standard formats (e.g., petri dishes) utilizing biological substrates. Synthetic surfaces provide a far more versatile system for culturing and delivering cell sheets. This has the potential to positively affect quality, and efficient, localized cell delivery has a significant impact on patient outcome and on the overall cost of goods. We highlight current applications of these advanced carriers and future applications of these surfaces and cell sheets with an emphasis both on clinical use and regulatory requirements.

Bibliographic note

This is the author’s version of a work that was accepted for publication in Cytotherapy. Changes resulting from the publishing process, such as peer review, editing, corrections, structural formatting, and other quality control mechanisms may not be reflected in this document. Changes may have been made to this work since it was submitted for publication. A definitive version was subsequently published in Cytotherapy, 20, 2, 2018 DOI: 10.1016/j.jcyt.2017.11.004