Final published version
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Research output: Contribution to Journal/Magazine › Review article › peer-review
Research output: Contribution to Journal/Magazine › Review article › peer-review
}
TY - JOUR
T1 - Cerebellar Transcranial Direct Current Stimulation (ctDCS)
T2 - A Novel Approach to Understanding Cerebellar Function in Health and Disease
AU - Grimaldi, Giuliana
AU - Argyropoulos, Georgios P
AU - Bastian, Amy
AU - Cortes, Mar
AU - Davis, Nicholas J
AU - Edwards, Dylan J
AU - Ferrucci, Roberta
AU - Fregni, Felipe
AU - Galea, Joseph M
AU - Hamada, Masahi
AU - Manto, Mario
AU - Miall, R Chris
AU - Morales-Quezada, Leon
AU - Pope, Paul A
AU - Priori, Alberto
AU - Rothwell, John
AU - Tomlinson, S Paul
AU - Celnik, Pablo
N1 - © The Author(s) 2014.
PY - 2016/2
Y1 - 2016/2
N2 - The cerebellum is critical for both motor and cognitive control. Dysfunction of the cerebellum is a component of multiple neurological disorders. In recent years, interventions have been developed that aim to excite or inhibit the activity and function of the human cerebellum. Transcranial direct current stimulation of the cerebellum (ctDCS) promises to be a powerful tool for the modulation of cerebellar excitability. This technique has gained popularity in recent years as it can be used to investigate human cerebellar function, is easily delivered, is well tolerated, and has not shown serious adverse effects. Importantly, the ability of ctDCS to modify behavior makes it an interesting approach with a potential therapeutic role for neurological patients. Through both electrical and non-electrical effects (vascular, metabolic) ctDCS is thought to modify the activity of the cerebellum and alter the output from cerebellar nuclei. Physiological studies have shown a polarity-specific effect on the modulation of cerebellar-motor cortex connectivity, likely via cerebellar-thalamocortical pathways. Modeling studies that have assessed commonly used electrode montages have shown that the ctDCS-generated electric field reaches the human cerebellum with little diffusion to neighboring structures. The posterior and inferior parts of the cerebellum (i.e., lobules VI-VIII) seem particularly susceptible to modulation by ctDCS. Numerous studies have shown to date that ctDCS can modulate motor learning, and affect cognitive and emotional processes. Importantly, this intervention has a good safety profile; similar to when applied over cerebral areas. Thus, investigations have begun exploring ctDCS as a viable intervention for patients with neurological conditions.
AB - The cerebellum is critical for both motor and cognitive control. Dysfunction of the cerebellum is a component of multiple neurological disorders. In recent years, interventions have been developed that aim to excite or inhibit the activity and function of the human cerebellum. Transcranial direct current stimulation of the cerebellum (ctDCS) promises to be a powerful tool for the modulation of cerebellar excitability. This technique has gained popularity in recent years as it can be used to investigate human cerebellar function, is easily delivered, is well tolerated, and has not shown serious adverse effects. Importantly, the ability of ctDCS to modify behavior makes it an interesting approach with a potential therapeutic role for neurological patients. Through both electrical and non-electrical effects (vascular, metabolic) ctDCS is thought to modify the activity of the cerebellum and alter the output from cerebellar nuclei. Physiological studies have shown a polarity-specific effect on the modulation of cerebellar-motor cortex connectivity, likely via cerebellar-thalamocortical pathways. Modeling studies that have assessed commonly used electrode montages have shown that the ctDCS-generated electric field reaches the human cerebellum with little diffusion to neighboring structures. The posterior and inferior parts of the cerebellum (i.e., lobules VI-VIII) seem particularly susceptible to modulation by ctDCS. Numerous studies have shown to date that ctDCS can modulate motor learning, and affect cognitive and emotional processes. Importantly, this intervention has a good safety profile; similar to when applied over cerebral areas. Thus, investigations have begun exploring ctDCS as a viable intervention for patients with neurological conditions.
KW - Animals
KW - Cerebellar Ataxia
KW - Cerebellum
KW - Humans
KW - Motor Cortex
KW - Neuronal Plasticity
KW - Transcranial Direct Current Stimulation
KW - Journal Article
KW - Research Support, N.I.H., Extramural
KW - Research Support, Non-U.S. Gov't
KW - Review
U2 - 10.1177/1073858414559409
DO - 10.1177/1073858414559409
M3 - Review article
C2 - 25406224
VL - 22
SP - 83
EP - 97
JO - The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
JF - The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
SN - 1073-8584
IS - 1
ER -