Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Cerebral amyloid angiopathy as a cause of subarachnoid hemorrhage
AU - Ohshima, T
AU - Endo, T
AU - Nukui, H
AU - Ikeda, S
AU - Allsop, D
AU - Onaya, T
PY - 1990/3
Y1 - 1990/3
N2 - Cerebral amyloid angiopathy is a pathologic condition characterized by the deposition of amyloid in the walls of small vessels in the cerebral cortex and meninges. Intracerebral hemorrhage is common in persons with this condition, but pure subarachnoid or subdural hemorrhage is rarely seen. Recently, the existence of two types of amyloid proteins related to cerebral amyloid angiopathy, beta protein and cystatin C, has been reported, and immunohistochemical methods using antisera to these proteins have become available. We describe a patient with fatal subarachnoid hemorrhage presumably caused by beta protein-type cerebral amyloid angiopathy, which was demonstrated immunohistochemically by using a monoclonal antibody to a synthetic peptide corresponding to residues 8-17 of beta protein. We suggest that beta protein-type cerebral amyloid angiopathy is a possible etiologic factor in subarachnoid hemorrhage of unknown cause.
AB - Cerebral amyloid angiopathy is a pathologic condition characterized by the deposition of amyloid in the walls of small vessels in the cerebral cortex and meninges. Intracerebral hemorrhage is common in persons with this condition, but pure subarachnoid or subdural hemorrhage is rarely seen. Recently, the existence of two types of amyloid proteins related to cerebral amyloid angiopathy, beta protein and cystatin C, has been reported, and immunohistochemical methods using antisera to these proteins have become available. We describe a patient with fatal subarachnoid hemorrhage presumably caused by beta protein-type cerebral amyloid angiopathy, which was demonstrated immunohistochemically by using a monoclonal antibody to a synthetic peptide corresponding to residues 8-17 of beta protein. We suggest that beta protein-type cerebral amyloid angiopathy is a possible etiologic factor in subarachnoid hemorrhage of unknown cause.
KW - Aged
KW - Amyloidosis
KW - Brain
KW - Cerebrovascular Disorders
KW - Congo Red
KW - Humans
KW - Immunohistochemistry
KW - Male
KW - Subarachnoid Hemorrhage
KW - Tomography, X-Ray Computed
U2 - 10.1161/01.STR.21.3.480
DO - 10.1161/01.STR.21.3.480
M3 - Journal article
C2 - 2309274
VL - 21
SP - 480
EP - 483
JO - Stroke; a journal of cerebral circulation
JF - Stroke; a journal of cerebral circulation
SN - 0039-2499
IS - 3
ER -