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cGAS-independent STING activation in response to DNA damage

Research output: Contribution to journalJournal article

Published
Article numbere1558682
<mark>Journal publication date</mark>19/04/2019
<mark>Journal</mark>Molecular & Cellular Oncology
Issue number4
Volume6
Number of pages3
Publication statusPublished
Original languageEnglish

Abstract

Self-DNA has previously been thought to be protected from immune detection by compartmentalisation in the nucleus or mitochondria. Here, we describe the discovery of a signalling cascade that links the detection of DNA damage in the nucleus to the activation of the innate immune adaptor STING (STimulator of INterfern Genes).