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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - cGAS-independent STING activation in response to DNA damage
AU - Unterholzner, Leonie
AU - Dunphy, Gillian
PY - 2019/4/19
Y1 - 2019/4/19
N2 - Self-DNA has previously been thought to be protected from immune detection by compartmentalisation in the nucleus or mitochondria. Here, we describe the discovery of a signalling cascade that links the detection of DNA damage in the nucleus to the activation of the innate immune adaptor STING (STimulator of INterfern Genes).
AB - Self-DNA has previously been thought to be protected from immune detection by compartmentalisation in the nucleus or mitochondria. Here, we describe the discovery of a signalling cascade that links the detection of DNA damage in the nucleus to the activation of the innate immune adaptor STING (STimulator of INterfern Genes).
U2 - 10.1080/23723556.2018.1558682
DO - 10.1080/23723556.2018.1558682
M3 - Journal article
VL - 6
JO - Molecular & Cellular Oncology
JF - Molecular & Cellular Oncology
SN - 2372-3556
IS - 4
M1 - e1558682
ER -