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  • AIP2009ChargeFluctuations

    Rights statement: Copyright 2009 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in AIP Conference Proceedings, 1129 (535), 2009 and may be found at http://link.aip.org/link/?APCPCS/1129/535/1

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Charge fluctuations and boundary conditions of biological ion channels: effect on the ionic transition rate

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Charge fluctuations and boundary conditions of biological ion channels: effect on the ionic transition rate. / Tindjong, R.; Luchinsky, D. G.; McClintock, P. V. E. et al.
In: AIP Conference Proceedings, Vol. 1129, 2009, p. 535-538.

Research output: Contribution to Journal/MagazineJournal article

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Tindjong R, Luchinsky DG, McClintock PVE, Eisenberg RS. Charge fluctuations and boundary conditions of biological ion channels: effect on the ionic transition rate. AIP Conference Proceedings. 2009;1129:535-538. doi: 10.1063/1.3140528

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Bibtex

@article{4c0f02d8365b4e0396229d915303f1ed,
title = "Charge fluctuations and boundary conditions of biological ion channels: effect on the ionic transition rate",
abstract = "A self-consistent solution is derived for the Poisson-Nernst-Planck (PNP) equation, valid both inside a biological ion channel and in the adjacent bulk fluid. An iterative procedure is used to match the two solutions together at the channel mouth. Charge fluctuations at the mouth are modeled as shot noise flipping the height of the potential barrier at the selectivity site. The resultant estimates of the conductivity of the ion channel are in good agreement with Gramicidin experimental measurements and they reproduce the observed current saturation with increasing concentration.",
author = "R. Tindjong and Luchinsky, {D. G.} and McClintock, {P. V. E.} and Eisenberg, {R. S.}",
note = "Copyright 2009 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in AIP Conference Proceedings, 1129 (535), 2009 and may be found at http://link.aip.org/link/?APCPCS/1129/535/1",
year = "2009",
doi = "10.1063/1.3140528",
language = "English",
volume = "1129",
pages = "535--538",
journal = "AIP Conference Proceedings",
issn = "0094-243X",
publisher = "American Institute of Physics Publising LLC",

}

RIS

TY - JOUR

T1 - Charge fluctuations and boundary conditions of biological ion channels

T2 - effect on the ionic transition rate

AU - Tindjong, R.

AU - Luchinsky, D. G.

AU - McClintock, P. V. E.

AU - Eisenberg, R. S.

N1 - Copyright 2009 American Institute of Physics. This article may be downloaded for personal use only. Any other use requires prior permission of the author and the American Institute of Physics. The following article appeared in AIP Conference Proceedings, 1129 (535), 2009 and may be found at http://link.aip.org/link/?APCPCS/1129/535/1

PY - 2009

Y1 - 2009

N2 - A self-consistent solution is derived for the Poisson-Nernst-Planck (PNP) equation, valid both inside a biological ion channel and in the adjacent bulk fluid. An iterative procedure is used to match the two solutions together at the channel mouth. Charge fluctuations at the mouth are modeled as shot noise flipping the height of the potential barrier at the selectivity site. The resultant estimates of the conductivity of the ion channel are in good agreement with Gramicidin experimental measurements and they reproduce the observed current saturation with increasing concentration.

AB - A self-consistent solution is derived for the Poisson-Nernst-Planck (PNP) equation, valid both inside a biological ion channel and in the adjacent bulk fluid. An iterative procedure is used to match the two solutions together at the channel mouth. Charge fluctuations at the mouth are modeled as shot noise flipping the height of the potential barrier at the selectivity site. The resultant estimates of the conductivity of the ion channel are in good agreement with Gramicidin experimental measurements and they reproduce the observed current saturation with increasing concentration.

U2 - 10.1063/1.3140528

DO - 10.1063/1.3140528

M3 - Journal article

VL - 1129

SP - 535

EP - 538

JO - AIP Conference Proceedings

JF - AIP Conference Proceedings

SN - 0094-243X

ER -