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Charge fluctuations and boundary conditions of biological ion channels: effect on the ionic transition rate.

Research output: Contribution in Book/Report/ProceedingsChapter

Published

Publication date2009
Host publicationNoise and Fluctuations : 20th International Conference on Noise and Fluctuations (ICNF-2009)
EditorsM. Macucci, G. Basso
Place of publicationMelville, N. Y.
PublisherAmerican Institute of Physics
Pages535-538
Number of pages4
Volume1129
Original languageEnglish

Publication series

NameAIP Conference Proceedings
PublisherAmerican Institute of Physics

Abstract

A self-consistent solution is derived for the Poisson-Nernst-Planck (PNP) equation, valid both inside a biological ion channel and in the adjacent bulk fluid. An iterative procedure is used to match the two solutions together at the channel mouth. Charge fluctuations at the mouth are modeled as shot noise flipping the height of the potential barrier at the selectivity site. The resultant estimates of the conductivity of the ion channel are in good agreement with Gramicidin experimental measurements and they reproduce the observed current saturation with increasing concentration.