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Charge fluctuations and their effect on conduction in biological ion channels.

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Charge fluctuations and their effect on conduction in biological ion channels. / Luchinsky, D. G.; Tindjong, R.; Kaufman, I. et al.
In: Journal of Statistical Mechanics: Theory and Experiment, Vol. 2009, P01010, 2009.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Luchinsky, DG, Tindjong, R, Kaufman, I, McClintock, PVE & Eisenberg, RS 2009, 'Charge fluctuations and their effect on conduction in biological ion channels.', Journal of Statistical Mechanics: Theory and Experiment, vol. 2009, P01010. https://doi.org/10.1088/1742-5468/2009/01/P01010

APA

Luchinsky, D. G., Tindjong, R., Kaufman, I., McClintock, P. V. E., & Eisenberg, R. S. (2009). Charge fluctuations and their effect on conduction in biological ion channels. Journal of Statistical Mechanics: Theory and Experiment, 2009, Article P01010. https://doi.org/10.1088/1742-5468/2009/01/P01010

Vancouver

Luchinsky DG, Tindjong R, Kaufman I, McClintock PVE, Eisenberg RS. Charge fluctuations and their effect on conduction in biological ion channels. Journal of Statistical Mechanics: Theory and Experiment. 2009;2009:P01010. doi: 10.1088/1742-5468/2009/01/P01010

Author

Luchinsky, D. G. ; Tindjong, R. ; Kaufman, I. et al. / Charge fluctuations and their effect on conduction in biological ion channels. In: Journal of Statistical Mechanics: Theory and Experiment. 2009 ; Vol. 2009.

Bibtex

@article{bb9efe6e47e24b4f83445c1b5d26ef5e,
title = "Charge fluctuations and their effect on conduction in biological ion channels.",
abstract = "The effect of fluctuations on the conductivity of ion channels is investigated. It is shown that modulation of the potential barrier at the selectivity site due to electrostatic amplification of charge fluctuations at the channel mouth exerts a leading-order effect on the channel conductivity. A Brownian dynamical model of ion motion in a channel is derived that takes into account both fluctuations at the channel mouth and vibrational modes of the wall. The charge fluctuations are modeled as a shot noise flipping the height of the potential barrier. The wall fluctuations are introduced as a slow vibrational mode of the protein motion that modulates ion conductance both stochastically and periodically. The model is used to estimate the contribution to the conductivity of ion channels coming from the electrostatic amplification of charge fluctuations.",
keywords = "dynamics (theory), diffusion",
author = "Luchinsky, {D. G.} and R. Tindjong and I. Kaufman and McClintock, {P. V. E.} and R.S. Eisenberg",
year = "2009",
doi = "10.1088/1742-5468/2009/01/P01010",
language = "English",
volume = "2009",
journal = "Journal of Statistical Mechanics: Theory and Experiment",
publisher = "IOP Publishing Ltd.",

}

RIS

TY - JOUR

T1 - Charge fluctuations and their effect on conduction in biological ion channels.

AU - Luchinsky, D. G.

AU - Tindjong, R.

AU - Kaufman, I.

AU - McClintock, P. V. E.

AU - Eisenberg, R.S.

PY - 2009

Y1 - 2009

N2 - The effect of fluctuations on the conductivity of ion channels is investigated. It is shown that modulation of the potential barrier at the selectivity site due to electrostatic amplification of charge fluctuations at the channel mouth exerts a leading-order effect on the channel conductivity. A Brownian dynamical model of ion motion in a channel is derived that takes into account both fluctuations at the channel mouth and vibrational modes of the wall. The charge fluctuations are modeled as a shot noise flipping the height of the potential barrier. The wall fluctuations are introduced as a slow vibrational mode of the protein motion that modulates ion conductance both stochastically and periodically. The model is used to estimate the contribution to the conductivity of ion channels coming from the electrostatic amplification of charge fluctuations.

AB - The effect of fluctuations on the conductivity of ion channels is investigated. It is shown that modulation of the potential barrier at the selectivity site due to electrostatic amplification of charge fluctuations at the channel mouth exerts a leading-order effect on the channel conductivity. A Brownian dynamical model of ion motion in a channel is derived that takes into account both fluctuations at the channel mouth and vibrational modes of the wall. The charge fluctuations are modeled as a shot noise flipping the height of the potential barrier. The wall fluctuations are introduced as a slow vibrational mode of the protein motion that modulates ion conductance both stochastically and periodically. The model is used to estimate the contribution to the conductivity of ion channels coming from the electrostatic amplification of charge fluctuations.

KW - dynamics (theory)

KW - diffusion

U2 - 10.1088/1742-5468/2009/01/P01010

DO - 10.1088/1742-5468/2009/01/P01010

M3 - Journal article

VL - 2009

JO - Journal of Statistical Mechanics: Theory and Experiment

JF - Journal of Statistical Mechanics: Theory and Experiment

M1 - P01010

ER -