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Chemical synthesis and cytotoxicity of dihydroxylated cyclopentenone analogues of neocarzinostatin chromophore

Research output: Contribution to journalJournal article

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  • Michael D. Urbaniak
  • Lisa M. Frost
  • John P. Bingham
  • Lloyd R. Kelland
  • John A. Hartley
  • Derek N. Woolfson
  • Stephen Caddick
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<mark>Journal publication date</mark>16/06/2003
<mark>Journal</mark>Bioorganic and Medicinal Chemistry Letters
Issue number12
Volume13
Number of pages3
Pages (from-to)2025-2027
<mark>State</mark>Published
<mark>Original language</mark>English

Abstract

Compounds containing the naphthoate moiety of Neocarzinostatin chromophore or 2-hydroxynaphthoate have been synthesized and evaluated for cytotoxic activity against a leukemia cell line and a small panel of human-tumor cell lines. Those compounds containing a cyclopentenone moiety were active, with the carbonyl group being essential for biological activity.