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Chemical synthesis and cytotoxicity of dihydroxylated cyclopentenone analogues of neocarzinostatin chromophore

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Chemical synthesis and cytotoxicity of dihydroxylated cyclopentenone analogues of neocarzinostatin chromophore. / Urbaniak, Michael D.; Frost, Lisa M.; Bingham, John P. et al.
In: Bioorganic and Medicinal Chemistry Letters, Vol. 13, No. 12, 16.06.2003, p. 2025-2027.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Urbaniak, MD, Frost, LM, Bingham, JP, Kelland, LR, Hartley, JA, Woolfson, DN & Caddick, S 2003, 'Chemical synthesis and cytotoxicity of dihydroxylated cyclopentenone analogues of neocarzinostatin chromophore', Bioorganic and Medicinal Chemistry Letters, vol. 13, no. 12, pp. 2025-2027. https://doi.org/10.1016/S0960-894X(03)00328-7

APA

Urbaniak, M. D., Frost, L. M., Bingham, J. P., Kelland, L. R., Hartley, J. A., Woolfson, D. N., & Caddick, S. (2003). Chemical synthesis and cytotoxicity of dihydroxylated cyclopentenone analogues of neocarzinostatin chromophore. Bioorganic and Medicinal Chemistry Letters, 13(12), 2025-2027. https://doi.org/10.1016/S0960-894X(03)00328-7

Vancouver

Urbaniak MD, Frost LM, Bingham JP, Kelland LR, Hartley JA, Woolfson DN et al. Chemical synthesis and cytotoxicity of dihydroxylated cyclopentenone analogues of neocarzinostatin chromophore. Bioorganic and Medicinal Chemistry Letters. 2003 Jun 16;13(12):2025-2027. doi: 10.1016/S0960-894X(03)00328-7

Author

Urbaniak, Michael D. ; Frost, Lisa M. ; Bingham, John P. et al. / Chemical synthesis and cytotoxicity of dihydroxylated cyclopentenone analogues of neocarzinostatin chromophore. In: Bioorganic and Medicinal Chemistry Letters. 2003 ; Vol. 13, No. 12. pp. 2025-2027.

Bibtex

@article{9787124282ef4614b4f3d7b6ad4c4ab2,
title = "Chemical synthesis and cytotoxicity of dihydroxylated cyclopentenone analogues of neocarzinostatin chromophore",
abstract = "Compounds containing the naphthoate moiety of Neocarzinostatin chromophore or 2-hydroxynaphthoate have been synthesized and evaluated for cytotoxic activity against a leukemia cell line and a small panel of human-tumor cell lines. Those compounds containing a cyclopentenone moiety were active, with the carbonyl group being essential for biological activity.",
keywords = "Antibiotics, Antineoplastic, Cell Line, Tumor, Cyclopentanes, Drug Screening Assays, Antitumor, Enediynes, HT29 Cells, Humans, Hydroxylation, Inhibitory Concentration 50, K562 Cells, Zinostatin",
author = "Urbaniak, {Michael D.} and Frost, {Lisa M.} and Bingham, {John P.} and Kelland, {Lloyd R.} and Hartley, {John A.} and Woolfson, {Derek N.} and Stephen Caddick",
year = "2003",
month = jun,
day = "16",
doi = "10.1016/S0960-894X(03)00328-7",
language = "English",
volume = "13",
pages = "2025--2027",
journal = "Bioorganic and Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Elsevier Limited",
number = "12",

}

RIS

TY - JOUR

T1 - Chemical synthesis and cytotoxicity of dihydroxylated cyclopentenone analogues of neocarzinostatin chromophore

AU - Urbaniak, Michael D.

AU - Frost, Lisa M.

AU - Bingham, John P.

AU - Kelland, Lloyd R.

AU - Hartley, John A.

AU - Woolfson, Derek N.

AU - Caddick, Stephen

PY - 2003/6/16

Y1 - 2003/6/16

N2 - Compounds containing the naphthoate moiety of Neocarzinostatin chromophore or 2-hydroxynaphthoate have been synthesized and evaluated for cytotoxic activity against a leukemia cell line and a small panel of human-tumor cell lines. Those compounds containing a cyclopentenone moiety were active, with the carbonyl group being essential for biological activity.

AB - Compounds containing the naphthoate moiety of Neocarzinostatin chromophore or 2-hydroxynaphthoate have been synthesized and evaluated for cytotoxic activity against a leukemia cell line and a small panel of human-tumor cell lines. Those compounds containing a cyclopentenone moiety were active, with the carbonyl group being essential for biological activity.

KW - Antibiotics, Antineoplastic

KW - Cell Line, Tumor

KW - Cyclopentanes

KW - Drug Screening Assays, Antitumor

KW - Enediynes

KW - HT29 Cells

KW - Humans

KW - Hydroxylation

KW - Inhibitory Concentration 50

KW - K562 Cells

KW - Zinostatin

U2 - 10.1016/S0960-894X(03)00328-7

DO - 10.1016/S0960-894X(03)00328-7

M3 - Journal article

C2 - 12781188

VL - 13

SP - 2025

EP - 2027

JO - Bioorganic and Medicinal Chemistry Letters

JF - Bioorganic and Medicinal Chemistry Letters

SN - 0960-894X

IS - 12

ER -