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Chemically induced phospholipid translocation across biological membranes

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Chemically induced phospholipid translocation across biological membranes. / Gurtovenko, Andrey A.; Onike, Olajide I.; Anwar, Jamshed.
In: Langmuir, Vol. 24, No. 17, 02.09.2008, p. 9656-9660.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Gurtovenko, AA, Onike, OI & Anwar, J 2008, 'Chemically induced phospholipid translocation across biological membranes', Langmuir, vol. 24, no. 17, pp. 9656-9660. https://doi.org/10.1021/la801431f

APA

Gurtovenko, A. A., Onike, O. I., & Anwar, J. (2008). Chemically induced phospholipid translocation across biological membranes. Langmuir, 24(17), 9656-9660. https://doi.org/10.1021/la801431f

Vancouver

Gurtovenko AA, Onike OI, Anwar J. Chemically induced phospholipid translocation across biological membranes. Langmuir. 2008 Sept 2;24(17):9656-9660. doi: 10.1021/la801431f

Author

Gurtovenko, Andrey A. ; Onike, Olajide I. ; Anwar, Jamshed. / Chemically induced phospholipid translocation across biological membranes. In: Langmuir. 2008 ; Vol. 24, No. 17. pp. 9656-9660.

Bibtex

@article{b1412fc8c6d946e3826d794895bcebb6,
title = "Chemically induced phospholipid translocation across biological membranes",
abstract = "Chemical means of manipulating the distribution of lipids across biological membranes is of considerable interest for many biomedical applications as a characteristic lipid distribution is vital for numerous cellular functions. Here we employ atomic-scale molecular simulations to shed light on the ability of certain amphiphilic compounds to promote lipid translocation (flip-flops) across membranes. We show that chemically induced lipid flip-flops are most likely pore-mediated: the actual flip-flop event is a very fast process (time scales of tens of nanoseconds) once a transient water defect has been induced by the amphiphilic chemical (dimethylsulfoxide in this instance). Our findings are consistent with available experimental observations and further emphasize the importance of transient membrane defects for chemical control of lipid distribution across cell membranes.",
keywords = "LIPID-MEMBRANES, PARTICLE MESH EWALD, ASYMMETRY, TRANSVERSE MOBILITY, MOLECULAR-DYNAMICS SIMULATIONS, DIMETHYL-SULFOXIDE, HUMAN-ERYTHROCYTE-MEMBRANE, DIMETHYLSULFOXIDE, BILAYER, LOCAL-ANESTHETICS",
author = "Gurtovenko, {Andrey A.} and Onike, {Olajide I.} and Jamshed Anwar",
year = "2008",
month = sep,
day = "2",
doi = "10.1021/la801431f",
language = "English",
volume = "24",
pages = "9656--9660",
journal = "Langmuir",
issn = "0743-7463",
publisher = "AMER CHEMICAL SOC",
number = "17",

}

RIS

TY - JOUR

T1 - Chemically induced phospholipid translocation across biological membranes

AU - Gurtovenko, Andrey A.

AU - Onike, Olajide I.

AU - Anwar, Jamshed

PY - 2008/9/2

Y1 - 2008/9/2

N2 - Chemical means of manipulating the distribution of lipids across biological membranes is of considerable interest for many biomedical applications as a characteristic lipid distribution is vital for numerous cellular functions. Here we employ atomic-scale molecular simulations to shed light on the ability of certain amphiphilic compounds to promote lipid translocation (flip-flops) across membranes. We show that chemically induced lipid flip-flops are most likely pore-mediated: the actual flip-flop event is a very fast process (time scales of tens of nanoseconds) once a transient water defect has been induced by the amphiphilic chemical (dimethylsulfoxide in this instance). Our findings are consistent with available experimental observations and further emphasize the importance of transient membrane defects for chemical control of lipid distribution across cell membranes.

AB - Chemical means of manipulating the distribution of lipids across biological membranes is of considerable interest for many biomedical applications as a characteristic lipid distribution is vital for numerous cellular functions. Here we employ atomic-scale molecular simulations to shed light on the ability of certain amphiphilic compounds to promote lipid translocation (flip-flops) across membranes. We show that chemically induced lipid flip-flops are most likely pore-mediated: the actual flip-flop event is a very fast process (time scales of tens of nanoseconds) once a transient water defect has been induced by the amphiphilic chemical (dimethylsulfoxide in this instance). Our findings are consistent with available experimental observations and further emphasize the importance of transient membrane defects for chemical control of lipid distribution across cell membranes.

KW - LIPID-MEMBRANES

KW - PARTICLE MESH EWALD

KW - ASYMMETRY

KW - TRANSVERSE MOBILITY

KW - MOLECULAR-DYNAMICS SIMULATIONS

KW - DIMETHYL-SULFOXIDE

KW - HUMAN-ERYTHROCYTE-MEMBRANE

KW - DIMETHYLSULFOXIDE

KW - BILAYER

KW - LOCAL-ANESTHETICS

U2 - 10.1021/la801431f

DO - 10.1021/la801431f

M3 - Journal article

VL - 24

SP - 9656

EP - 9660

JO - Langmuir

JF - Langmuir

SN - 0743-7463

IS - 17

ER -