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Childhood adversities increase the risk of psychosis: a meta-analysis of patient- control, prospective- and cross-sectional cohort studies

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Childhood adversities increase the risk of psychosis : a meta-analysis of patient- control, prospective- and cross-sectional cohort studies. / Varese, Filippo; Smeets, Feikje; Drukker, Marjan; Lieverse, Ritsaert; Lataster, Tineke; Viechbauer, Wolfgang; Read, John; van Os, Jim; Bentall, Richard P.

In: Schizophrenia Bulletin, Vol. 38, No. 4, 07.2012, p. 661-671.

Research output: Contribution to journalJournal article

Harvard

Varese, F, Smeets, F, Drukker, M, Lieverse, R, Lataster, T, Viechbauer, W, Read, J, van Os, J & Bentall, RP 2012, 'Childhood adversities increase the risk of psychosis: a meta-analysis of patient- control, prospective- and cross-sectional cohort studies', Schizophrenia Bulletin, vol. 38, no. 4, pp. 661-671. https://doi.org/10.1093/schbul/sbs050

APA

Varese, F., Smeets, F., Drukker, M., Lieverse, R., Lataster, T., Viechbauer, W., Read, J., van Os, J., & Bentall, R. P. (2012). Childhood adversities increase the risk of psychosis: a meta-analysis of patient- control, prospective- and cross-sectional cohort studies. Schizophrenia Bulletin, 38(4), 661-671. https://doi.org/10.1093/schbul/sbs050

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Author

Varese, Filippo ; Smeets, Feikje ; Drukker, Marjan ; Lieverse, Ritsaert ; Lataster, Tineke ; Viechbauer, Wolfgang ; Read, John ; van Os, Jim ; Bentall, Richard P. / Childhood adversities increase the risk of psychosis : a meta-analysis of patient- control, prospective- and cross-sectional cohort studies. In: Schizophrenia Bulletin. 2012 ; Vol. 38, No. 4. pp. 661-671.

Bibtex

@article{ae45498f30264b248143bc2e7d755aca,
title = "Childhood adversities increase the risk of psychosis: a meta-analysis of patient- control, prospective- and cross-sectional cohort studies",
abstract = "Evidence suggests that adverse experiences in childhood are associated with psychosis. To examine the association between childhood adversity and trauma (sexual abuse, physical abuse, emotional/psychological abuse, neglect, parental death, and bullying) and psychosis outcome, MEDLINE, EMBASE, PsychINFO, and Web of Science were searched from January 1980 through November 2011. We included prospective cohort studies, large-scale cross-sectional studies investigating the association between childhood adversity and psychotic symptoms or illness, case-control studies comparing the prevalence of adverse events between psychotic patients and controls using dichotomous or continuous measures, and case-control studies comparing the prevalence of psychotic symptoms between exposed and nonexposed subjects using dichotomous or continuous measures of adversity and psychosis. The analysis included 18 case-control studies (n = 2048 psychotic patients and 1856 nonpsychiatric controls), 10 prospective and quasi-prospective studies (n = 41 803) and 8 population-based cross-sectional studies (n = 35 546). There were significant associations between adversity and psychosis across all research designs, with an overall effect of OR = 2.78 (95% CI = 2.34–3.31). The integration of the case-control studies indicated that patients with psychosis were 2.72 times more likely to have been exposed to childhood adversity than controls (95% CI = 1.90–3.88). The association between childhood adversity and psychosis was also significant in population-based cross-sectional studies (OR = 2.99 [95% CI = 2.12–4.20]) as well as in prospective and quasi-prospective studies (OR = 2.75 [95% CI = 2.17–3.47]). The estimated population attributable risk was 33% (16%–47%). These findings indicate that childhood adversity is strongly associated with increased risk for psychosis.",
keywords = "psychosis, Meta-analysis, adversity, trauma, abuse, neglect",
author = "Filippo Varese and Feikje Smeets and Marjan Drukker and Ritsaert Lieverse and Tineke Lataster and Wolfgang Viechbauer and John Read and {van Os}, Jim and Bentall, {Richard P.}",
year = "2012",
month = jul,
doi = "10.1093/schbul/sbs050",
language = "English",
volume = "38",
pages = "661--671",
journal = "Schizophrenia Bulletin",
issn = "0586-7614",
publisher = "Oxford University Press",
number = "4",

}

RIS

TY - JOUR

T1 - Childhood adversities increase the risk of psychosis

T2 - a meta-analysis of patient- control, prospective- and cross-sectional cohort studies

AU - Varese, Filippo

AU - Smeets, Feikje

AU - Drukker, Marjan

AU - Lieverse, Ritsaert

AU - Lataster, Tineke

AU - Viechbauer, Wolfgang

AU - Read, John

AU - van Os, Jim

AU - Bentall, Richard P.

PY - 2012/7

Y1 - 2012/7

N2 - Evidence suggests that adverse experiences in childhood are associated with psychosis. To examine the association between childhood adversity and trauma (sexual abuse, physical abuse, emotional/psychological abuse, neglect, parental death, and bullying) and psychosis outcome, MEDLINE, EMBASE, PsychINFO, and Web of Science were searched from January 1980 through November 2011. We included prospective cohort studies, large-scale cross-sectional studies investigating the association between childhood adversity and psychotic symptoms or illness, case-control studies comparing the prevalence of adverse events between psychotic patients and controls using dichotomous or continuous measures, and case-control studies comparing the prevalence of psychotic symptoms between exposed and nonexposed subjects using dichotomous or continuous measures of adversity and psychosis. The analysis included 18 case-control studies (n = 2048 psychotic patients and 1856 nonpsychiatric controls), 10 prospective and quasi-prospective studies (n = 41 803) and 8 population-based cross-sectional studies (n = 35 546). There were significant associations between adversity and psychosis across all research designs, with an overall effect of OR = 2.78 (95% CI = 2.34–3.31). The integration of the case-control studies indicated that patients with psychosis were 2.72 times more likely to have been exposed to childhood adversity than controls (95% CI = 1.90–3.88). The association between childhood adversity and psychosis was also significant in population-based cross-sectional studies (OR = 2.99 [95% CI = 2.12–4.20]) as well as in prospective and quasi-prospective studies (OR = 2.75 [95% CI = 2.17–3.47]). The estimated population attributable risk was 33% (16%–47%). These findings indicate that childhood adversity is strongly associated with increased risk for psychosis.

AB - Evidence suggests that adverse experiences in childhood are associated with psychosis. To examine the association between childhood adversity and trauma (sexual abuse, physical abuse, emotional/psychological abuse, neglect, parental death, and bullying) and psychosis outcome, MEDLINE, EMBASE, PsychINFO, and Web of Science were searched from January 1980 through November 2011. We included prospective cohort studies, large-scale cross-sectional studies investigating the association between childhood adversity and psychotic symptoms or illness, case-control studies comparing the prevalence of adverse events between psychotic patients and controls using dichotomous or continuous measures, and case-control studies comparing the prevalence of psychotic symptoms between exposed and nonexposed subjects using dichotomous or continuous measures of adversity and psychosis. The analysis included 18 case-control studies (n = 2048 psychotic patients and 1856 nonpsychiatric controls), 10 prospective and quasi-prospective studies (n = 41 803) and 8 population-based cross-sectional studies (n = 35 546). There were significant associations between adversity and psychosis across all research designs, with an overall effect of OR = 2.78 (95% CI = 2.34–3.31). The integration of the case-control studies indicated that patients with psychosis were 2.72 times more likely to have been exposed to childhood adversity than controls (95% CI = 1.90–3.88). The association between childhood adversity and psychosis was also significant in population-based cross-sectional studies (OR = 2.99 [95% CI = 2.12–4.20]) as well as in prospective and quasi-prospective studies (OR = 2.75 [95% CI = 2.17–3.47]). The estimated population attributable risk was 33% (16%–47%). These findings indicate that childhood adversity is strongly associated with increased risk for psychosis.

KW - psychosis

KW - Meta-analysis

KW - adversity

KW - trauma

KW - abuse

KW - neglect

U2 - 10.1093/schbul/sbs050

DO - 10.1093/schbul/sbs050

M3 - Journal article

VL - 38

SP - 661

EP - 671

JO - Schizophrenia Bulletin

JF - Schizophrenia Bulletin

SN - 0586-7614

IS - 4

ER -