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Clinical effectiveness of a web-based peer-supported self-management intervention for relatives of people with psychosis or bipolar (REACT): online, observer-blind, randomised controlled superiority trial

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Clinical effectiveness of a web-based peer-supported self-management intervention for relatives of people with psychosis or bipolar (REACT): online, observer-blind, randomised controlled superiority trial. / Lobban, Fiona; Akers, Nadia; Appelbe, Duncan et al.
In: BMC Psychiatry, Vol. 20, No. 1, 160, 14.04.2020.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Lobban, F, Akers, N, Appelbe, D, Chapman, L, Collinge, L, Dodd, S, Flowers, S, Hollingsworth, B, Johnson, S, Jones, SH, Mateus, C, Mezes, B, Murray, E, Panagaki, K, Rainford, N, Robinson, H, Rosala-Hallas, A, Sellwood, W, Walker, A & Williamson, P 2020, 'Clinical effectiveness of a web-based peer-supported self-management intervention for relatives of people with psychosis or bipolar (REACT): online, observer-blind, randomised controlled superiority trial', BMC Psychiatry, vol. 20, no. 1, 160. https://doi.org/10.1186/s12888-020-02545-9

APA

Lobban, F., Akers, N., Appelbe, D., Chapman, L., Collinge, L., Dodd, S., Flowers, S., Hollingsworth, B., Johnson, S., Jones, S. H., Mateus, C., Mezes, B., Murray, E., Panagaki, K., Rainford, N., Robinson, H., Rosala-Hallas, A., Sellwood, W., Walker, A., & Williamson, P. (2020). Clinical effectiveness of a web-based peer-supported self-management intervention for relatives of people with psychosis or bipolar (REACT): online, observer-blind, randomised controlled superiority trial. BMC Psychiatry, 20(1), Article 160. https://doi.org/10.1186/s12888-020-02545-9

Vancouver

Lobban F, Akers N, Appelbe D, Chapman L, Collinge L, Dodd S et al. Clinical effectiveness of a web-based peer-supported self-management intervention for relatives of people with psychosis or bipolar (REACT): online, observer-blind, randomised controlled superiority trial. BMC Psychiatry. 2020 Apr 14;20(1):160. doi: 10.1186/s12888-020-02545-9

Author

Lobban, Fiona ; Akers, Nadia ; Appelbe, Duncan et al. / Clinical effectiveness of a web-based peer-supported self-management intervention for relatives of people with psychosis or bipolar (REACT) : online, observer-blind, randomised controlled superiority trial. In: BMC Psychiatry. 2020 ; Vol. 20, No. 1.

Bibtex

@article{cbb98980251345e19f6f0a3407fe12dd,
title = "Clinical effectiveness of a web-based peer-supported self-management intervention for relatives of people with psychosis or bipolar (REACT): online, observer-blind, randomised controlled superiority trial",
abstract = "Background The Relatives Education And Coping Toolkit (REACT) is an online supported self-management toolkit for relatives of people with psychosis or bipolar designed to improve access to NICE recommended information and emotional support. Aims Our aim was to determine clinical and cost-effectiveness of REACT including a Resource Directory (RD), versus RD-only. Methods A primarily online, observer-blind randomised controlled trial comparing REACT (including RD) with RD only (registration ). Participants were UK relatives aged > = 16, with high distress (assessed using the GHQ-28), and actively help-seeking, individually randomised, and assessed online. Primary outcome was relatives' distress (GHQ-28) at 24 weeks. Secondary outcomes were wellbeing, support, costs and user feedback. Results We recruited 800 relatives (REACT = 399; RD only = 401) with high distress at baseline (GHQ-28 REACT mean 40.3, SD 14.6; RD only mean 40.0, SD 14.0). Median time spent online on REACT was 50.8 min (IQR 12.4-172.1) versus 0.5 min (IQR 0-1.6) on RD only. Retention to primary follow-up (24 weeks) was 75% (REACT n = 292 (73.2%); RD-only n = 307 (76.6%)). Distress decreased in both groups by 24 weeks, with no significant difference between the two groups (- 1.39, 95% CI -3.60, 0.83, p = 0.22). Estimated cost of delivering REACT was 62.27 pound per person and users reported finding it safe, acceptable and convenient. There were no adverse events or reported side effects. Conclusions REACT is an inexpensive, acceptable, and safe way to deliver NICE-recommended support for relatives. However, for highly distressed relatives it is no more effective in reducing distress (GHQ-28) than a comprehensive online resource directory.",
keywords = "Digital health intervention, Relatives, Psychosis, Bipolar, Randomised controlled trial",
author = "Fiona Lobban and Nadia Akers and Duncan Appelbe and Lesley Chapman and Lizzi Collinge and Susanna Dodd and Sue Flowers and Bruce Hollingsworth and Sonia Johnson and Jones, {Steven H} and Ceu Mateus and Barbara Mezes and Elizabeth Murray and Katerina Panagaki and Naomi Rainford and Heather Robinson and Anna Rosala-Hallas and William Sellwood and Andrew Walker and Paula Williamson",
year = "2020",
month = apr,
day = "14",
doi = "10.1186/s12888-020-02545-9",
language = "English",
volume = "20",
journal = "BMC Psychiatry",
issn = "1471-244X",
publisher = "NLM (Medline)",
number = "1",

}

RIS

TY - JOUR

T1 - Clinical effectiveness of a web-based peer-supported self-management intervention for relatives of people with psychosis or bipolar (REACT)

T2 - online, observer-blind, randomised controlled superiority trial

AU - Lobban, Fiona

AU - Akers, Nadia

AU - Appelbe, Duncan

AU - Chapman, Lesley

AU - Collinge, Lizzi

AU - Dodd, Susanna

AU - Flowers, Sue

AU - Hollingsworth, Bruce

AU - Johnson, Sonia

AU - Jones, Steven H

AU - Mateus, Ceu

AU - Mezes, Barbara

AU - Murray, Elizabeth

AU - Panagaki, Katerina

AU - Rainford, Naomi

AU - Robinson, Heather

AU - Rosala-Hallas, Anna

AU - Sellwood, William

AU - Walker, Andrew

AU - Williamson, Paula

PY - 2020/4/14

Y1 - 2020/4/14

N2 - Background The Relatives Education And Coping Toolkit (REACT) is an online supported self-management toolkit for relatives of people with psychosis or bipolar designed to improve access to NICE recommended information and emotional support. Aims Our aim was to determine clinical and cost-effectiveness of REACT including a Resource Directory (RD), versus RD-only. Methods A primarily online, observer-blind randomised controlled trial comparing REACT (including RD) with RD only (registration ). Participants were UK relatives aged > = 16, with high distress (assessed using the GHQ-28), and actively help-seeking, individually randomised, and assessed online. Primary outcome was relatives' distress (GHQ-28) at 24 weeks. Secondary outcomes were wellbeing, support, costs and user feedback. Results We recruited 800 relatives (REACT = 399; RD only = 401) with high distress at baseline (GHQ-28 REACT mean 40.3, SD 14.6; RD only mean 40.0, SD 14.0). Median time spent online on REACT was 50.8 min (IQR 12.4-172.1) versus 0.5 min (IQR 0-1.6) on RD only. Retention to primary follow-up (24 weeks) was 75% (REACT n = 292 (73.2%); RD-only n = 307 (76.6%)). Distress decreased in both groups by 24 weeks, with no significant difference between the two groups (- 1.39, 95% CI -3.60, 0.83, p = 0.22). Estimated cost of delivering REACT was 62.27 pound per person and users reported finding it safe, acceptable and convenient. There were no adverse events or reported side effects. Conclusions REACT is an inexpensive, acceptable, and safe way to deliver NICE-recommended support for relatives. However, for highly distressed relatives it is no more effective in reducing distress (GHQ-28) than a comprehensive online resource directory.

AB - Background The Relatives Education And Coping Toolkit (REACT) is an online supported self-management toolkit for relatives of people with psychosis or bipolar designed to improve access to NICE recommended information and emotional support. Aims Our aim was to determine clinical and cost-effectiveness of REACT including a Resource Directory (RD), versus RD-only. Methods A primarily online, observer-blind randomised controlled trial comparing REACT (including RD) with RD only (registration ). Participants were UK relatives aged > = 16, with high distress (assessed using the GHQ-28), and actively help-seeking, individually randomised, and assessed online. Primary outcome was relatives' distress (GHQ-28) at 24 weeks. Secondary outcomes were wellbeing, support, costs and user feedback. Results We recruited 800 relatives (REACT = 399; RD only = 401) with high distress at baseline (GHQ-28 REACT mean 40.3, SD 14.6; RD only mean 40.0, SD 14.0). Median time spent online on REACT was 50.8 min (IQR 12.4-172.1) versus 0.5 min (IQR 0-1.6) on RD only. Retention to primary follow-up (24 weeks) was 75% (REACT n = 292 (73.2%); RD-only n = 307 (76.6%)). Distress decreased in both groups by 24 weeks, with no significant difference between the two groups (- 1.39, 95% CI -3.60, 0.83, p = 0.22). Estimated cost of delivering REACT was 62.27 pound per person and users reported finding it safe, acceptable and convenient. There were no adverse events or reported side effects. Conclusions REACT is an inexpensive, acceptable, and safe way to deliver NICE-recommended support for relatives. However, for highly distressed relatives it is no more effective in reducing distress (GHQ-28) than a comprehensive online resource directory.

KW - Digital health intervention

KW - Relatives

KW - Psychosis

KW - Bipolar

KW - Randomised controlled trial

U2 - 10.1186/s12888-020-02545-9

DO - 10.1186/s12888-020-02545-9

M3 - Journal article

C2 - 32290827

VL - 20

JO - BMC Psychiatry

JF - BMC Psychiatry

SN - 1471-244X

IS - 1

M1 - 160

ER -