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Common variation in the WNK1 gene and blood pressure in childhood: the Avon Longitudinal Study of Parents and Children

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Common variation in the WNK1 gene and blood pressure in childhood: the Avon Longitudinal Study of Parents and Children. / Tobin, Martin D.; Timpson, Nicholas J.; Wain, Louise V. et al.
In: Hypertension, Vol. 52, No. 5, 11.2008, p. 974-979.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Tobin, MD, Timpson, NJ, Wain, LV, Ring, S, Jones, LR, Emmett, PM, Palmer, TM, Ness, AR, Samani, NJ, Smith, GD & Burton, PR 2008, 'Common variation in the WNK1 gene and blood pressure in childhood: the Avon Longitudinal Study of Parents and Children', Hypertension, vol. 52, no. 5, pp. 974-979. https://doi.org/10.1161/HYPERTENSIONAHA.108.118414

APA

Tobin, M. D., Timpson, N. J., Wain, L. V., Ring, S., Jones, L. R., Emmett, P. M., Palmer, T. M., Ness, A. R., Samani, N. J., Smith, G. D., & Burton, P. R. (2008). Common variation in the WNK1 gene and blood pressure in childhood: the Avon Longitudinal Study of Parents and Children. Hypertension, 52(5), 974-979. https://doi.org/10.1161/HYPERTENSIONAHA.108.118414

Vancouver

Tobin MD, Timpson NJ, Wain LV, Ring S, Jones LR, Emmett PM et al. Common variation in the WNK1 gene and blood pressure in childhood: the Avon Longitudinal Study of Parents and Children. Hypertension. 2008 Nov;52(5):974-979. doi: 10.1161/HYPERTENSIONAHA.108.118414

Author

Tobin, Martin D. ; Timpson, Nicholas J. ; Wain, Louise V. et al. / Common variation in the WNK1 gene and blood pressure in childhood : the Avon Longitudinal Study of Parents and Children. In: Hypertension. 2008 ; Vol. 52, No. 5. pp. 974-979.

Bibtex

@article{4da25bb5e60d4bbc8a9075357e6bd783,
title = "Common variation in the WNK1 gene and blood pressure in childhood: the Avon Longitudinal Study of Parents and Children",
abstract = "WNK1 gene variants have been associated with adult blood pressure. We aimed to investigate relationships between WNK1 variants and blood pressure, as well as blood pressure change with age, in a longitudinal childhood study. Associations between single nucleotide polymorphisms in WNK1 and blood pressure and the rate of blood pressure change between 7 and 11 years were examined in the Avon Longitudinal Study of Parent and Children Study (n=5326 for systolic blood pressure at 11 years). We observed associations (P<0.05) with diastolic blood pressure gradient with age for 33 of 82 typed and imputed polymorphisms, including polymorphisms in exons 4, 10, and 11 (rs10774466, rs1012729, and rs9804992). The minor allele (G) of rs1012729 (frequency: 25.6%) was associated with a gender-adjusted change in a diastolic blood pressure gradient of -0.11 mm Hg/y (95% CI: -0.20 to -0.03 mm Hg/y; P=0.0054). No associations were shown with the systolic blood pressure gradient. At age 11 years, 30 polymorphisms showed association (P<0.05) with systolic blood pressure, including variants in exons 4 and 10 (rs10774466 and rs1012729). Only 3 polymorphisms were associated with diastolic blood pressure at 11 years. In exploration of polymorphism-dietary cation interactions on systolic blood pressure at 11 years, 59 reached significance (P<0.05; 12.3 expected by chance), mostly (n=33) related to dietary calcium. The findings show that common intronic and exonic WNK1 variants are associated with diastolic blood pressure gradient from 7 to 11 years and with systolic blood pressure at 11 years. Our study suggests that previously reported effects of WNK1 variants on blood pressure are mediated via effects on the gradient of blood pressure change with age.",
keywords = "Aging, Alleles, Blood Pressure, Child, Cohort Studies, Cross-Sectional Studies, England, Exons, Female, Gene Frequency, Genotype, Humans, Intracellular Signaling Peptides and Proteins, Longitudinal Studies, Male, Polymorphism, Single Nucleotide, Prospective Studies, Protein-Serine-Threonine Kinases",
author = "Tobin, {Martin D.} and Timpson, {Nicholas J.} and Wain, {Louise V.} and Susan Ring and Jones, {Louise R.} and Emmett, {Pauline M.} and Palmer, {Thomas M.} and Ness, {Andrew R.} and Samani, {Nilesh J.} and Smith, {George Davey} and Burton, {Paul R.}",
year = "2008",
month = nov,
doi = "10.1161/HYPERTENSIONAHA.108.118414",
language = "English",
volume = "52",
pages = "974--979",
journal = "Hypertension",
issn = "1524-4563",
publisher = "Lippincott Williams and Wilkins",
number = "5",

}

RIS

TY - JOUR

T1 - Common variation in the WNK1 gene and blood pressure in childhood

T2 - the Avon Longitudinal Study of Parents and Children

AU - Tobin, Martin D.

AU - Timpson, Nicholas J.

AU - Wain, Louise V.

AU - Ring, Susan

AU - Jones, Louise R.

AU - Emmett, Pauline M.

AU - Palmer, Thomas M.

AU - Ness, Andrew R.

AU - Samani, Nilesh J.

AU - Smith, George Davey

AU - Burton, Paul R.

PY - 2008/11

Y1 - 2008/11

N2 - WNK1 gene variants have been associated with adult blood pressure. We aimed to investigate relationships between WNK1 variants and blood pressure, as well as blood pressure change with age, in a longitudinal childhood study. Associations between single nucleotide polymorphisms in WNK1 and blood pressure and the rate of blood pressure change between 7 and 11 years were examined in the Avon Longitudinal Study of Parent and Children Study (n=5326 for systolic blood pressure at 11 years). We observed associations (P<0.05) with diastolic blood pressure gradient with age for 33 of 82 typed and imputed polymorphisms, including polymorphisms in exons 4, 10, and 11 (rs10774466, rs1012729, and rs9804992). The minor allele (G) of rs1012729 (frequency: 25.6%) was associated with a gender-adjusted change in a diastolic blood pressure gradient of -0.11 mm Hg/y (95% CI: -0.20 to -0.03 mm Hg/y; P=0.0054). No associations were shown with the systolic blood pressure gradient. At age 11 years, 30 polymorphisms showed association (P<0.05) with systolic blood pressure, including variants in exons 4 and 10 (rs10774466 and rs1012729). Only 3 polymorphisms were associated with diastolic blood pressure at 11 years. In exploration of polymorphism-dietary cation interactions on systolic blood pressure at 11 years, 59 reached significance (P<0.05; 12.3 expected by chance), mostly (n=33) related to dietary calcium. The findings show that common intronic and exonic WNK1 variants are associated with diastolic blood pressure gradient from 7 to 11 years and with systolic blood pressure at 11 years. Our study suggests that previously reported effects of WNK1 variants on blood pressure are mediated via effects on the gradient of blood pressure change with age.

AB - WNK1 gene variants have been associated with adult blood pressure. We aimed to investigate relationships between WNK1 variants and blood pressure, as well as blood pressure change with age, in a longitudinal childhood study. Associations between single nucleotide polymorphisms in WNK1 and blood pressure and the rate of blood pressure change between 7 and 11 years were examined in the Avon Longitudinal Study of Parent and Children Study (n=5326 for systolic blood pressure at 11 years). We observed associations (P<0.05) with diastolic blood pressure gradient with age for 33 of 82 typed and imputed polymorphisms, including polymorphisms in exons 4, 10, and 11 (rs10774466, rs1012729, and rs9804992). The minor allele (G) of rs1012729 (frequency: 25.6%) was associated with a gender-adjusted change in a diastolic blood pressure gradient of -0.11 mm Hg/y (95% CI: -0.20 to -0.03 mm Hg/y; P=0.0054). No associations were shown with the systolic blood pressure gradient. At age 11 years, 30 polymorphisms showed association (P<0.05) with systolic blood pressure, including variants in exons 4 and 10 (rs10774466 and rs1012729). Only 3 polymorphisms were associated with diastolic blood pressure at 11 years. In exploration of polymorphism-dietary cation interactions on systolic blood pressure at 11 years, 59 reached significance (P<0.05; 12.3 expected by chance), mostly (n=33) related to dietary calcium. The findings show that common intronic and exonic WNK1 variants are associated with diastolic blood pressure gradient from 7 to 11 years and with systolic blood pressure at 11 years. Our study suggests that previously reported effects of WNK1 variants on blood pressure are mediated via effects on the gradient of blood pressure change with age.

KW - Aging

KW - Alleles

KW - Blood Pressure

KW - Child

KW - Cohort Studies

KW - Cross-Sectional Studies

KW - England

KW - Exons

KW - Female

KW - Gene Frequency

KW - Genotype

KW - Humans

KW - Intracellular Signaling Peptides and Proteins

KW - Longitudinal Studies

KW - Male

KW - Polymorphism, Single Nucleotide

KW - Prospective Studies

KW - Protein-Serine-Threonine Kinases

U2 - 10.1161/HYPERTENSIONAHA.108.118414

DO - 10.1161/HYPERTENSIONAHA.108.118414

M3 - Journal article

C2 - 18809789

VL - 52

SP - 974

EP - 979

JO - Hypertension

JF - Hypertension

SN - 1524-4563

IS - 5

ER -