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Comparative genetic architectures of schizophrenia in East Asian and European populations

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Comparative genetic architectures of schizophrenia in East Asian and European populations. / Schizophrenia Working Group of the Psychiatric Genomics Consortium.

In: Nature Genetics, Vol. 51, No. 12, 31.12.2019, p. 1670-1678.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Schizophrenia Working Group of the Psychiatric Genomics Consortium 2019, 'Comparative genetic architectures of schizophrenia in East Asian and European populations', Nature Genetics, vol. 51, no. 12, pp. 1670-1678. https://doi.org/10.1038/s41588-019-0512-x

APA

Schizophrenia Working Group of the Psychiatric Genomics Consortium (2019). Comparative genetic architectures of schizophrenia in East Asian and European populations. Nature Genetics, 51(12), 1670-1678. https://doi.org/10.1038/s41588-019-0512-x

Vancouver

Schizophrenia Working Group of the Psychiatric Genomics Consortium. Comparative genetic architectures of schizophrenia in East Asian and European populations. Nature Genetics. 2019 Dec 31;51(12):1670-1678. https://doi.org/10.1038/s41588-019-0512-x

Author

Schizophrenia Working Group of the Psychiatric Genomics Consortium. / Comparative genetic architectures of schizophrenia in East Asian and European populations. In: Nature Genetics. 2019 ; Vol. 51, No. 12. pp. 1670-1678.

Bibtex

@article{c1823b4fd3bd4110a982ef7d52e9bad2,
title = "Comparative genetic architectures of schizophrenia in East Asian and European populations",
abstract = "Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk globally. Large-scale schizophrenia genetic studies have reported primarily on European ancestry samples, potentially missing important biological insights. Here, we report the largest study to date of East Asian participants (22,778 schizophrenia cases and 35,362 controls), identifying 21 genome-wide-significant associations in 19 genetic loci. Common genetic variants that confer risk for schizophrenia have highly similar effects between East Asian and European ancestries (genetic correlation = 0.98 ± 0.03), indicating that the genetic basis of schizophrenia and its biology are broadly shared across populations. A fixed-effect meta-analysis including individuals from East Asian and European ancestries identified 208 significant associations in 176 genetic loci (53 novel). Trans-ancestry fine-mapping reduced the sets of candidate causal variants in 44 loci. Polygenic risk scores had reduced performance when transferred across ancestries, highlighting the importance of including sufficient samples of major ancestral groups to ensure their generalizability across populations.",
author = "{Schizophrenia Working Group of the Psychiatric Genomics Consortium} and Max Lam and Chia-Yen Chen and Zhiqiang Li and Martin, {Alicia R} and Julien Bryois and Xixian Ma and Helena Gaspar and Masashi Ikeda and Beben Benyamin and Brown, {Brielin C} and Ruize Liu and Wei Zhou and Lili Guan and Yoichiro Kamatani and Sung-Wan Kim and Michiaki Kubo and Kusumawardhani, {Agung A A A} and Chih-Min Liu and Hong Ma and Sathish Periyasamy and Atsushi Takahashi and Zhida Xu and Hao Yu and Feng Zhu and Chen, {Wei J} and Stephen Faraone and Glatt, {Stephen J} and Lin He and Hyman, {Steven E} and Hai-Gwo Hwu and McCarroll, {Steven A} and Neale, {Benjamin M} and Pamela Sklar and Wildenauer, {Dieter B} and Xin Yu and Dai Zhang and Mowry, {Bryan J} and Jimmy Lee and Peter Holmans and Shuhua Xu and Sullivan, {Patrick F} and Stephan Ripke and O'Donovan, {Michael C} and Daly, {Mark J} and Shengying Qin and Pak Sham and Nakao Iwata and Hong, {Kyung S} and Schwab, {Sibylle G} and Weihua Yue and Jo Knight",
year = "2019",
month = dec,
day = "31",
doi = "10.1038/s41588-019-0512-x",
language = "English",
volume = "51",
pages = "1670--1678",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "12",

}

RIS

TY - JOUR

T1 - Comparative genetic architectures of schizophrenia in East Asian and European populations

AU - Schizophrenia Working Group of the Psychiatric Genomics Consortium

AU - Lam, Max

AU - Chen, Chia-Yen

AU - Li, Zhiqiang

AU - Martin, Alicia R

AU - Bryois, Julien

AU - Ma, Xixian

AU - Gaspar, Helena

AU - Ikeda, Masashi

AU - Benyamin, Beben

AU - Brown, Brielin C

AU - Liu, Ruize

AU - Zhou, Wei

AU - Guan, Lili

AU - Kamatani, Yoichiro

AU - Kim, Sung-Wan

AU - Kubo, Michiaki

AU - Kusumawardhani, Agung A A A

AU - Liu, Chih-Min

AU - Ma, Hong

AU - Periyasamy, Sathish

AU - Takahashi, Atsushi

AU - Xu, Zhida

AU - Yu, Hao

AU - Zhu, Feng

AU - Chen, Wei J

AU - Faraone, Stephen

AU - Glatt, Stephen J

AU - He, Lin

AU - Hyman, Steven E

AU - Hwu, Hai-Gwo

AU - McCarroll, Steven A

AU - Neale, Benjamin M

AU - Sklar, Pamela

AU - Wildenauer, Dieter B

AU - Yu, Xin

AU - Zhang, Dai

AU - Mowry, Bryan J

AU - Lee, Jimmy

AU - Holmans, Peter

AU - Xu, Shuhua

AU - Sullivan, Patrick F

AU - Ripke, Stephan

AU - O'Donovan, Michael C

AU - Daly, Mark J

AU - Qin, Shengying

AU - Sham, Pak

AU - Iwata, Nakao

AU - Hong, Kyung S

AU - Schwab, Sibylle G

AU - Yue, Weihua

AU - Knight, Jo

PY - 2019/12/31

Y1 - 2019/12/31

N2 - Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk globally. Large-scale schizophrenia genetic studies have reported primarily on European ancestry samples, potentially missing important biological insights. Here, we report the largest study to date of East Asian participants (22,778 schizophrenia cases and 35,362 controls), identifying 21 genome-wide-significant associations in 19 genetic loci. Common genetic variants that confer risk for schizophrenia have highly similar effects between East Asian and European ancestries (genetic correlation = 0.98 ± 0.03), indicating that the genetic basis of schizophrenia and its biology are broadly shared across populations. A fixed-effect meta-analysis including individuals from East Asian and European ancestries identified 208 significant associations in 176 genetic loci (53 novel). Trans-ancestry fine-mapping reduced the sets of candidate causal variants in 44 loci. Polygenic risk scores had reduced performance when transferred across ancestries, highlighting the importance of including sufficient samples of major ancestral groups to ensure their generalizability across populations.

AB - Schizophrenia is a debilitating psychiatric disorder with approximately 1% lifetime risk globally. Large-scale schizophrenia genetic studies have reported primarily on European ancestry samples, potentially missing important biological insights. Here, we report the largest study to date of East Asian participants (22,778 schizophrenia cases and 35,362 controls), identifying 21 genome-wide-significant associations in 19 genetic loci. Common genetic variants that confer risk for schizophrenia have highly similar effects between East Asian and European ancestries (genetic correlation = 0.98 ± 0.03), indicating that the genetic basis of schizophrenia and its biology are broadly shared across populations. A fixed-effect meta-analysis including individuals from East Asian and European ancestries identified 208 significant associations in 176 genetic loci (53 novel). Trans-ancestry fine-mapping reduced the sets of candidate causal variants in 44 loci. Polygenic risk scores had reduced performance when transferred across ancestries, highlighting the importance of including sufficient samples of major ancestral groups to ensure their generalizability across populations.

U2 - 10.1038/s41588-019-0512-x

DO - 10.1038/s41588-019-0512-x

M3 - Journal article

C2 - 31740837

VL - 51

SP - 1670

EP - 1678

JO - Nature Genetics

JF - Nature Genetics

SN - 1061-4036

IS - 12

ER -