Home > Research > Publications & Outputs > Comparison of behavioural activation with guide...

Associated organisational unit

Links

Text available via DOI:

View graph of relations

Comparison of behavioural activation with guided self-help for treatment of depression in adults with intellectual disabilities: a randomised controlled trial

Research output: Contribution to journalJournal article

Published

Standard

Comparison of behavioural activation with guided self-help for treatment of depression in adults with intellectual disabilities : a randomised controlled trial. / Jahoda, Andrew; Hastings, Richard; Hatton, Chris; Cooper, Sally-Ann; Dagnan, Dave; Zhang, Ruiqi; McConnachie, Alex; McMeekin, Nicola; Appleton, Kim; Jones, Rob; Scott, Katie; Fulton, Lauren; Knight, Rosie; Knowles, Dawn; Williams, Chris; Briggs, Andrew; MacMahon, Ken; Lynn, Helen; Smith, Ian; Thomas, Gail; Melville, Craig.

In: Lancet Psychiatry, Vol. 4, No. 12, 12.2017, p. 909-919.

Research output: Contribution to journalJournal article

Harvard

Jahoda, A, Hastings, R, Hatton, C, Cooper, S-A, Dagnan, D, Zhang, R, McConnachie, A, McMeekin, N, Appleton, K, Jones, R, Scott, K, Fulton, L, Knight, R, Knowles, D, Williams, C, Briggs, A, MacMahon, K, Lynn, H, Smith, I, Thomas, G & Melville, C 2017, 'Comparison of behavioural activation with guided self-help for treatment of depression in adults with intellectual disabilities: a randomised controlled trial', Lancet Psychiatry, vol. 4, no. 12, pp. 909-919. https://doi.org/10.1016/S2215-0366(17)30426-1

APA

Jahoda, A., Hastings, R., Hatton, C., Cooper, S-A., Dagnan, D., Zhang, R., McConnachie, A., McMeekin, N., Appleton, K., Jones, R., Scott, K., Fulton, L., Knight, R., Knowles, D., Williams, C., Briggs, A., MacMahon, K., Lynn, H., Smith, I., ... Melville, C. (2017). Comparison of behavioural activation with guided self-help for treatment of depression in adults with intellectual disabilities: a randomised controlled trial. Lancet Psychiatry, 4(12), 909-919. https://doi.org/10.1016/S2215-0366(17)30426-1

Vancouver

Author

Jahoda, Andrew ; Hastings, Richard ; Hatton, Chris ; Cooper, Sally-Ann ; Dagnan, Dave ; Zhang, Ruiqi ; McConnachie, Alex ; McMeekin, Nicola ; Appleton, Kim ; Jones, Rob ; Scott, Katie ; Fulton, Lauren ; Knight, Rosie ; Knowles, Dawn ; Williams, Chris ; Briggs, Andrew ; MacMahon, Ken ; Lynn, Helen ; Smith, Ian ; Thomas, Gail ; Melville, Craig. / Comparison of behavioural activation with guided self-help for treatment of depression in adults with intellectual disabilities : a randomised controlled trial. In: Lancet Psychiatry. 2017 ; Vol. 4, No. 12. pp. 909-919.

Bibtex

@article{53b89ffbe2454ff3a2e38ca8fc43a70c,
title = "Comparison of behavioural activation with guided self-help for treatment of depression in adults with intellectual disabilities: a randomised controlled trial",
abstract = "Background Psychological therapies are first-line interventions for depression, but existing provision is not accessible for many adults with intellectual disabilities. We investigated the clinical and cost-effectiveness of a behavioural activation intervention (BeatIt) for people with intellectual disabilities and depression. BeatIt was compared with a guided self-help intervention (StepUp). Methods We did a multicentre, single-blind, randomised, controlled trial with follow-up at 4 months and 12 months after randomisation. Participants aged 18 years or older, with mild to moderate intellectual disabilities and clinically significant depression were recruited from health and social care services in the UK. The primary outcome was the Glasgow Depression Scale for people with a Learning Disability (GDS-LD) score at 12 months. Analyses were done on an intention-to-treat basis. This trial is registered with ISCRTN, number ISRCTN09753005. Findings Between Aug 8, 2013, and Sept 1, 2015, 161 participants were randomly assigned (84 to BeatIt; 77 to StepUp); 141 (88%) participants completed the trial. No group differences were found in the effects of BeatIt and StepUp based on GDS-LD scores at 12 months (12·03 [SD 7·99] GDS-LD points for BeatIt vs 12·43 [SD 7·64] GDS-LD points for StepUp; mean difference 0·26 GDS-LD points [95% CI –2·18 to 2·70]; p=0·833). Within-group improvements in GDS-LD scores occurred in both groups at 12 months (BeatIt, mean change –4·2 GDS-LD points [95% CI –6·0 to –2·4], p<0·0001; StepUp, mean change –4·5 GDS-LD points [–6·2 to –2·7], p<0·0001), with large effect sizes (BeatIt, 0·590 [95% CI 0·337–0·844]; StepUp, 0·627 [0·380–0·873]). BeatIt was not cost-effective when compared with StepUp, although the economic analyses indicated substantial uncertainty. Treatment costs were only approximately 3·6–6·8% of participants{\textquoteright} total support costs. No treatment-related or trial-related adverse events were reported. Interpretation This study is, to our knowledge, the first large randomised controlled trial assessing individual psychological interventions for people with intellectual disabilities and mental health problems. These findings show that there is no evidence that BeatIt is more effective than StepUp; both are active and potentially effective interventions.",
author = "Andrew Jahoda and Richard Hastings and Chris Hatton and Sally-Ann Cooper and Dave Dagnan and Ruiqi Zhang and Alex McConnachie and Nicola McMeekin and Kim Appleton and Rob Jones and Katie Scott and Lauren Fulton and Rosie Knight and Dawn Knowles and Chris Williams and Andrew Briggs and Ken MacMahon and Helen Lynn and Ian Smith and Gail Thomas and Craig Melville",
year = "2017",
month = dec,
doi = "10.1016/S2215-0366(17)30426-1",
language = "English",
volume = "4",
pages = "909--919",
journal = "Lancet Psychiatry",
issn = "2215-0366",
publisher = "Elsevier Limited",
number = "12",

}

RIS

TY - JOUR

T1 - Comparison of behavioural activation with guided self-help for treatment of depression in adults with intellectual disabilities

T2 - a randomised controlled trial

AU - Jahoda, Andrew

AU - Hastings, Richard

AU - Hatton, Chris

AU - Cooper, Sally-Ann

AU - Dagnan, Dave

AU - Zhang, Ruiqi

AU - McConnachie, Alex

AU - McMeekin, Nicola

AU - Appleton, Kim

AU - Jones, Rob

AU - Scott, Katie

AU - Fulton, Lauren

AU - Knight, Rosie

AU - Knowles, Dawn

AU - Williams, Chris

AU - Briggs, Andrew

AU - MacMahon, Ken

AU - Lynn, Helen

AU - Smith, Ian

AU - Thomas, Gail

AU - Melville, Craig

PY - 2017/12

Y1 - 2017/12

N2 - Background Psychological therapies are first-line interventions for depression, but existing provision is not accessible for many adults with intellectual disabilities. We investigated the clinical and cost-effectiveness of a behavioural activation intervention (BeatIt) for people with intellectual disabilities and depression. BeatIt was compared with a guided self-help intervention (StepUp). Methods We did a multicentre, single-blind, randomised, controlled trial with follow-up at 4 months and 12 months after randomisation. Participants aged 18 years or older, with mild to moderate intellectual disabilities and clinically significant depression were recruited from health and social care services in the UK. The primary outcome was the Glasgow Depression Scale for people with a Learning Disability (GDS-LD) score at 12 months. Analyses were done on an intention-to-treat basis. This trial is registered with ISCRTN, number ISRCTN09753005. Findings Between Aug 8, 2013, and Sept 1, 2015, 161 participants were randomly assigned (84 to BeatIt; 77 to StepUp); 141 (88%) participants completed the trial. No group differences were found in the effects of BeatIt and StepUp based on GDS-LD scores at 12 months (12·03 [SD 7·99] GDS-LD points for BeatIt vs 12·43 [SD 7·64] GDS-LD points for StepUp; mean difference 0·26 GDS-LD points [95% CI –2·18 to 2·70]; p=0·833). Within-group improvements in GDS-LD scores occurred in both groups at 12 months (BeatIt, mean change –4·2 GDS-LD points [95% CI –6·0 to –2·4], p<0·0001; StepUp, mean change –4·5 GDS-LD points [–6·2 to –2·7], p<0·0001), with large effect sizes (BeatIt, 0·590 [95% CI 0·337–0·844]; StepUp, 0·627 [0·380–0·873]). BeatIt was not cost-effective when compared with StepUp, although the economic analyses indicated substantial uncertainty. Treatment costs were only approximately 3·6–6·8% of participants’ total support costs. No treatment-related or trial-related adverse events were reported. Interpretation This study is, to our knowledge, the first large randomised controlled trial assessing individual psychological interventions for people with intellectual disabilities and mental health problems. These findings show that there is no evidence that BeatIt is more effective than StepUp; both are active and potentially effective interventions.

AB - Background Psychological therapies are first-line interventions for depression, but existing provision is not accessible for many adults with intellectual disabilities. We investigated the clinical and cost-effectiveness of a behavioural activation intervention (BeatIt) for people with intellectual disabilities and depression. BeatIt was compared with a guided self-help intervention (StepUp). Methods We did a multicentre, single-blind, randomised, controlled trial with follow-up at 4 months and 12 months after randomisation. Participants aged 18 years or older, with mild to moderate intellectual disabilities and clinically significant depression were recruited from health and social care services in the UK. The primary outcome was the Glasgow Depression Scale for people with a Learning Disability (GDS-LD) score at 12 months. Analyses were done on an intention-to-treat basis. This trial is registered with ISCRTN, number ISRCTN09753005. Findings Between Aug 8, 2013, and Sept 1, 2015, 161 participants were randomly assigned (84 to BeatIt; 77 to StepUp); 141 (88%) participants completed the trial. No group differences were found in the effects of BeatIt and StepUp based on GDS-LD scores at 12 months (12·03 [SD 7·99] GDS-LD points for BeatIt vs 12·43 [SD 7·64] GDS-LD points for StepUp; mean difference 0·26 GDS-LD points [95% CI –2·18 to 2·70]; p=0·833). Within-group improvements in GDS-LD scores occurred in both groups at 12 months (BeatIt, mean change –4·2 GDS-LD points [95% CI –6·0 to –2·4], p<0·0001; StepUp, mean change –4·5 GDS-LD points [–6·2 to –2·7], p<0·0001), with large effect sizes (BeatIt, 0·590 [95% CI 0·337–0·844]; StepUp, 0·627 [0·380–0·873]). BeatIt was not cost-effective when compared with StepUp, although the economic analyses indicated substantial uncertainty. Treatment costs were only approximately 3·6–6·8% of participants’ total support costs. No treatment-related or trial-related adverse events were reported. Interpretation This study is, to our knowledge, the first large randomised controlled trial assessing individual psychological interventions for people with intellectual disabilities and mental health problems. These findings show that there is no evidence that BeatIt is more effective than StepUp; both are active and potentially effective interventions.

U2 - 10.1016/S2215-0366(17)30426-1

DO - 10.1016/S2215-0366(17)30426-1

M3 - Journal article

VL - 4

SP - 909

EP - 919

JO - Lancet Psychiatry

JF - Lancet Psychiatry

SN - 2215-0366

IS - 12

ER -