Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Complexes in context
T2 - attempting to control the cellular uptake and localisation of rhenium fac-tricarbonyl polypyridyl complexes
AU - Balasingham, Rebeca G.
AU - Coogan, Michael
AU - Thorp-Greenwood, Flora L.
PY - 2011
Y1 - 2011
N2 - Transition metal lumophores are now well established as agents for cell imaging, but we are still not able to predict generally and with confidence their cellular localisation, or, for that matter, their uptake efficiencies. While many such complexes have been shown to illuminate cells, genuine applications in biomedical research will only be developed when their uptake and localisation are better understood. This perspective is not a comprehensive review of luminescence, but is an overview of attempts to control uptake and localisation, focussing on a personal account of this group's development of imaging agents based on the Re(CO)3 bipyridine core, and our attempts to understand and control their cellular behaviour.
AB - Transition metal lumophores are now well established as agents for cell imaging, but we are still not able to predict generally and with confidence their cellular localisation, or, for that matter, their uptake efficiencies. While many such complexes have been shown to illuminate cells, genuine applications in biomedical research will only be developed when their uptake and localisation are better understood. This perspective is not a comprehensive review of luminescence, but is an overview of attempts to control uptake and localisation, focussing on a personal account of this group's development of imaging agents based on the Re(CO)3 bipyridine core, and our attempts to understand and control their cellular behaviour.
U2 - 10.1039/C1DT11219H
DO - 10.1039/C1DT11219H
M3 - Journal article
VL - 40
SP - 11663
EP - 11674
JO - Dalton Transactions
JF - Dalton Transactions
SN - 1477-9234
IS - 44
ER -