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Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migration

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Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migration. / Antonica, Francesco; Orietti, Lorenzo Carlo; Mort, Richard Lester; Zernicka-Goetz, Magdalena.

In: Developmental Biology, Vol. 450, No. 2, 01.06.2019, p. 132-140.

Research output: Contribution to journalJournal article

Harvard

Antonica, F, Orietti, LC, Mort, RL & Zernicka-Goetz, M 2019, 'Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migration', Developmental Biology, vol. 450, no. 2, pp. 132-140. https://doi.org/10.1016/j.ydbio.2019.03.016

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Author

Antonica, Francesco ; Orietti, Lorenzo Carlo ; Mort, Richard Lester ; Zernicka-Goetz, Magdalena. / Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migration. In: Developmental Biology. 2019 ; Vol. 450, No. 2. pp. 132-140.

Bibtex

@article{a6d7b9416e324ae182e7e32575a279cd,
title = "Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migration",
abstract = "Migration of Anterior Visceral Endoderm (AVE) is a critical symmetry breaking event in the early post-implantation embryo development and is essential for establishing the correct body plan. Despite much effort, cellular and molecular events influencing AVE migration are only partially understood. Here, using time-lapse live imaging of mouse embryos, we demonstrate that cell division in the embryonic visceral endoderm is coordinated with AVE migration. Moreover, we demonstrate that temporal inhibition of FGF signalling during the pre-implantation specification of embryonic visceral endoderm perturbs cell cycle progression, thus affecting AVE migration. These findings demonstrate that coordinated cell cycle progression during the implantation stages of development is important for post-implantation morphogenesis in the mouse embryo.",
keywords = "4D live imaging, Mouse embryo, Post-implantation morphogenesis, Visceral endoderm",
author = "Francesco Antonica and Orietti, {Lorenzo Carlo} and Mort, {Richard Lester} and Magdalena Zernicka-Goetz",
year = "2019",
month = "6",
day = "1",
doi = "10.1016/j.ydbio.2019.03.016",
language = "English",
volume = "450",
pages = "132--140",
journal = "Developmental Biology",
issn = "0012-1606",
publisher = "Academic Press Inc.",
number = "2",

}

RIS

TY - JOUR

T1 - Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migration

AU - Antonica, Francesco

AU - Orietti, Lorenzo Carlo

AU - Mort, Richard Lester

AU - Zernicka-Goetz, Magdalena

PY - 2019/6/1

Y1 - 2019/6/1

N2 - Migration of Anterior Visceral Endoderm (AVE) is a critical symmetry breaking event in the early post-implantation embryo development and is essential for establishing the correct body plan. Despite much effort, cellular and molecular events influencing AVE migration are only partially understood. Here, using time-lapse live imaging of mouse embryos, we demonstrate that cell division in the embryonic visceral endoderm is coordinated with AVE migration. Moreover, we demonstrate that temporal inhibition of FGF signalling during the pre-implantation specification of embryonic visceral endoderm perturbs cell cycle progression, thus affecting AVE migration. These findings demonstrate that coordinated cell cycle progression during the implantation stages of development is important for post-implantation morphogenesis in the mouse embryo.

AB - Migration of Anterior Visceral Endoderm (AVE) is a critical symmetry breaking event in the early post-implantation embryo development and is essential for establishing the correct body plan. Despite much effort, cellular and molecular events influencing AVE migration are only partially understood. Here, using time-lapse live imaging of mouse embryos, we demonstrate that cell division in the embryonic visceral endoderm is coordinated with AVE migration. Moreover, we demonstrate that temporal inhibition of FGF signalling during the pre-implantation specification of embryonic visceral endoderm perturbs cell cycle progression, thus affecting AVE migration. These findings demonstrate that coordinated cell cycle progression during the implantation stages of development is important for post-implantation morphogenesis in the mouse embryo.

KW - 4D live imaging

KW - Mouse embryo

KW - Post-implantation morphogenesis

KW - Visceral endoderm

U2 - 10.1016/j.ydbio.2019.03.016

DO - 10.1016/j.ydbio.2019.03.016

M3 - Journal article

C2 - 30940540

VL - 450

SP - 132

EP - 140

JO - Developmental Biology

JF - Developmental Biology

SN - 0012-1606

IS - 2

ER -