Final published version
Licence: CC BY: Creative Commons Attribution 4.0 International License
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Concerted cell divisions in embryonic visceral endoderm guide anterior visceral endoderm migration
AU - Antonica, Francesco
AU - Orietti, Lorenzo Carlo
AU - Mort, Richard Lester
AU - Zernicka-Goetz, Magdalena
PY - 2019/6/1
Y1 - 2019/6/1
N2 - Migration of Anterior Visceral Endoderm (AVE) is a critical symmetry breaking event in the early post-implantation embryo development and is essential for establishing the correct body plan. Despite much effort, cellular and molecular events influencing AVE migration are only partially understood. Here, using time-lapse live imaging of mouse embryos, we demonstrate that cell division in the embryonic visceral endoderm is coordinated with AVE migration. Moreover, we demonstrate that temporal inhibition of FGF signalling during the pre-implantation specification of embryonic visceral endoderm perturbs cell cycle progression, thus affecting AVE migration. These findings demonstrate that coordinated cell cycle progression during the implantation stages of development is important for post-implantation morphogenesis in the mouse embryo.
AB - Migration of Anterior Visceral Endoderm (AVE) is a critical symmetry breaking event in the early post-implantation embryo development and is essential for establishing the correct body plan. Despite much effort, cellular and molecular events influencing AVE migration are only partially understood. Here, using time-lapse live imaging of mouse embryos, we demonstrate that cell division in the embryonic visceral endoderm is coordinated with AVE migration. Moreover, we demonstrate that temporal inhibition of FGF signalling during the pre-implantation specification of embryonic visceral endoderm perturbs cell cycle progression, thus affecting AVE migration. These findings demonstrate that coordinated cell cycle progression during the implantation stages of development is important for post-implantation morphogenesis in the mouse embryo.
KW - 4D live imaging
KW - Mouse embryo
KW - Post-implantation morphogenesis
KW - Visceral endoderm
U2 - 10.1016/j.ydbio.2019.03.016
DO - 10.1016/j.ydbio.2019.03.016
M3 - Journal article
C2 - 30940540
VL - 450
SP - 132
EP - 140
JO - Developmental Biology
JF - Developmental Biology
SN - 0012-1606
IS - 2
ER -