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Conducting polymer-based multilayer films for instructive biomaterial coatings

Research output: Contribution to journalJournal article

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Conducting polymer-based multilayer films for instructive biomaterial coatings. / Hardy, John George; Li, Hetian; Chow, Jacqueline K.; Geissler, Sydney; McElroy, Austin; Nguy, Lindsey; Hernandez, Derek S.; Schmidt, Christine E.

In: Future Science OA, Vol. 1, No. 4, FSO79, 02.11.2015, p. 1.

Research output: Contribution to journalJournal article

Harvard

Hardy, JG, Li, H, Chow, JK, Geissler, S, McElroy, A, Nguy, L, Hernandez, DS & Schmidt, CE 2015, 'Conducting polymer-based multilayer films for instructive biomaterial coatings', Future Science OA, vol. 1, no. 4, FSO79, pp. 1. https://doi.org/10.4155/fso.15.79

APA

Hardy, J. G., Li, H., Chow, J. K., Geissler, S., McElroy, A., Nguy, L., ... Schmidt, C. E. (2015). Conducting polymer-based multilayer films for instructive biomaterial coatings. Future Science OA, 1(4), 1. [FSO79]. https://doi.org/10.4155/fso.15.79

Vancouver

Hardy JG, Li H, Chow JK, Geissler S, McElroy A, Nguy L et al. Conducting polymer-based multilayer films for instructive biomaterial coatings. Future Science OA. 2015 Nov 2;1(4):1. FSO79. https://doi.org/10.4155/fso.15.79

Author

Hardy, John George ; Li, Hetian ; Chow, Jacqueline K. ; Geissler, Sydney ; McElroy, Austin ; Nguy, Lindsey ; Hernandez, Derek S. ; Schmidt, Christine E. / Conducting polymer-based multilayer films for instructive biomaterial coatings. In: Future Science OA. 2015 ; Vol. 1, No. 4. pp. 1.

Bibtex

@article{d137fa92921644359f1a065f63e369fc,
title = "Conducting polymer-based multilayer films for instructive biomaterial coatings",
abstract = "Aim: To demonstrate the design, fabrication and testing of conformable conducting biomaterials that encourage cell alignment. Materials & methods: Thin conducting composite biomaterials based on multilayer films of poly (3,4-ethylenedioxythiophene) derivatives, chitosan and gelatin were prepared in a layer-by-layer fashion. Fibroblasts were observed with fluorescence microscopy and their alignment (relative to the dipping direction and direction of electrical current passed through the films) was determined using ImageJ. Results: Fibroblasts adhered to and proliferated on the films. Fibroblasts aligned with the dipping direction used during film preparation and this was enhanced by a DC current. Conclusion: We report the preparation of conducting polymer-based films that enhance the alignment of fibroblasts on their surface which is an important feature of a variety of tissues. Lay abstract: Cells inhabit environments known as the extracellular matrix (ECM) which consists of a mixture of different biomolecules, and the precise composition and topographical properties are different in different tissues (e.g., bone, brain, muscle, skin). Cells interact intimately with the ECM, not only constructing the biomolecules, but assist its organization in 3D space, and its degradation (which is important for tissue remodeling); reciprocally, cells respond to the ECM (e.g., by modifying their size, shape, etc). Cellular alignment is observed in organs and tissues such as bones, muscles and skin, and this alignment is important for the healthy functioning of the organ/tissue. Here, we present a novel method of aligning cells on biomaterials, simply by applying an electrical current through the biomaterial.",
keywords = "CHEMISTRY, biomaterials, conducting polymers, electroactive polymers, tissue scaffold, Electrical stimulation",
author = "Hardy, {John George} and Hetian Li and Chow, {Jacqueline K.} and Sydney Geissler and Austin McElroy and Lindsey Nguy and Hernandez, {Derek S.} and Schmidt, {Christine E}",
year = "2015",
month = "11",
day = "2",
doi = "10.4155/fso.15.79",
language = "English",
volume = "1",
pages = "1",
journal = "Future Science OA",
issn = "2056-5623",
publisher = "Future Medicine Ltd.",
number = "4",

}

RIS

TY - JOUR

T1 - Conducting polymer-based multilayer films for instructive biomaterial coatings

AU - Hardy, John George

AU - Li, Hetian

AU - Chow, Jacqueline K.

AU - Geissler, Sydney

AU - McElroy, Austin

AU - Nguy, Lindsey

AU - Hernandez, Derek S.

AU - Schmidt, Christine E

PY - 2015/11/2

Y1 - 2015/11/2

N2 - Aim: To demonstrate the design, fabrication and testing of conformable conducting biomaterials that encourage cell alignment. Materials & methods: Thin conducting composite biomaterials based on multilayer films of poly (3,4-ethylenedioxythiophene) derivatives, chitosan and gelatin were prepared in a layer-by-layer fashion. Fibroblasts were observed with fluorescence microscopy and their alignment (relative to the dipping direction and direction of electrical current passed through the films) was determined using ImageJ. Results: Fibroblasts adhered to and proliferated on the films. Fibroblasts aligned with the dipping direction used during film preparation and this was enhanced by a DC current. Conclusion: We report the preparation of conducting polymer-based films that enhance the alignment of fibroblasts on their surface which is an important feature of a variety of tissues. Lay abstract: Cells inhabit environments known as the extracellular matrix (ECM) which consists of a mixture of different biomolecules, and the precise composition and topographical properties are different in different tissues (e.g., bone, brain, muscle, skin). Cells interact intimately with the ECM, not only constructing the biomolecules, but assist its organization in 3D space, and its degradation (which is important for tissue remodeling); reciprocally, cells respond to the ECM (e.g., by modifying their size, shape, etc). Cellular alignment is observed in organs and tissues such as bones, muscles and skin, and this alignment is important for the healthy functioning of the organ/tissue. Here, we present a novel method of aligning cells on biomaterials, simply by applying an electrical current through the biomaterial.

AB - Aim: To demonstrate the design, fabrication and testing of conformable conducting biomaterials that encourage cell alignment. Materials & methods: Thin conducting composite biomaterials based on multilayer films of poly (3,4-ethylenedioxythiophene) derivatives, chitosan and gelatin were prepared in a layer-by-layer fashion. Fibroblasts were observed with fluorescence microscopy and their alignment (relative to the dipping direction and direction of electrical current passed through the films) was determined using ImageJ. Results: Fibroblasts adhered to and proliferated on the films. Fibroblasts aligned with the dipping direction used during film preparation and this was enhanced by a DC current. Conclusion: We report the preparation of conducting polymer-based films that enhance the alignment of fibroblasts on their surface which is an important feature of a variety of tissues. Lay abstract: Cells inhabit environments known as the extracellular matrix (ECM) which consists of a mixture of different biomolecules, and the precise composition and topographical properties are different in different tissues (e.g., bone, brain, muscle, skin). Cells interact intimately with the ECM, not only constructing the biomolecules, but assist its organization in 3D space, and its degradation (which is important for tissue remodeling); reciprocally, cells respond to the ECM (e.g., by modifying their size, shape, etc). Cellular alignment is observed in organs and tissues such as bones, muscles and skin, and this alignment is important for the healthy functioning of the organ/tissue. Here, we present a novel method of aligning cells on biomaterials, simply by applying an electrical current through the biomaterial.

KW - CHEMISTRY

KW - biomaterials

KW - conducting polymers

KW - electroactive polymers

KW - tissue scaffold

KW - Electrical stimulation

U2 - 10.4155/fso.15.79

DO - 10.4155/fso.15.79

M3 - Journal article

VL - 1

SP - 1

JO - Future Science OA

JF - Future Science OA

SN - 2056-5623

IS - 4

M1 - FSO79

ER -