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Controlled release of chlorhexidine diacetate from a porous methacrylate system: Supercritical fluid assisted foaming and impregnation

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<mark>Journal publication date</mark>2007
<mark>Journal</mark>Journal of Pharmaceutical Sciences
Issue number8
Volume96
Number of pages9
Pages (from-to)2048-2056
Publication StatusPublished
<mark>Original language</mark>English

Abstract

The release of chlorhexidine diacetate (CX) from a self-curing polymeric system based on poly(ethylmethacrylate) and tetrahydrofurfurylmethacrylate (PEM/THFM) was developed in this study. Supercritical fluid assisted impregnation and foaming was employed for preparing porous CX-PEM/THFM drug release system. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) show that the crystallinity of CX significantly decreased after supercritical processing, whilst Raman spectroscopy suggested a hydrogen bonding interaction between the CX and PEM in the product. A UV-Vis dissolution study revealed that the drug release rate is almost as seven times faster in the SCF processed drug delivery system than conventional cured samples. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association.