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Controlled release of chlorhexidine diacetate from a porous methacrylate system: Supercritical fluid assisted foaming and impregnation

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Controlled release of chlorhexidine diacetate from a porous methacrylate system: Supercritical fluid assisted foaming and impregnation. / Gong, K.; Braden, M.; Patel, M.P. et al.
In: Journal of Pharmaceutical Sciences, Vol. 96, No. 8, 2007, p. 2048-2056.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Gong, K, Braden, M, Patel, MP, Rehman, IU, Zhang, Z & Darr, JA 2007, 'Controlled release of chlorhexidine diacetate from a porous methacrylate system: Supercritical fluid assisted foaming and impregnation', Journal of Pharmaceutical Sciences, vol. 96, no. 8, pp. 2048-2056. https://doi.org/10.1002/jps.20850

APA

Gong, K., Braden, M., Patel, M. P., Rehman, I. U., Zhang, Z., & Darr, J. A. (2007). Controlled release of chlorhexidine diacetate from a porous methacrylate system: Supercritical fluid assisted foaming and impregnation. Journal of Pharmaceutical Sciences, 96(8), 2048-2056. https://doi.org/10.1002/jps.20850

Vancouver

Gong K, Braden M, Patel MP, Rehman IU, Zhang Z, Darr JA. Controlled release of chlorhexidine diacetate from a porous methacrylate system: Supercritical fluid assisted foaming and impregnation. Journal of Pharmaceutical Sciences. 2007;96(8):2048-2056. doi: 10.1002/jps.20850

Author

Gong, K. ; Braden, M. ; Patel, M.P. et al. / Controlled release of chlorhexidine diacetate from a porous methacrylate system : Supercritical fluid assisted foaming and impregnation. In: Journal of Pharmaceutical Sciences. 2007 ; Vol. 96, No. 8. pp. 2048-2056.

Bibtex

@article{30113667e44d4303837fb9331722f91b,
title = "Controlled release of chlorhexidine diacetate from a porous methacrylate system: Supercritical fluid assisted foaming and impregnation",
abstract = "The release of chlorhexidine diacetate (CX) from a self-curing polymeric system based on poly(ethylmethacrylate) and tetrahydrofurfurylmethacrylate (PEM/THFM) was developed in this study. Supercritical fluid assisted impregnation and foaming was employed for preparing porous CX-PEM/THFM drug release system. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) show that the crystallinity of CX significantly decreased after supercritical processing, whilst Raman spectroscopy suggested a hydrogen bonding interaction between the CX and PEM in the product. A UV-Vis dissolution study revealed that the drug release rate is almost as seven times faster in the SCF processed drug delivery system than conventional cured samples. {\textcopyright} 2007 Wiley-Liss, Inc. and the American Pharmacists Association.",
keywords = "Amorphous, Chlorhexidine diacetate, Controlled release, PEM/THFM, Supercritical fluid, chlorhexidine acetate, methacrylic acid, poly(ethyl methacrylate), tetrahydrofurfurylmethacrylate, unclassified drug, article, controlled release formulation, crystal structure, differential scanning calorimetry, dissolution, drug delivery system, drug formulation, drug release, foaming, Raman spectrometry, supercritical fluid, X ray diffraction",
author = "K. Gong and M. Braden and M.P. Patel and I.U. Rehman and Z. Zhang and J.A. Darr",
year = "2007",
doi = "10.1002/jps.20850",
language = "English",
volume = "96",
pages = "2048--2056",
journal = "Journal of Pharmaceutical Sciences",
issn = "0022-3549",
publisher = "John Wiley and Sons Inc.",
number = "8",

}

RIS

TY - JOUR

T1 - Controlled release of chlorhexidine diacetate from a porous methacrylate system

T2 - Supercritical fluid assisted foaming and impregnation

AU - Gong, K.

AU - Braden, M.

AU - Patel, M.P.

AU - Rehman, I.U.

AU - Zhang, Z.

AU - Darr, J.A.

PY - 2007

Y1 - 2007

N2 - The release of chlorhexidine diacetate (CX) from a self-curing polymeric system based on poly(ethylmethacrylate) and tetrahydrofurfurylmethacrylate (PEM/THFM) was developed in this study. Supercritical fluid assisted impregnation and foaming was employed for preparing porous CX-PEM/THFM drug release system. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) show that the crystallinity of CX significantly decreased after supercritical processing, whilst Raman spectroscopy suggested a hydrogen bonding interaction between the CX and PEM in the product. A UV-Vis dissolution study revealed that the drug release rate is almost as seven times faster in the SCF processed drug delivery system than conventional cured samples. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association.

AB - The release of chlorhexidine diacetate (CX) from a self-curing polymeric system based on poly(ethylmethacrylate) and tetrahydrofurfurylmethacrylate (PEM/THFM) was developed in this study. Supercritical fluid assisted impregnation and foaming was employed for preparing porous CX-PEM/THFM drug release system. X-ray diffraction (XRD) and differential scanning calorimetry (DSC) show that the crystallinity of CX significantly decreased after supercritical processing, whilst Raman spectroscopy suggested a hydrogen bonding interaction between the CX and PEM in the product. A UV-Vis dissolution study revealed that the drug release rate is almost as seven times faster in the SCF processed drug delivery system than conventional cured samples. © 2007 Wiley-Liss, Inc. and the American Pharmacists Association.

KW - Amorphous

KW - Chlorhexidine diacetate

KW - Controlled release

KW - PEM/THFM

KW - Supercritical fluid

KW - chlorhexidine acetate

KW - methacrylic acid

KW - poly(ethyl methacrylate)

KW - tetrahydrofurfurylmethacrylate

KW - unclassified drug

KW - article

KW - controlled release formulation

KW - crystal structure

KW - differential scanning calorimetry

KW - dissolution

KW - drug delivery system

KW - drug formulation

KW - drug release

KW - foaming

KW - Raman spectrometry

KW - supercritical fluid

KW - X ray diffraction

U2 - 10.1002/jps.20850

DO - 10.1002/jps.20850

M3 - Journal article

VL - 96

SP - 2048

EP - 2056

JO - Journal of Pharmaceutical Sciences

JF - Journal of Pharmaceutical Sciences

SN - 0022-3549

IS - 8

ER -