We have over 12,000 students, from over 100 countries, within one of the safest campuses in the UK


97% of Lancaster students go into work or further study within six months of graduating

Home > Research > Publications & Outputs > Copper-catalysed approach to spirocyclic oxindo...
View graph of relations

« Back

Copper-catalysed approach to spirocyclic oxindoles via a direct C-H, Ar-H functionalisation

Research output: Contribution to journalJournal article


Associated organisational unit

<mark>Journal publication date</mark>11/04/2012
<mark>Journal</mark>Tetrahedron Letters
Number of pages3
<mark>Original language</mark>English


A practical and efficient entry to spirocyclic oxindoles from readily accessible anilide precursors, using only catalytic amounts of an inexpensive copper salt together with air as the sole re-oxidant, is described. In addition to providing access to a broad range of spiro-oxindole products, the utility of this method is demonstrated in a formal synthesis of the natural product, horsfiline. (C) 2012 Elsevier Ltd. All rights reserved.