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Copper-catalysed approach to spirocyclic oxindoles via a direct C-H, Ar-H functionalisation

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Copper-catalysed approach to spirocyclic oxindoles via a direct C-H, Ar-H functionalisation. / Moody, Catherine L.; Franckevicius, Vilius; Drouhin, Pauline et al.
In: Tetrahedron Letters, Vol. 53, No. 15, 11.04.2012, p. 1897-1899.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Moody, CL, Franckevicius, V, Drouhin, P, Klein, JEMN & Taylor, RJK 2012, 'Copper-catalysed approach to spirocyclic oxindoles via a direct C-H, Ar-H functionalisation', Tetrahedron Letters, vol. 53, no. 15, pp. 1897-1899. https://doi.org/10.1016/j.tetlet.2012.01.120

APA

Moody, C. L., Franckevicius, V., Drouhin, P., Klein, J. E. M. N., & Taylor, R. J. K. (2012). Copper-catalysed approach to spirocyclic oxindoles via a direct C-H, Ar-H functionalisation. Tetrahedron Letters, 53(15), 1897-1899. https://doi.org/10.1016/j.tetlet.2012.01.120

Vancouver

Moody CL, Franckevicius V, Drouhin P, Klein JEMN, Taylor RJK. Copper-catalysed approach to spirocyclic oxindoles via a direct C-H, Ar-H functionalisation. Tetrahedron Letters. 2012 Apr 11;53(15):1897-1899. doi: 10.1016/j.tetlet.2012.01.120

Author

Moody, Catherine L. ; Franckevicius, Vilius ; Drouhin, Pauline et al. / Copper-catalysed approach to spirocyclic oxindoles via a direct C-H, Ar-H functionalisation. In: Tetrahedron Letters. 2012 ; Vol. 53, No. 15. pp. 1897-1899.

Bibtex

@article{6ca701b81d954c7e8f9b13904e7b5ceb,
title = "Copper-catalysed approach to spirocyclic oxindoles via a direct C-H, Ar-H functionalisation",
abstract = "A practical and efficient entry to spirocyclic oxindoles from readily accessible anilide precursors, using only catalytic amounts of an inexpensive copper salt together with air as the sole re-oxidant, is described. In addition to providing access to a broad range of spiro-oxindole products, the utility of this method is demonstrated in a formal synthesis of the natural product, horsfiline. (C) 2012 Elsevier Ltd. All rights reserved.",
keywords = "ALPHA-ARYLATION, PALLADIUM, CENTERS, SPIROOXINDOLES, Natural product synthesis, ENANTIOSELECTIVE SYNTHESIS, C-H activation, GELSEMINE, DERIVATIVES, SUBSTITUTED OXINDOLES, AMIDES, Copper catalysis, Spirocyclic oxindoles, ANION CAPTURE PROCESSES, Radical cyclisation",
author = "Moody, {Catherine L.} and Vilius Franckevicius and Pauline Drouhin and Klein, {Johannes E. M. N.} and Taylor, {Richard J. K.}",
year = "2012",
month = apr,
day = "11",
doi = "10.1016/j.tetlet.2012.01.120",
language = "English",
volume = "53",
pages = "1897--1899",
journal = "Tetrahedron Letters",
issn = "0040-4039",
publisher = "Elsevier Ltd",
number = "15",

}

RIS

TY - JOUR

T1 - Copper-catalysed approach to spirocyclic oxindoles via a direct C-H, Ar-H functionalisation

AU - Moody, Catherine L.

AU - Franckevicius, Vilius

AU - Drouhin, Pauline

AU - Klein, Johannes E. M. N.

AU - Taylor, Richard J. K.

PY - 2012/4/11

Y1 - 2012/4/11

N2 - A practical and efficient entry to spirocyclic oxindoles from readily accessible anilide precursors, using only catalytic amounts of an inexpensive copper salt together with air as the sole re-oxidant, is described. In addition to providing access to a broad range of spiro-oxindole products, the utility of this method is demonstrated in a formal synthesis of the natural product, horsfiline. (C) 2012 Elsevier Ltd. All rights reserved.

AB - A practical and efficient entry to spirocyclic oxindoles from readily accessible anilide precursors, using only catalytic amounts of an inexpensive copper salt together with air as the sole re-oxidant, is described. In addition to providing access to a broad range of spiro-oxindole products, the utility of this method is demonstrated in a formal synthesis of the natural product, horsfiline. (C) 2012 Elsevier Ltd. All rights reserved.

KW - ALPHA-ARYLATION

KW - PALLADIUM

KW - CENTERS

KW - SPIROOXINDOLES

KW - Natural product synthesis

KW - ENANTIOSELECTIVE SYNTHESIS

KW - C-H activation

KW - GELSEMINE

KW - DERIVATIVES

KW - SUBSTITUTED OXINDOLES

KW - AMIDES

KW - Copper catalysis

KW - Spirocyclic oxindoles

KW - ANION CAPTURE PROCESSES

KW - Radical cyclisation

UR - http://www.scopus.com/inward/record.url?scp=84858159365&partnerID=8YFLogxK

U2 - 10.1016/j.tetlet.2012.01.120

DO - 10.1016/j.tetlet.2012.01.120

M3 - Journal article

VL - 53

SP - 1897

EP - 1899

JO - Tetrahedron Letters

JF - Tetrahedron Letters

SN - 0040-4039

IS - 15

ER -