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Costs of resistance : genetic correlations and potential trade-offs in an insect immune system.

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Costs of resistance : genetic correlations and potential trade-offs in an insect immune system. / Cotter, S. L.; Kruuk, L. E. B.; Wilson, Kenneth.
In: Journal of Evolutionary Biology, Vol. 17, No. 2, 03.2004, p. 421-429.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Cotter, SL, Kruuk, LEB & Wilson, K 2004, 'Costs of resistance : genetic correlations and potential trade-offs in an insect immune system.', Journal of Evolutionary Biology, vol. 17, no. 2, pp. 421-429. https://doi.org/10.1046/j.1420-9101.2003.00655.x

APA

Cotter, S. L., Kruuk, L. E. B., & Wilson, K. (2004). Costs of resistance : genetic correlations and potential trade-offs in an insect immune system. Journal of Evolutionary Biology, 17(2), 421-429. https://doi.org/10.1046/j.1420-9101.2003.00655.x

Vancouver

Cotter SL, Kruuk LEB, Wilson K. Costs of resistance : genetic correlations and potential trade-offs in an insect immune system. Journal of Evolutionary Biology. 2004 Mar;17(2):421-429. doi: 10.1046/j.1420-9101.2003.00655.x

Author

Cotter, S. L. ; Kruuk, L. E. B. ; Wilson, Kenneth. / Costs of resistance : genetic correlations and potential trade-offs in an insect immune system. In: Journal of Evolutionary Biology. 2004 ; Vol. 17, No. 2. pp. 421-429.

Bibtex

@article{1bc0ce53302a46c3a8b29113467d572d,
title = "Costs of resistance : genetic correlations and potential trade-offs in an insect immune system.",
abstract = "Theory predicts that natural selection will erode additive genetic variation in fitness-related traits. However, numerous studies have found considerable heritable variation in traits related to immune function, which should be closely linked to fitness. This could be due to trade-offs maintaining variation in these traits. We used the Egyptian cotton leafworm, Spodoptera littoralis, as a model system to examine the quantitative genetics of insect immune function. We estimated the heritabilities of several different measures of innate immunity and the genetic correlations between these immune traits and a number of life history traits. Our results provide the first evidence for a potential genetic trade-off within the insect immune system, with antibacterial activity (lysozyme-like) exhibiting a significant negative genetic correlation with haemocyte density, which itself is positively genetically correlated with both haemolymph phenoloxidase activity and cuticular melanization. We speculate on a potential trade-off between defence against parasites and predators, mediated by larval colour, and its role in maintaining genetic variation in traits under natural selection.",
author = "Cotter, {S. L.} and Kruuk, {L. E. B.} and Kenneth Wilson",
year = "2004",
month = mar,
doi = "10.1046/j.1420-9101.2003.00655.x",
language = "English",
volume = "17",
pages = "421--429",
journal = "Journal of Evolutionary Biology",
issn = "1420-9101",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - Costs of resistance : genetic correlations and potential trade-offs in an insect immune system.

AU - Cotter, S. L.

AU - Kruuk, L. E. B.

AU - Wilson, Kenneth

PY - 2004/3

Y1 - 2004/3

N2 - Theory predicts that natural selection will erode additive genetic variation in fitness-related traits. However, numerous studies have found considerable heritable variation in traits related to immune function, which should be closely linked to fitness. This could be due to trade-offs maintaining variation in these traits. We used the Egyptian cotton leafworm, Spodoptera littoralis, as a model system to examine the quantitative genetics of insect immune function. We estimated the heritabilities of several different measures of innate immunity and the genetic correlations between these immune traits and a number of life history traits. Our results provide the first evidence for a potential genetic trade-off within the insect immune system, with antibacterial activity (lysozyme-like) exhibiting a significant negative genetic correlation with haemocyte density, which itself is positively genetically correlated with both haemolymph phenoloxidase activity and cuticular melanization. We speculate on a potential trade-off between defence against parasites and predators, mediated by larval colour, and its role in maintaining genetic variation in traits under natural selection.

AB - Theory predicts that natural selection will erode additive genetic variation in fitness-related traits. However, numerous studies have found considerable heritable variation in traits related to immune function, which should be closely linked to fitness. This could be due to trade-offs maintaining variation in these traits. We used the Egyptian cotton leafworm, Spodoptera littoralis, as a model system to examine the quantitative genetics of insect immune function. We estimated the heritabilities of several different measures of innate immunity and the genetic correlations between these immune traits and a number of life history traits. Our results provide the first evidence for a potential genetic trade-off within the insect immune system, with antibacterial activity (lysozyme-like) exhibiting a significant negative genetic correlation with haemocyte density, which itself is positively genetically correlated with both haemolymph phenoloxidase activity and cuticular melanization. We speculate on a potential trade-off between defence against parasites and predators, mediated by larval colour, and its role in maintaining genetic variation in traits under natural selection.

U2 - 10.1046/j.1420-9101.2003.00655.x

DO - 10.1046/j.1420-9101.2003.00655.x

M3 - Journal article

VL - 17

SP - 421

EP - 429

JO - Journal of Evolutionary Biology

JF - Journal of Evolutionary Biology

SN - 1420-9101

IS - 2

ER -