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Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal Death

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Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal Death. / Galimov, Evgeniy R; Pryor, Rosina E; Poole, Sarah E; Benedetto, Alexandre; Pincus, Zachary; Gems, David.

In: Cell Reports, Vol. 22, No. 10, 06.03.2018, p. 2730-2741.

Research output: Contribution to journalJournal articlepeer-review

Harvard

Galimov, ER, Pryor, RE, Poole, SE, Benedetto, A, Pincus, Z & Gems, D 2018, 'Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal Death', Cell Reports, vol. 22, no. 10, pp. 2730-2741. https://doi.org/10.1016/j.celrep.2018.02.050

APA

Galimov, E. R., Pryor, R. E., Poole, S. E., Benedetto, A., Pincus, Z., & Gems, D. (2018). Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal Death. Cell Reports, 22(10), 2730-2741. https://doi.org/10.1016/j.celrep.2018.02.050

Vancouver

Galimov ER, Pryor RE, Poole SE, Benedetto A, Pincus Z, Gems D. Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal Death. Cell Reports. 2018 Mar 6;22(10):2730-2741. https://doi.org/10.1016/j.celrep.2018.02.050

Author

Galimov, Evgeniy R ; Pryor, Rosina E ; Poole, Sarah E ; Benedetto, Alexandre ; Pincus, Zachary ; Gems, David. / Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal Death. In: Cell Reports. 2018 ; Vol. 22, No. 10. pp. 2730-2741.

Bibtex

@article{68b819a7aacf46e2b2414fefb8b5a6b0,
title = "Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal Death",
abstract = "Organismal death is a process of systemic collapse whose mechanisms are less well understood than those of cell death. We previously reported that death in C. elegans is accompanied by a calcium-propagated wave of intestinal necrosis, marked by a wave of blue autofluorescence (death fluorescence). Here, we describe another feature of organismal death, a wave of body wall muscle contraction, or death contraction (DC). This phenomenon is accompanied by a wave of intramuscular Ca2+release and, subsequently, of intestinal necrosis. Correlation of directions of the DC and intestinal necrosis waves implies coupling of these death processes. Long-lived insulin/IGF-1-signaling mutants show reduced DC and delayed intestinal necrosis, suggesting possible resistance to organismal death. DC resembles mammalian rigor mortis, a postmortem necrosis-related process in which Ca2+influx promotes muscle hyper-contraction. In contrast to mammals, DC is an early rather than a late event in C. elegans organismal death. VIDEO ABSTRACT.",
keywords = "aging, ATP, calcium, C. elegans, muscle, necrosis, organismal death, pathology, rigor mortis",
author = "Galimov, {Evgeniy R} and Pryor, {Rosina E} and Poole, {Sarah E} and Alexandre Benedetto and Zachary Pincus and David Gems",
note = "Copyright {\textcopyright} 2018 The Author(s). Published by Elsevier Inc. All rights reserved.",
year = "2018",
month = mar,
day = "6",
doi = "10.1016/j.celrep.2018.02.050",
language = "English",
volume = "22",
pages = "2730--2741",
journal = "Cell Reports",
issn = "2211-1247",
publisher = "Cell Press",
number = "10",

}

RIS

TY - JOUR

T1 - Coupling of Rigor Mortis and Intestinal Necrosis during C. elegans Organismal Death

AU - Galimov, Evgeniy R

AU - Pryor, Rosina E

AU - Poole, Sarah E

AU - Benedetto, Alexandre

AU - Pincus, Zachary

AU - Gems, David

N1 - Copyright © 2018 The Author(s). Published by Elsevier Inc. All rights reserved.

PY - 2018/3/6

Y1 - 2018/3/6

N2 - Organismal death is a process of systemic collapse whose mechanisms are less well understood than those of cell death. We previously reported that death in C. elegans is accompanied by a calcium-propagated wave of intestinal necrosis, marked by a wave of blue autofluorescence (death fluorescence). Here, we describe another feature of organismal death, a wave of body wall muscle contraction, or death contraction (DC). This phenomenon is accompanied by a wave of intramuscular Ca2+release and, subsequently, of intestinal necrosis. Correlation of directions of the DC and intestinal necrosis waves implies coupling of these death processes. Long-lived insulin/IGF-1-signaling mutants show reduced DC and delayed intestinal necrosis, suggesting possible resistance to organismal death. DC resembles mammalian rigor mortis, a postmortem necrosis-related process in which Ca2+influx promotes muscle hyper-contraction. In contrast to mammals, DC is an early rather than a late event in C. elegans organismal death. VIDEO ABSTRACT.

AB - Organismal death is a process of systemic collapse whose mechanisms are less well understood than those of cell death. We previously reported that death in C. elegans is accompanied by a calcium-propagated wave of intestinal necrosis, marked by a wave of blue autofluorescence (death fluorescence). Here, we describe another feature of organismal death, a wave of body wall muscle contraction, or death contraction (DC). This phenomenon is accompanied by a wave of intramuscular Ca2+release and, subsequently, of intestinal necrosis. Correlation of directions of the DC and intestinal necrosis waves implies coupling of these death processes. Long-lived insulin/IGF-1-signaling mutants show reduced DC and delayed intestinal necrosis, suggesting possible resistance to organismal death. DC resembles mammalian rigor mortis, a postmortem necrosis-related process in which Ca2+influx promotes muscle hyper-contraction. In contrast to mammals, DC is an early rather than a late event in C. elegans organismal death. VIDEO ABSTRACT.

KW - aging

KW - ATP

KW - calcium

KW - C. elegans

KW - muscle

KW - necrosis

KW - organismal death

KW - pathology

KW - rigor mortis

U2 - 10.1016/j.celrep.2018.02.050

DO - 10.1016/j.celrep.2018.02.050

M3 - Journal article

C2 - 29514100

VL - 22

SP - 2730

EP - 2741

JO - Cell Reports

JF - Cell Reports

SN - 2211-1247

IS - 10

ER -