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Crystallization of polymorphs: the effect of solvent

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Crystallization of polymorphs: the effect of solvent. / KHOSHKHOO, S; ANWAR, J.
In: Journal of Physics D: Applied Physics, Vol. 26, No. 8B, 14.08.1993, p. B90-B93.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

KHOSHKHOO, S & ANWAR, J 1993, 'Crystallization of polymorphs: the effect of solvent', Journal of Physics D: Applied Physics, vol. 26, no. 8B, pp. B90-B93. https://doi.org/10.1088/0022-3727/26/8B/013

APA

KHOSHKHOO, S., & ANWAR, J. (1993). Crystallization of polymorphs: the effect of solvent. Journal of Physics D: Applied Physics, 26(8B), B90-B93. https://doi.org/10.1088/0022-3727/26/8B/013

Vancouver

KHOSHKHOO S, ANWAR J. Crystallization of polymorphs: the effect of solvent. Journal of Physics D: Applied Physics. 1993 Aug 14;26(8B):B90-B93. doi: 10.1088/0022-3727/26/8B/013

Author

KHOSHKHOO, S ; ANWAR, J. / Crystallization of polymorphs : the effect of solvent. In: Journal of Physics D: Applied Physics. 1993 ; Vol. 26, No. 8B. pp. B90-B93.

Bibtex

@article{ae177ad9487b4004b6d37972c6012c0b,
title = "Crystallization of polymorphs: the effect of solvent",
abstract = "The effect of solvent in crystallization of polymorphs has been studied using the drug sulphathiazole as a model compound. The solubilities of the four polymorphic forms of sulphathiazole were determined as a function of temperature in various solvents. Within the temperature ranges studied, the rank order of solubility of the polymorphs was the same in all solvent systems. On the basis of this knowledge of the temperature dependence of the solubilities, recrystallization experiments, in which the supersaturation was systematically varied, were carried out in an endeavour to isolate each of the polymorphic forms from each solvent system. These recrystallization experiments reveal that not all of the known polymorphic forms can be crystallized from any given solvent by varying the supersaturation. Indeed some solvents selectively favour the crystallization of a particular form or forms. We conclude that thermodynamic effects are not responsible for the selective behaviour of a solvent. A kinetic mechanism is proposed. It is considered that the solvent acts by selective adsorption to certain faces of some of the polymorphs, and thereby either inhibits their nucleation or retards their growth to the advantage of others.",
author = "S KHOSHKHOO and J ANWAR",
year = "1993",
month = aug,
day = "14",
doi = "10.1088/0022-3727/26/8B/013",
language = "English",
volume = "26",
pages = "B90--B93",
journal = "Journal of Physics D: Applied Physics",
issn = "0022-3727",
publisher = "IOP Publishing Ltd",
number = "8B",
note = "2ND INTERNATIONAL WORKSHOP ON THE CRYSTAL GROWTH OF ORGANIC MATERIALS ( CGOM-2 ) ; Conference date: 07-09-1992 Through 11-09-1992",

}

RIS

TY - JOUR

T1 - Crystallization of polymorphs

T2 - 2ND INTERNATIONAL WORKSHOP ON THE CRYSTAL GROWTH OF ORGANIC MATERIALS ( CGOM-2 )

AU - KHOSHKHOO, S

AU - ANWAR, J

PY - 1993/8/14

Y1 - 1993/8/14

N2 - The effect of solvent in crystallization of polymorphs has been studied using the drug sulphathiazole as a model compound. The solubilities of the four polymorphic forms of sulphathiazole were determined as a function of temperature in various solvents. Within the temperature ranges studied, the rank order of solubility of the polymorphs was the same in all solvent systems. On the basis of this knowledge of the temperature dependence of the solubilities, recrystallization experiments, in which the supersaturation was systematically varied, were carried out in an endeavour to isolate each of the polymorphic forms from each solvent system. These recrystallization experiments reveal that not all of the known polymorphic forms can be crystallized from any given solvent by varying the supersaturation. Indeed some solvents selectively favour the crystallization of a particular form or forms. We conclude that thermodynamic effects are not responsible for the selective behaviour of a solvent. A kinetic mechanism is proposed. It is considered that the solvent acts by selective adsorption to certain faces of some of the polymorphs, and thereby either inhibits their nucleation or retards their growth to the advantage of others.

AB - The effect of solvent in crystallization of polymorphs has been studied using the drug sulphathiazole as a model compound. The solubilities of the four polymorphic forms of sulphathiazole were determined as a function of temperature in various solvents. Within the temperature ranges studied, the rank order of solubility of the polymorphs was the same in all solvent systems. On the basis of this knowledge of the temperature dependence of the solubilities, recrystallization experiments, in which the supersaturation was systematically varied, were carried out in an endeavour to isolate each of the polymorphic forms from each solvent system. These recrystallization experiments reveal that not all of the known polymorphic forms can be crystallized from any given solvent by varying the supersaturation. Indeed some solvents selectively favour the crystallization of a particular form or forms. We conclude that thermodynamic effects are not responsible for the selective behaviour of a solvent. A kinetic mechanism is proposed. It is considered that the solvent acts by selective adsorption to certain faces of some of the polymorphs, and thereby either inhibits their nucleation or retards their growth to the advantage of others.

U2 - 10.1088/0022-3727/26/8B/013

DO - 10.1088/0022-3727/26/8B/013

M3 - Journal article

VL - 26

SP - B90-B93

JO - Journal of Physics D: Applied Physics

JF - Journal of Physics D: Applied Physics

SN - 0022-3727

IS - 8B

Y2 - 7 September 1992 through 11 September 1992

ER -