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Cytochrome P1B1 gene (CYP1B1) polymorphisms and ovarian cancer risk: a meta-analysis

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Cytochrome P1B1 gene (CYP1B1) polymorphisms and ovarian cancer risk: a meta-analysis. / Gajjar, Ketan; Owens, Gemma; Sperrin, Matthew et al.
In: Toxicology, Vol. 302, No. 2-3, 16.12.2012, p. 157-162.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Gajjar, K, Owens, G, Sperrin, M, Martin-Hirsch, PL & Martin, FL 2012, 'Cytochrome P1B1 gene (CYP1B1) polymorphisms and ovarian cancer risk: a meta-analysis', Toxicology, vol. 302, no. 2-3, pp. 157-162. https://doi.org/10.1016/j.tox.2012.09.009

APA

Gajjar, K., Owens, G., Sperrin, M., Martin-Hirsch, P. L., & Martin, F. L. (2012). Cytochrome P1B1 gene (CYP1B1) polymorphisms and ovarian cancer risk: a meta-analysis. Toxicology, 302(2-3), 157-162. https://doi.org/10.1016/j.tox.2012.09.009

Vancouver

Gajjar K, Owens G, Sperrin M, Martin-Hirsch PL, Martin FL. Cytochrome P1B1 gene (CYP1B1) polymorphisms and ovarian cancer risk: a meta-analysis. Toxicology. 2012 Dec 16;302(2-3):157-162. doi: 10.1016/j.tox.2012.09.009

Author

Gajjar, Ketan ; Owens, Gemma ; Sperrin, Matthew et al. / Cytochrome P1B1 gene (CYP1B1) polymorphisms and ovarian cancer risk : a meta-analysis. In: Toxicology. 2012 ; Vol. 302, No. 2-3. pp. 157-162.

Bibtex

@article{07275f9e61a2492f95099c2b0aeeabbc,
title = "Cytochrome P1B1 gene (CYP1B1) polymorphisms and ovarian cancer risk: a meta-analysis",
abstract = "CYP1B1 is a key P450 enzyme involved in the metabolism of exogenous and endogenous substrates and plays a key role in hormone-induced carcinogenesis. Risk factors for ovarian cancer are related to hormonal exposure and reproduction, and polymorphisms within genes involved in metabolism of oestrogen and certain xenobiotics may influence the risk of developing ovarian cancer. Current meta-analysis evaluated four CYP1B1 polymorphisms (Leu432Val, Arg48Gly, Ala119Ser and Asn453Ser) for their association with ovarian cancer risk. A search of MEDLINE bibliographic database for the period up to April 2012 identified five studies. With regards to Leu432Val polymorphism, all of the five studies were eligible (1199 cases and 2596 controls) for analysis, while for Arg48Gly (799 cases and 1169 controls), Ala119Ser (799 cases and 1172 controls) and Asn453Ser (361cases and 1577 controls) only two studies were eligible for analysis. Fixed-effect models were used to estimate pooled odds ratios (OR) with 95% confidence intervals (95% CI) and chi-square based Q-test was used to test for heterogeneity. The pooled OR (95% CI) for CYP1B1_Leu432Val polymorphism were 1.1 (0.84-1.31) for heterozygous subjects and 0.82 (0.57-1.17) for homozygous Val subjects. In a recessive model, homozygous carriers of Leu432Val showed a weak trend towards reduced risk as compared to 'wild type' and heterozygous carriers (OR 0.8, 95% CI; 0.66-0.99); however, this association was of limited significance. Regarding Arg48Gly, the pooled OR (95% CI) were 1.06 (0.89-1.27) for heterozygous and 0.98 (1.72-1.33) for homozygous Gly subjects. With respect to Ala119Ser and Asn453Ser, the pooled OR were 1.06 (0.87-1.29) and 1.24 (0.94-1.63) for heterozygous and 1.1 (0.8-1.52) and 1.09 (0.5-2.34) for homozygous respectively. In conclusion, this meta-analysis suggests that CYP1B1 polymorphisms are not associated with ovarian cancer risk. Studies evaluating CYP1B1_Leu432Val polymorphism are required to further elucidate the risk of ovarian cancer with this polymorphism. Additionally, studies amongst Asian and African subjects are required to estimate race-specific effects.",
keywords = "Ala119Ser, Arg48Gly , Asn453Ser , CYP1B1 polymorphism , Leu432Val, Ovarian cancer",
author = "Ketan Gajjar and Gemma Owens and Matthew Sperrin and Martin-Hirsch, {Pierre L} and Martin, {Francis L}",
note = "Copyright {\textcopyright} 2012. Published by Elsevier Ireland Ltd.",
year = "2012",
month = dec,
day = "16",
doi = "10.1016/j.tox.2012.09.009",
language = "English",
volume = "302",
pages = "157--162",
journal = "Toxicology",
publisher = "Elsevier Ireland Ltd",
number = "2-3",

}

RIS

TY - JOUR

T1 - Cytochrome P1B1 gene (CYP1B1) polymorphisms and ovarian cancer risk

T2 - a meta-analysis

AU - Gajjar, Ketan

AU - Owens, Gemma

AU - Sperrin, Matthew

AU - Martin-Hirsch, Pierre L

AU - Martin, Francis L

N1 - Copyright © 2012. Published by Elsevier Ireland Ltd.

PY - 2012/12/16

Y1 - 2012/12/16

N2 - CYP1B1 is a key P450 enzyme involved in the metabolism of exogenous and endogenous substrates and plays a key role in hormone-induced carcinogenesis. Risk factors for ovarian cancer are related to hormonal exposure and reproduction, and polymorphisms within genes involved in metabolism of oestrogen and certain xenobiotics may influence the risk of developing ovarian cancer. Current meta-analysis evaluated four CYP1B1 polymorphisms (Leu432Val, Arg48Gly, Ala119Ser and Asn453Ser) for their association with ovarian cancer risk. A search of MEDLINE bibliographic database for the period up to April 2012 identified five studies. With regards to Leu432Val polymorphism, all of the five studies were eligible (1199 cases and 2596 controls) for analysis, while for Arg48Gly (799 cases and 1169 controls), Ala119Ser (799 cases and 1172 controls) and Asn453Ser (361cases and 1577 controls) only two studies were eligible for analysis. Fixed-effect models were used to estimate pooled odds ratios (OR) with 95% confidence intervals (95% CI) and chi-square based Q-test was used to test for heterogeneity. The pooled OR (95% CI) for CYP1B1_Leu432Val polymorphism were 1.1 (0.84-1.31) for heterozygous subjects and 0.82 (0.57-1.17) for homozygous Val subjects. In a recessive model, homozygous carriers of Leu432Val showed a weak trend towards reduced risk as compared to 'wild type' and heterozygous carriers (OR 0.8, 95% CI; 0.66-0.99); however, this association was of limited significance. Regarding Arg48Gly, the pooled OR (95% CI) were 1.06 (0.89-1.27) for heterozygous and 0.98 (1.72-1.33) for homozygous Gly subjects. With respect to Ala119Ser and Asn453Ser, the pooled OR were 1.06 (0.87-1.29) and 1.24 (0.94-1.63) for heterozygous and 1.1 (0.8-1.52) and 1.09 (0.5-2.34) for homozygous respectively. In conclusion, this meta-analysis suggests that CYP1B1 polymorphisms are not associated with ovarian cancer risk. Studies evaluating CYP1B1_Leu432Val polymorphism are required to further elucidate the risk of ovarian cancer with this polymorphism. Additionally, studies amongst Asian and African subjects are required to estimate race-specific effects.

AB - CYP1B1 is a key P450 enzyme involved in the metabolism of exogenous and endogenous substrates and plays a key role in hormone-induced carcinogenesis. Risk factors for ovarian cancer are related to hormonal exposure and reproduction, and polymorphisms within genes involved in metabolism of oestrogen and certain xenobiotics may influence the risk of developing ovarian cancer. Current meta-analysis evaluated four CYP1B1 polymorphisms (Leu432Val, Arg48Gly, Ala119Ser and Asn453Ser) for their association with ovarian cancer risk. A search of MEDLINE bibliographic database for the period up to April 2012 identified five studies. With regards to Leu432Val polymorphism, all of the five studies were eligible (1199 cases and 2596 controls) for analysis, while for Arg48Gly (799 cases and 1169 controls), Ala119Ser (799 cases and 1172 controls) and Asn453Ser (361cases and 1577 controls) only two studies were eligible for analysis. Fixed-effect models were used to estimate pooled odds ratios (OR) with 95% confidence intervals (95% CI) and chi-square based Q-test was used to test for heterogeneity. The pooled OR (95% CI) for CYP1B1_Leu432Val polymorphism were 1.1 (0.84-1.31) for heterozygous subjects and 0.82 (0.57-1.17) for homozygous Val subjects. In a recessive model, homozygous carriers of Leu432Val showed a weak trend towards reduced risk as compared to 'wild type' and heterozygous carriers (OR 0.8, 95% CI; 0.66-0.99); however, this association was of limited significance. Regarding Arg48Gly, the pooled OR (95% CI) were 1.06 (0.89-1.27) for heterozygous and 0.98 (1.72-1.33) for homozygous Gly subjects. With respect to Ala119Ser and Asn453Ser, the pooled OR were 1.06 (0.87-1.29) and 1.24 (0.94-1.63) for heterozygous and 1.1 (0.8-1.52) and 1.09 (0.5-2.34) for homozygous respectively. In conclusion, this meta-analysis suggests that CYP1B1 polymorphisms are not associated with ovarian cancer risk. Studies evaluating CYP1B1_Leu432Val polymorphism are required to further elucidate the risk of ovarian cancer with this polymorphism. Additionally, studies amongst Asian and African subjects are required to estimate race-specific effects.

KW - Ala119Ser

KW - Arg48Gly

KW - Asn453Ser

KW - CYP1B1 polymorphism

KW - Leu432Val

KW - Ovarian cancer

U2 - 10.1016/j.tox.2012.09.009

DO - 10.1016/j.tox.2012.09.009

M3 - Journal article

C2 - 23032576

VL - 302

SP - 157

EP - 162

JO - Toxicology

JF - Toxicology

IS - 2-3

ER -