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DA-JC1 improves learning and memory by antagonizing Aβ31-35-induced circadian rhythm disorder

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DA-JC1 improves learning and memory by antagonizing Aβ31-35-induced circadian rhythm disorder. / Wang, Li; Zhang, Rui; Hou, Xiaohong; Wang, Changtu; Guo, Shuai; Ning, Na; Sun, Cong; Yuan, Yuan; Li, Lin; Hölscher, Christian; Wang, Xiaohui.

In: Molecular Brain, Vol. 12, No. 1, 12, 11.02.2019.

Research output: Contribution to journalJournal article

Harvard

Wang, L, Zhang, R, Hou, X, Wang, C, Guo, S, Ning, N, Sun, C, Yuan, Y, Li, L, Hölscher, C & Wang, X 2019, 'DA-JC1 improves learning and memory by antagonizing Aβ31-35-induced circadian rhythm disorder', Molecular Brain, vol. 12, no. 1, 12. https://doi.org/10.1186/s13041-019-0432-9

APA

Wang, L., Zhang, R., Hou, X., Wang, C., Guo, S., Ning, N., Sun, C., Yuan, Y., Li, L., Hölscher, C., & Wang, X. (2019). DA-JC1 improves learning and memory by antagonizing Aβ31-35-induced circadian rhythm disorder. Molecular Brain, 12(1), [12]. https://doi.org/10.1186/s13041-019-0432-9

Vancouver

Wang L, Zhang R, Hou X, Wang C, Guo S, Ning N et al. DA-JC1 improves learning and memory by antagonizing Aβ31-35-induced circadian rhythm disorder. Molecular Brain. 2019 Feb 11;12(1). 12. https://doi.org/10.1186/s13041-019-0432-9

Author

Wang, Li ; Zhang, Rui ; Hou, Xiaohong ; Wang, Changtu ; Guo, Shuai ; Ning, Na ; Sun, Cong ; Yuan, Yuan ; Li, Lin ; Hölscher, Christian ; Wang, Xiaohui. / DA-JC1 improves learning and memory by antagonizing Aβ31-35-induced circadian rhythm disorder. In: Molecular Brain. 2019 ; Vol. 12, No. 1.

Bibtex

@article{4e49e20b26524f08ad51b8ac84b1aa7a,
title = "DA-JC1 improves learning and memory by antagonizing Aβ31-35-induced circadian rhythm disorder",
abstract = "Studies have shown that a normal circadian rhythm is crucial to learning and memory. Circadian rhythm disturbances that occur at early stages of Alzheimer's disease (AD) aggravate the progression of the disease and further reduce learning and memory in AD patients. The novel, dual GLP-1R/GIPR agonist DA-JC1 has been found to exert a stronger hypoglycemic effect than a GLP-1R agonist alone and has been shown to exert neuroprotective effects. However, it is not clear whether DA-JC1 improves the Aβ31-35-induced decline in learning and memory ability by restoring disrupted circadian rhythms. In the present study, we carried out a mouse wheel-running experiment and Morris water maze test (MWM) and found that DA-JC1 could effectively improve the decline of learning and memory and circadian rhythm disorders induced by Aβ31-35. After downregulating Per2 expression via lentivirus-shPer2 in the hippocampus and the hippocampal HT22 cells, we found that circadian rhythm disorders occurred, and that DA-JC1 could not improve the impaired learning and memory. These results suggest that DA-JC1 improves damage to learning and memory by antagonizing circadian rhythm disorders induced by Aβ31-35. The outcome of this ongoing study may provide a novel therapeutic intervention for AD in the future. {\textcopyright} 2019 The Author(s).",
keywords = "Aβ31-35, Circadian rhythm, DA-JC1, Learning and memory",
author = "Li Wang and Rui Zhang and Xiaohong Hou and Changtu Wang and Shuai Guo and Na Ning and Cong Sun and Yuan Yuan and Lin Li and Christian H{\"o}lscher and Xiaohui Wang",
year = "2019",
month = feb
day = "11",
doi = "10.1186/s13041-019-0432-9",
language = "English",
volume = "12",
journal = "Molecular Brain",
issn = "1756-6606",
publisher = "BIOMED CENTRAL LTD",
number = "1",

}

RIS

TY - JOUR

T1 - DA-JC1 improves learning and memory by antagonizing Aβ31-35-induced circadian rhythm disorder

AU - Wang, Li

AU - Zhang, Rui

AU - Hou, Xiaohong

AU - Wang, Changtu

AU - Guo, Shuai

AU - Ning, Na

AU - Sun, Cong

AU - Yuan, Yuan

AU - Li, Lin

AU - Hölscher, Christian

AU - Wang, Xiaohui

PY - 2019/2/11

Y1 - 2019/2/11

N2 - Studies have shown that a normal circadian rhythm is crucial to learning and memory. Circadian rhythm disturbances that occur at early stages of Alzheimer's disease (AD) aggravate the progression of the disease and further reduce learning and memory in AD patients. The novel, dual GLP-1R/GIPR agonist DA-JC1 has been found to exert a stronger hypoglycemic effect than a GLP-1R agonist alone and has been shown to exert neuroprotective effects. However, it is not clear whether DA-JC1 improves the Aβ31-35-induced decline in learning and memory ability by restoring disrupted circadian rhythms. In the present study, we carried out a mouse wheel-running experiment and Morris water maze test (MWM) and found that DA-JC1 could effectively improve the decline of learning and memory and circadian rhythm disorders induced by Aβ31-35. After downregulating Per2 expression via lentivirus-shPer2 in the hippocampus and the hippocampal HT22 cells, we found that circadian rhythm disorders occurred, and that DA-JC1 could not improve the impaired learning and memory. These results suggest that DA-JC1 improves damage to learning and memory by antagonizing circadian rhythm disorders induced by Aβ31-35. The outcome of this ongoing study may provide a novel therapeutic intervention for AD in the future. © 2019 The Author(s).

AB - Studies have shown that a normal circadian rhythm is crucial to learning and memory. Circadian rhythm disturbances that occur at early stages of Alzheimer's disease (AD) aggravate the progression of the disease and further reduce learning and memory in AD patients. The novel, dual GLP-1R/GIPR agonist DA-JC1 has been found to exert a stronger hypoglycemic effect than a GLP-1R agonist alone and has been shown to exert neuroprotective effects. However, it is not clear whether DA-JC1 improves the Aβ31-35-induced decline in learning and memory ability by restoring disrupted circadian rhythms. In the present study, we carried out a mouse wheel-running experiment and Morris water maze test (MWM) and found that DA-JC1 could effectively improve the decline of learning and memory and circadian rhythm disorders induced by Aβ31-35. After downregulating Per2 expression via lentivirus-shPer2 in the hippocampus and the hippocampal HT22 cells, we found that circadian rhythm disorders occurred, and that DA-JC1 could not improve the impaired learning and memory. These results suggest that DA-JC1 improves damage to learning and memory by antagonizing circadian rhythm disorders induced by Aβ31-35. The outcome of this ongoing study may provide a novel therapeutic intervention for AD in the future. © 2019 The Author(s).

KW - Aβ31-35

KW - Circadian rhythm

KW - DA-JC1

KW - Learning and memory

U2 - 10.1186/s13041-019-0432-9

DO - 10.1186/s13041-019-0432-9

M3 - Journal article

VL - 12

JO - Molecular Brain

JF - Molecular Brain

SN - 1756-6606

IS - 1

M1 - 12

ER -