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Decreased α-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson’s disease.

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Decreased α-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson’s disease. / Tokuda, Takahiko; Salem, Sultan A.; Allsop, David; Mizuno, Toshiki; Nakagawa, Masanori; Qureshi, Mohamed M.; Locascio, Joseph J.; Schlossmacher, Michael G.; El-Agnaf, Omar.

In: Biochemical and Biophysical Research Communications, Vol. 349, No. 1, 13.10.2006, p. 162-166.

Research output: Contribution to journalJournal article

Harvard

Tokuda, T, Salem, SA, Allsop, D, Mizuno, T, Nakagawa, M, Qureshi, MM, Locascio, JJ, Schlossmacher, MG & El-Agnaf, O 2006, 'Decreased α-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson’s disease.', Biochemical and Biophysical Research Communications, vol. 349, no. 1, pp. 162-166. https://doi.org/10.1016/j.bbrc.2006.08.024

APA

Tokuda, T., Salem, S. A., Allsop, D., Mizuno, T., Nakagawa, M., Qureshi, M. M., ... El-Agnaf, O. (2006). Decreased α-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson’s disease. Biochemical and Biophysical Research Communications, 349(1), 162-166. https://doi.org/10.1016/j.bbrc.2006.08.024

Vancouver

Tokuda T, Salem SA, Allsop D, Mizuno T, Nakagawa M, Qureshi MM et al. Decreased α-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson’s disease. Biochemical and Biophysical Research Communications. 2006 Oct 13;349(1):162-166. https://doi.org/10.1016/j.bbrc.2006.08.024

Author

Tokuda, Takahiko ; Salem, Sultan A. ; Allsop, David ; Mizuno, Toshiki ; Nakagawa, Masanori ; Qureshi, Mohamed M. ; Locascio, Joseph J. ; Schlossmacher, Michael G. ; El-Agnaf, Omar. / Decreased α-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson’s disease. In: Biochemical and Biophysical Research Communications. 2006 ; Vol. 349, No. 1. pp. 162-166.

Bibtex

@article{071b07e339a443e49ae767b862dd2cce,
title = "Decreased α-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson’s disease.",
abstract = "There is ample biochemical, pathological, and genetic evidence that the metabolism of -synuclein (-syn) plays a crucial role in the pathogenesis of Parkinson disease (PD). To examine whether quantification of -syn in cerebrospinal fluid (CSF) is potentially informative in the diagnosis of PD, we developed a specific ELISA system and measured the concentration of -syn in CSF from 33 patients with PD (diagnosed according to UK PD Society Brain Bank criteria) and 38 control subjects including 9 neurologically healthy individuals. We found that PD patients had significantly lower -syn levels in their CSF than the control groups (p < 0.0001) even after adjusting for gender and age. Age was independently associated with lower -syn levels. Logistic regression analysis showed that reduction in CSF -syn served as a significant predictor of PD beyond age and gender alone (area under ROC curve, c = 0.882). Furthermore, we observed a close inverse correlation between -syn levels in CSF and assigned Hoehn and Yahr score in this cohort of 71 living subjects (p < 0.0001), even after adjusting for age. These findings identify in the quantification of -syn from CSF a potential laboratory marker to aid the clinical diagnosis of PD.",
keywords = "Parkinson disease, Neurodegenerative diseases, -Synuclein, Cerebrospinal fluid, ELISA, Biomarker, Diagnosis",
author = "Takahiko Tokuda and Salem, {Sultan A.} and David Allsop and Toshiki Mizuno and Masanori Nakagawa and Qureshi, {Mohamed M.} and Locascio, {Joseph J.} and Schlossmacher, {Michael G.} and Omar El-Agnaf",
year = "2006",
month = "10",
day = "13",
doi = "10.1016/j.bbrc.2006.08.024",
language = "English",
volume = "349",
pages = "162--166",
journal = "Biochemical and Biophysical Research Communications",
issn = "0006-291X",
publisher = "Academic Press Inc.",
number = "1",

}

RIS

TY - JOUR

T1 - Decreased α-synuclein in cerebrospinal fluid of aged individuals and subjects with Parkinson’s disease.

AU - Tokuda, Takahiko

AU - Salem, Sultan A.

AU - Allsop, David

AU - Mizuno, Toshiki

AU - Nakagawa, Masanori

AU - Qureshi, Mohamed M.

AU - Locascio, Joseph J.

AU - Schlossmacher, Michael G.

AU - El-Agnaf, Omar

PY - 2006/10/13

Y1 - 2006/10/13

N2 - There is ample biochemical, pathological, and genetic evidence that the metabolism of -synuclein (-syn) plays a crucial role in the pathogenesis of Parkinson disease (PD). To examine whether quantification of -syn in cerebrospinal fluid (CSF) is potentially informative in the diagnosis of PD, we developed a specific ELISA system and measured the concentration of -syn in CSF from 33 patients with PD (diagnosed according to UK PD Society Brain Bank criteria) and 38 control subjects including 9 neurologically healthy individuals. We found that PD patients had significantly lower -syn levels in their CSF than the control groups (p < 0.0001) even after adjusting for gender and age. Age was independently associated with lower -syn levels. Logistic regression analysis showed that reduction in CSF -syn served as a significant predictor of PD beyond age and gender alone (area under ROC curve, c = 0.882). Furthermore, we observed a close inverse correlation between -syn levels in CSF and assigned Hoehn and Yahr score in this cohort of 71 living subjects (p < 0.0001), even after adjusting for age. These findings identify in the quantification of -syn from CSF a potential laboratory marker to aid the clinical diagnosis of PD.

AB - There is ample biochemical, pathological, and genetic evidence that the metabolism of -synuclein (-syn) plays a crucial role in the pathogenesis of Parkinson disease (PD). To examine whether quantification of -syn in cerebrospinal fluid (CSF) is potentially informative in the diagnosis of PD, we developed a specific ELISA system and measured the concentration of -syn in CSF from 33 patients with PD (diagnosed according to UK PD Society Brain Bank criteria) and 38 control subjects including 9 neurologically healthy individuals. We found that PD patients had significantly lower -syn levels in their CSF than the control groups (p < 0.0001) even after adjusting for gender and age. Age was independently associated with lower -syn levels. Logistic regression analysis showed that reduction in CSF -syn served as a significant predictor of PD beyond age and gender alone (area under ROC curve, c = 0.882). Furthermore, we observed a close inverse correlation between -syn levels in CSF and assigned Hoehn and Yahr score in this cohort of 71 living subjects (p < 0.0001), even after adjusting for age. These findings identify in the quantification of -syn from CSF a potential laboratory marker to aid the clinical diagnosis of PD.

KW - Parkinson disease

KW - Neurodegenerative diseases

KW - -Synuclein

KW - Cerebrospinal fluid

KW - ELISA

KW - Biomarker

KW - Diagnosis

U2 - 10.1016/j.bbrc.2006.08.024

DO - 10.1016/j.bbrc.2006.08.024

M3 - Journal article

VL - 349

SP - 162

EP - 166

JO - Biochemical and Biophysical Research Communications

JF - Biochemical and Biophysical Research Communications

SN - 0006-291X

IS - 1

ER -