Final published version
Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Dental materials for cleft palate repair
AU - Sharif, F.
AU - Ur Rehman, I.
AU - Muhammad, N.
AU - MacNeil, S.
PY - 2016/4/1
Y1 - 2016/4/1
N2 - Numerous bone and soft tissue grafting techniques are followed to repair cleft of lip and palate (CLP) defects. In addition to the gold standard surgical interventions involving the use of autogenous grafts, various allogenic and xenogenic graft materials are available for bone regeneration. In an attempt to discover minimally invasive and cost effective treatments for cleft repair, an exceptional growth in synthetic biomedical graft materials have occurred. This study gives an overview of the use of dental materials to repair cleft of lip and palate (CLP). The eligibility criteria for this review were case studies, clinical trials and retrospective studies on the use of various types of dental materials in surgical repair of cleft palate defects. Any data available on the surgical interventions to repair alveolar or palatal cleft, with natural or synthetic graft materials was included in this review. Those datasets with long term clinical follow-up results were referred to as particularly relevant. The results provide encouraging evidence in favor of dental and other related biomedical materials to fill the gaps in clefts of lip and palate. The review presents the various bones and soft tissue replacement strategies currently used, tested or explored for the repair of cleft defects. There was little available data on the use of synthetic materials in cleft repair which was a limitation of this study. In conclusion although clinical trials on the use of synthetic materials are currently underway the uses of autologous implants are the preferred treatment methods to date. © 2015 Elsevier B.V. All rights reserved.
AB - Numerous bone and soft tissue grafting techniques are followed to repair cleft of lip and palate (CLP) defects. In addition to the gold standard surgical interventions involving the use of autogenous grafts, various allogenic and xenogenic graft materials are available for bone regeneration. In an attempt to discover minimally invasive and cost effective treatments for cleft repair, an exceptional growth in synthetic biomedical graft materials have occurred. This study gives an overview of the use of dental materials to repair cleft of lip and palate (CLP). The eligibility criteria for this review were case studies, clinical trials and retrospective studies on the use of various types of dental materials in surgical repair of cleft palate defects. Any data available on the surgical interventions to repair alveolar or palatal cleft, with natural or synthetic graft materials was included in this review. Those datasets with long term clinical follow-up results were referred to as particularly relevant. The results provide encouraging evidence in favor of dental and other related biomedical materials to fill the gaps in clefts of lip and palate. The review presents the various bones and soft tissue replacement strategies currently used, tested or explored for the repair of cleft defects. There was little available data on the use of synthetic materials in cleft repair which was a limitation of this study. In conclusion although clinical trials on the use of synthetic materials are currently underway the uses of autologous implants are the preferred treatment methods to date. © 2015 Elsevier B.V. All rights reserved.
KW - Bone substitute
KW - Cleft palate
KW - Craniofacial repair
KW - Dental materials
KW - Synthetic graft
KW - Biomedical engineering
KW - Bone
KW - Cost effectiveness
KW - Repair
KW - Surgery
KW - Tissue
KW - Bone substitutes
KW - Cost effective treatments
KW - Craniofacial
KW - Eligibility criterion
KW - Grafting techniques
KW - Surgical interventions
KW - Synthetic grafts
KW - Defects
KW - biomaterial
KW - biopolymer
KW - bone prosthesis
KW - dental material
KW - ceramics
KW - chemistry
KW - cleft palate
KW - cytology
KW - human
KW - mesenchymal stem cell transplantation
KW - mesenchymal stroma cell
KW - therapeutic use
KW - Biocompatible Materials
KW - Biopolymers
KW - Bone Substitutes
KW - Ceramics
KW - Cleft Palate
KW - Dental Materials
KW - Humans
KW - Mesenchymal Stem Cell Transplantation
KW - Mesenchymal Stromal Cells
U2 - 10.1016/j.msec.2015.12.019
DO - 10.1016/j.msec.2015.12.019
M3 - Journal article
VL - 61
SP - 1018
EP - 1028
JO - Materials Science and Engineering: A
JF - Materials Science and Engineering: A
SN - 0921-5093
ER -