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Development and automation of a novel [18F]Fprosthetic group, 2-[18F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Development and automation of a novel [18F]Fprosthetic group, 2-[18F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide. / Morris, Olivia; Gregory, J.; Kadirvel, M. et al.
In: Applied Radiation and Isotopes, Vol. 116, 10.2016, p. 120-127.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Morris, O, Gregory, J, Kadirvel, M, Henderson, F, Blykers, A, McMahon, A, Taylor, MN, Allsop, D, Allan, S, Grigg, J, Boutin, H & Prenant, C 2016, 'Development and automation of a novel [18F]Fprosthetic group, 2-[18F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide', Applied Radiation and Isotopes, vol. 116, pp. 120-127. https://doi.org/10.1016/j.apradiso.2016.07.023

APA

Morris, O., Gregory, J., Kadirvel, M., Henderson, F., Blykers, A., McMahon, A., Taylor, M. N., Allsop, D., Allan, S., Grigg, J., Boutin, H., & Prenant, C. (2016). Development and automation of a novel [18F]Fprosthetic group, 2-[18F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide. Applied Radiation and Isotopes, 116, 120-127. https://doi.org/10.1016/j.apradiso.2016.07.023

Vancouver

Morris O, Gregory J, Kadirvel M, Henderson F, Blykers A, McMahon A et al. Development and automation of a novel [18F]Fprosthetic group, 2-[18F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide. Applied Radiation and Isotopes. 2016 Oct;116:120-127. Epub 2016 Jul 27. doi: 10.1016/j.apradiso.2016.07.023

Author

Morris, Olivia ; Gregory, J. ; Kadirvel, M. et al. / Development and automation of a novel [18F]Fprosthetic group, 2-[18F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide. In: Applied Radiation and Isotopes. 2016 ; Vol. 116. pp. 120-127.

Bibtex

@article{1dac85a57e2841eba9d62f4d3c87750f,
title = "Development and automation of a novel [18F]Fprosthetic group, 2-[18F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide",
abstract = "2-[18F]-Fluoro-3-pyridinecarboxaldehyde ([18F]FPCA) is a novel, water-soluble prosthetic group. It's radiochemistry has been developed and fully-automated for application in chemoselective radiolabelling of amino(oxy)-derivatised RI-OR2-TAT peptide, (Aoa-k)-RI-OR2-TAT, using a GE TRACERlab FX-FN. RI-OR2-TAT is a brain-penetrant, retro-inverso peptide that binds to amyloid species associated with Alzheimer's Disease. Radiolabelled (Aoa-k)-RI-OR2-TAT was reproducibly synthesised and the product of the reaction with FPCA has been fully characterised. In-vivo biodistribution of [18F]RI-OR2-TAT has been measured in Wistar rats.",
keywords = "[18F]F prosthetic group, PET, Aβ peptide, Chemical ligation, Oxime bond",
author = "Olivia Morris and J. Gregory and M. Kadirvel and Fiona Henderson and A. Blykers and Adam McMahon and Taylor, {Mark Neville} and David Allsop and Stuart Allan and J. Grigg and Herve Boutin and Christian Prenant",
year = "2016",
month = oct,
doi = "10.1016/j.apradiso.2016.07.023",
language = "English",
volume = "116",
pages = "120--127",
journal = "Applied Radiation and Isotopes",
issn = "0969-8043",
publisher = "Elsevier Limited",

}

RIS

TY - JOUR

T1 - Development and automation of a novel [18F]Fprosthetic group, 2-[18F]-fluoro-3-pyridinecarboxaldehyde, and its application to an amino(oxy)-functionalised Aβ peptide

AU - Morris, Olivia

AU - Gregory, J.

AU - Kadirvel, M.

AU - Henderson, Fiona

AU - Blykers, A.

AU - McMahon, Adam

AU - Taylor, Mark Neville

AU - Allsop, David

AU - Allan, Stuart

AU - Grigg, J.

AU - Boutin, Herve

AU - Prenant, Christian

PY - 2016/10

Y1 - 2016/10

N2 - 2-[18F]-Fluoro-3-pyridinecarboxaldehyde ([18F]FPCA) is a novel, water-soluble prosthetic group. It's radiochemistry has been developed and fully-automated for application in chemoselective radiolabelling of amino(oxy)-derivatised RI-OR2-TAT peptide, (Aoa-k)-RI-OR2-TAT, using a GE TRACERlab FX-FN. RI-OR2-TAT is a brain-penetrant, retro-inverso peptide that binds to amyloid species associated with Alzheimer's Disease. Radiolabelled (Aoa-k)-RI-OR2-TAT was reproducibly synthesised and the product of the reaction with FPCA has been fully characterised. In-vivo biodistribution of [18F]RI-OR2-TAT has been measured in Wistar rats.

AB - 2-[18F]-Fluoro-3-pyridinecarboxaldehyde ([18F]FPCA) is a novel, water-soluble prosthetic group. It's radiochemistry has been developed and fully-automated for application in chemoselective radiolabelling of amino(oxy)-derivatised RI-OR2-TAT peptide, (Aoa-k)-RI-OR2-TAT, using a GE TRACERlab FX-FN. RI-OR2-TAT is a brain-penetrant, retro-inverso peptide that binds to amyloid species associated with Alzheimer's Disease. Radiolabelled (Aoa-k)-RI-OR2-TAT was reproducibly synthesised and the product of the reaction with FPCA has been fully characterised. In-vivo biodistribution of [18F]RI-OR2-TAT has been measured in Wistar rats.

KW - [18F]F prosthetic group

KW - PET

KW - Aβ peptide

KW - Chemical ligation

KW - Oxime bond

U2 - 10.1016/j.apradiso.2016.07.023

DO - 10.1016/j.apradiso.2016.07.023

M3 - Journal article

VL - 116

SP - 120

EP - 127

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

SN - 0969-8043

ER -