TY - JOUR

T1 - Development of collagen/PVA composites patches for osteochondral defects using a green processing of ionic liquid

AU - Iqbal, B.

AU - Muhammad, N.

AU - Rahim, A.

AU - Iqbal, F.

AU - Sharif, F.

AU - Safi, S.Z.

AU - Khan, A.S.

AU - Gonfa, G.

AU - Uroos, M.

AU - Rehman, I.U.

PY - 2019/5/1

Y1 - 2019/5/1

N2 - Osteochondral defects are still a big challenge for the surgeons because of good biocompatibility and higher mechanical strength requiring issues of the implants. In this study, different concentrations of collagen (dissolved in ionic liquid) up to 60% were blended with polyvinyl alcohol to prepare hydrogels of good mechanical strength, with the best biocompatibility and excellent fluid uptake ability. Ionic liquid was used as a green solvent for dissolution of collagen at a higher concentration as compared to other normal solvents. The prepared hydrogels were characterized with Fourier transform infrared spectroscopy (FTIR) which showed the characteristic peaks assigned to collagen and PVA. The surface morphology was investigated using scanning electron microscopy (SEM) which revealed homogeneity of the composite patches. Thermal gravimetric analysis (TGA) performed for samples show good thermal stabilities. Fluid uptake ability showed the massive uptake of fluid by the hydrogels. Biocompatibility was tested using hemolysis and MTT assay. Electrodynamic fatigue testing system was used for evaluating the mechanical properties and measured the tensile strength in the range of 2.4 to 8.5 MPa. The prepared osteochondral patches show good biocompatibility and mechanical properties. 

AB - Osteochondral defects are still a big challenge for the surgeons because of good biocompatibility and higher mechanical strength requiring issues of the implants. In this study, different concentrations of collagen (dissolved in ionic liquid) up to 60% were blended with polyvinyl alcohol to prepare hydrogels of good mechanical strength, with the best biocompatibility and excellent fluid uptake ability. Ionic liquid was used as a green solvent for dissolution of collagen at a higher concentration as compared to other normal solvents. The prepared hydrogels were characterized with Fourier transform infrared spectroscopy (FTIR) which showed the characteristic peaks assigned to collagen and PVA. The surface morphology was investigated using scanning electron microscopy (SEM) which revealed homogeneity of the composite patches. Thermal gravimetric analysis (TGA) performed for samples show good thermal stabilities. Fluid uptake ability showed the massive uptake of fluid by the hydrogels. Biocompatibility was tested using hemolysis and MTT assay. Electrodynamic fatigue testing system was used for evaluating the mechanical properties and measured the tensile strength in the range of 2.4 to 8.5 MPa. The prepared osteochondral patches show good biocompatibility and mechanical properties. 

KW - Characterization

KW - collagen

KW - ionic liquid

KW - osteochondral patches

KW - PVA

KW - Biocompatibility

KW - Collagen

KW - Fatigue testing

KW - Fourier transform infrared spectroscopy

KW - Gravimetric analysis

KW - Hydrogels

KW - Ionic liquids

KW - Mechanical properties

KW - Scanning electron microscopy

KW - Tensile strength

KW - Tensile testing

KW - Thermogravimetric analysis

KW - Characteristic peaks

KW - Composite patches

KW - Fluid uptake

KW - Green processing

KW - Green solvents

KW - Osteochondral

KW - Osteochondral defects

KW - Thermal gravimetric analyses (TGA)

KW - Ionic strength

U2 - 10.1080/00914037.2018.1474358

DO - 10.1080/00914037.2018.1474358

M3 - Journal article

VL - 68

SP - 590

EP - 596

JO - International Journal of Polymeric Materials and Polymeric Biomaterials

JF - International Journal of Polymeric Materials and Polymeric Biomaterials

SN - 0091-4037

IS - 10

ER -