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Development of high-resolution real-time sub-ppb ethane spectroscopy and some pilot studies in life science.

Research output: Contribution to journalJournal article

Published

  • K. D. Skeldon
  • G. M. Gibson
  • C. A. Wyse
  • L. C. McMillan
  • S. D. Monk
  • C. Longbottom
  • M. J. Padgett
Journal publication date08/2005
JournalApplied Optics
Journal number22
Volume44
Number of pages10
Pages4712-4721
Original languageEnglish

Abstract

We describe a high-resolution real-time spectroscopy system targeted to ethane gas with sensitivity >= 70 ppt and response time from >= 0.7 s. The measurement technique is based on a mid-IR lead-salt laser passing through a Herriott cell through which a gas sample flows. We compare wavelength scanning and locked configurations and discuss their relative merits. The technology has been motivated by clinical breath testing applications, ethane being widely regarded as the most important breath biomarker for cell damage via free-radical-mediated oxidative attack. We discuss preliminary human and animal studies in which ultrasensitive real-time ethane detection offers new diagnostic and monitoring potential. (c) 2005 Optical Society of America.