Home > Research > Publications & Outputs > Di(2-ethylhexyl) phthalate induces apoptosis th...

Electronic data

  • 2016_ET_DEHP apoptosis in GC-2spd cells

    Rights statement: This is the peer reviewed version of the following article: Fu, G., Dai, J., Zhang, D., Zhu, L., Tang, X., Zhang, L., Zhou, T., Duan, P., Quan, C., Zhang, Z., Song, S. and Shi, Y. (2017), Di(2-ethylhexyl) phthalate induces apoptosis through mitochondrial pathway in GC-2spd cells. Environ. Toxicol., 32: 1055–1064. doi:10.1002/tox.22304 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/tox.22304/abstract This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.

    Accepted author manuscript, 1.38 MB, PDF document

    Available under license: CC BY-NC: Creative Commons Attribution-NonCommercial 4.0 International License

Links

Text available via DOI:

View graph of relations

Di(2-ethylhexyl) phthalate induces apoptosis through mitochondrial pathway in GC-2spd cells

Research output: Contribution to journalJournal article

Published

Standard

Di(2-ethylhexyl) phthalate induces apoptosis through mitochondrial pathway in GC-2spd cells. / Fu, Guoqing; Dai, Juan; Zhang, Dayi; Zhu, Lishan; Tang, Xiao; Zhang, Ling; Zhou, Ting; Duan, Peng; Quan, Chao; Zhang, Zhibing; Song, Shizhen; Shi, Yuqin.

In: Environmental Toxicology, Vol. 32, No. 3, 03.2017, p. 1055-1064.

Research output: Contribution to journalJournal article

Harvard

Fu, G, Dai, J, Zhang, D, Zhu, L, Tang, X, Zhang, L, Zhou, T, Duan, P, Quan, C, Zhang, Z, Song, S & Shi, Y 2017, 'Di(2-ethylhexyl) phthalate induces apoptosis through mitochondrial pathway in GC-2spd cells', Environmental Toxicology, vol. 32, no. 3, pp. 1055-1064. https://doi.org/10.1002/tox.22304

APA

Fu, G., Dai, J., Zhang, D., Zhu, L., Tang, X., Zhang, L., Zhou, T., Duan, P., Quan, C., Zhang, Z., Song, S., & Shi, Y. (2017). Di(2-ethylhexyl) phthalate induces apoptosis through mitochondrial pathway in GC-2spd cells. Environmental Toxicology, 32(3), 1055-1064. https://doi.org/10.1002/tox.22304

Vancouver

Fu G, Dai J, Zhang D, Zhu L, Tang X, Zhang L et al. Di(2-ethylhexyl) phthalate induces apoptosis through mitochondrial pathway in GC-2spd cells. Environmental Toxicology. 2017 Mar;32(3):1055-1064. https://doi.org/10.1002/tox.22304

Author

Fu, Guoqing ; Dai, Juan ; Zhang, Dayi ; Zhu, Lishan ; Tang, Xiao ; Zhang, Ling ; Zhou, Ting ; Duan, Peng ; Quan, Chao ; Zhang, Zhibing ; Song, Shizhen ; Shi, Yuqin. / Di(2-ethylhexyl) phthalate induces apoptosis through mitochondrial pathway in GC-2spd cells. In: Environmental Toxicology. 2017 ; Vol. 32, No. 3. pp. 1055-1064.

Bibtex

@article{eda40b9c919b4b098058ff1b73f39ebc,
title = "Di(2-ethylhexyl) phthalate induces apoptosis through mitochondrial pathway in GC-2spd cells",
abstract = "Di(2-ethylhexyl) phthalate (DEHP), a plasticizer of synthetic polymers, is a well-known endocrine disrupting chemical (EDC) and reproductive toxicant. Addressing the unclear mechanism of DEHP-induced reproductive dysfunction, this study used GC-2spd cells to investigate the molecular mechanism involved in the DEHP-induced toxicity in the male reproductive system. The results indicated that the apoptotic cell death was significantly induced by DEHP exposure over 100 μM. Furthermore, DEHP treatment could induce oxidative stress in GC-2spd cells involving in the decrease of superoxide dismutase (SOD) activity (200 μM) and glutathione peroxidase (GSH-Px) activity (50 and 100 μM). In addition, DEHP induction also caused the elevated ratios of Bax/Bcl-2, release of cytochrome c and decomposition of procaspase-3 and procaspase-9 in GC-2spd cells. Taken together, our work provided the evidence that DEHP exposure might induce apoptosis of GC-2spd cells via mitochondria pathway mediated by oxidative stress. {\textcopyright} 2016 Wiley Periodicals, Inc. Environ Toxicol, 2016.",
keywords = "Di(2-ethylhexyl) phthalate (DEHP), GC-2spd cells, oxidative stress, apoptosis, mitochondrial pathway",
author = "Guoqing Fu and Juan Dai and Dayi Zhang and Lishan Zhu and Xiao Tang and Ling Zhang and Ting Zhou and Peng Duan and Chao Quan and Zhibing Zhang and Shizhen Song and Yuqin Shi",
note = "This is the peer reviewed version of the following article: Fu, G., Dai, J., Zhang, D., Zhu, L., Tang, X., Zhang, L., Zhou, T., Duan, P., Quan, C., Zhang, Z., Song, S. and Shi, Y. (2017), Di(2-ethylhexyl) phthalate induces apoptosis through mitochondrial pathway in GC-2spd cells. Environ. Toxicol., 32: 1055–1064. doi:10.1002/tox.22304 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/tox.22304/abstract This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.",
year = "2017",
month = mar
doi = "10.1002/tox.22304",
language = "English",
volume = "32",
pages = "1055--1064",
journal = "Environmental Toxicology",
issn = "1520-4081",
publisher = "John Wiley and Sons Inc.",
number = "3",

}

RIS

TY - JOUR

T1 - Di(2-ethylhexyl) phthalate induces apoptosis through mitochondrial pathway in GC-2spd cells

AU - Fu, Guoqing

AU - Dai, Juan

AU - Zhang, Dayi

AU - Zhu, Lishan

AU - Tang, Xiao

AU - Zhang, Ling

AU - Zhou, Ting

AU - Duan, Peng

AU - Quan, Chao

AU - Zhang, Zhibing

AU - Song, Shizhen

AU - Shi, Yuqin

N1 - This is the peer reviewed version of the following article: Fu, G., Dai, J., Zhang, D., Zhu, L., Tang, X., Zhang, L., Zhou, T., Duan, P., Quan, C., Zhang, Z., Song, S. and Shi, Y. (2017), Di(2-ethylhexyl) phthalate induces apoptosis through mitochondrial pathway in GC-2spd cells. Environ. Toxicol., 32: 1055–1064. doi:10.1002/tox.22304 which has been published in final form at http://onlinelibrary.wiley.com/doi/10.1002/tox.22304/abstract This article may be used for non-commercial purposes in accordance With Wiley Terms and Conditions for self-archiving.

PY - 2017/3

Y1 - 2017/3

N2 - Di(2-ethylhexyl) phthalate (DEHP), a plasticizer of synthetic polymers, is a well-known endocrine disrupting chemical (EDC) and reproductive toxicant. Addressing the unclear mechanism of DEHP-induced reproductive dysfunction, this study used GC-2spd cells to investigate the molecular mechanism involved in the DEHP-induced toxicity in the male reproductive system. The results indicated that the apoptotic cell death was significantly induced by DEHP exposure over 100 μM. Furthermore, DEHP treatment could induce oxidative stress in GC-2spd cells involving in the decrease of superoxide dismutase (SOD) activity (200 μM) and glutathione peroxidase (GSH-Px) activity (50 and 100 μM). In addition, DEHP induction also caused the elevated ratios of Bax/Bcl-2, release of cytochrome c and decomposition of procaspase-3 and procaspase-9 in GC-2spd cells. Taken together, our work provided the evidence that DEHP exposure might induce apoptosis of GC-2spd cells via mitochondria pathway mediated by oxidative stress. © 2016 Wiley Periodicals, Inc. Environ Toxicol, 2016.

AB - Di(2-ethylhexyl) phthalate (DEHP), a plasticizer of synthetic polymers, is a well-known endocrine disrupting chemical (EDC) and reproductive toxicant. Addressing the unclear mechanism of DEHP-induced reproductive dysfunction, this study used GC-2spd cells to investigate the molecular mechanism involved in the DEHP-induced toxicity in the male reproductive system. The results indicated that the apoptotic cell death was significantly induced by DEHP exposure over 100 μM. Furthermore, DEHP treatment could induce oxidative stress in GC-2spd cells involving in the decrease of superoxide dismutase (SOD) activity (200 μM) and glutathione peroxidase (GSH-Px) activity (50 and 100 μM). In addition, DEHP induction also caused the elevated ratios of Bax/Bcl-2, release of cytochrome c and decomposition of procaspase-3 and procaspase-9 in GC-2spd cells. Taken together, our work provided the evidence that DEHP exposure might induce apoptosis of GC-2spd cells via mitochondria pathway mediated by oxidative stress. © 2016 Wiley Periodicals, Inc. Environ Toxicol, 2016.

KW - Di(2-ethylhexyl) phthalate (DEHP)

KW - GC-2spd cells

KW - oxidative stress

KW - apoptosis

KW - mitochondrial pathway

U2 - 10.1002/tox.22304

DO - 10.1002/tox.22304

M3 - Journal article

C2 - 27416487

VL - 32

SP - 1055

EP - 1064

JO - Environmental Toxicology

JF - Environmental Toxicology

SN - 1520-4081

IS - 3

ER -