Differential effects of olanzapine and risperidone on cognition in schizophrenia? A saccadic eye movement study.

Psychology

Keywords

Schizophrenia • Risperidone • Olanzapine

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Published

Standard

Differential effects of olanzapine and risperidone on cognition in schizophrenia? A saccadic eye movement study. / Broerse, A.; Crawford, Trevor J.; Boer, J. A.
In: Journal of Neuropsychiatry and Clinical Neurosciences, Vol. 14, No. 4, 11.2002, p. 454-460.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Bibtex

@article{a8cf80bcfc82488b85cd2bb165308a1e,

title = "Differential effects of olanzapine and risperidone on cognition in schizophrenia? A saccadic eye movement study.",

abstract = "Recent studies suggest that novel antipsychotics have positive effects on certain cognitive functions in schizophrenia. The present study investigated this claim by means of saccadic paradigms, which provide a selective index of cognitive function. Thirty-three first-episode schizophrenic patients were randomly assigned to either olanzapine or risperidone treatment and compared with healthy control subjects for three saccadic paradigms. The influence of symptom profile, extrapyramidal symptoms, age, education, gender, hospitalization, and medication dose on cognitive performance was also investigated. Although the two patient groups did not differ from each other in task performance, both patient groups showed substantial problems in inhibitory control of saccades. A high level of education appeared to be protective for this impairment.",

keywords = "Schizophrenia • Risperidone • Olanzapine",

author = "A. Broerse and Crawford, {Trevor J.} and Boer, {J. A.}",

year = "2002",

month = nov,

language = "English",

volume = "14",

pages = "454--460",

journal = "Journal of Neuropsychiatry and Clinical Neurosciences",

issn = "0895-0172",

publisher = "American Psychiatric Publishing Inc.",

number = "4",

}

RIS

TY - JOUR

T1 - Differential effects of olanzapine and risperidone on cognition in schizophrenia? A saccadic eye movement study.

AU - Broerse, A.

AU - Crawford, Trevor J.

AU - Boer, J. A.

PY - 2002/11

Y1 - 2002/11

N2 - Recent studies suggest that novel antipsychotics have positive effects on certain cognitive functions in schizophrenia. The present study investigated this claim by means of saccadic paradigms, which provide a selective index of cognitive function. Thirty-three first-episode schizophrenic patients were randomly assigned to either olanzapine or risperidone treatment and compared with healthy control subjects for three saccadic paradigms. The influence of symptom profile, extrapyramidal symptoms, age, education, gender, hospitalization, and medication dose on cognitive performance was also investigated. Although the two patient groups did not differ from each other in task performance, both patient groups showed substantial problems in inhibitory control of saccades. A high level of education appeared to be protective for this impairment.

AB - Recent studies suggest that novel antipsychotics have positive effects on certain cognitive functions in schizophrenia. The present study investigated this claim by means of saccadic paradigms, which provide a selective index of cognitive function. Thirty-three first-episode schizophrenic patients were randomly assigned to either olanzapine or risperidone treatment and compared with healthy control subjects for three saccadic paradigms. The influence of symptom profile, extrapyramidal symptoms, age, education, gender, hospitalization, and medication dose on cognitive performance was also investigated. Although the two patient groups did not differ from each other in task performance, both patient groups showed substantial problems in inhibitory control of saccades. A high level of education appeared to be protective for this impairment.

KW - Schizophrenia • Risperidone • Olanzapine

M3 - Journal article

VL - 14

SP - 454

EP - 460

JO - Journal of Neuropsychiatry and Clinical Neurosciences

JF - Journal of Neuropsychiatry and Clinical Neurosciences

SN - 0895-0172

IS - 4

ER -

Research

Links

Keywords