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Differential gene expression in the peripheral zone compared to the transition zone of the human prostate gland.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Differential gene expression in the peripheral zone compared to the transition zone of the human prostate gland. / Noel, E. E.; Ragavan, N.; Walsh, Michael J. et al.
In: Prostate Cancer and Prostatic Diseases, Vol. 11, No. 2, 06.2008, p. 173-180.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Noel, EE, Ragavan, N, Walsh, MJ, James, SY, Matanhelia, SS, Nicholson, CM, Lu, Y-J & Martin, FL 2008, 'Differential gene expression in the peripheral zone compared to the transition zone of the human prostate gland.', Prostate Cancer and Prostatic Diseases, vol. 11, no. 2, pp. 173-180. https://doi.org/10.1038/sj.pcan.4500997

APA

Noel, E. E., Ragavan, N., Walsh, M. J., James, S. Y., Matanhelia, S. S., Nicholson, C. M., Lu, Y-J., & Martin, F. L. (2008). Differential gene expression in the peripheral zone compared to the transition zone of the human prostate gland. Prostate Cancer and Prostatic Diseases, 11(2), 173-180. https://doi.org/10.1038/sj.pcan.4500997

Vancouver

Noel EE, Ragavan N, Walsh MJ, James SY, Matanhelia SS, Nicholson CM et al. Differential gene expression in the peripheral zone compared to the transition zone of the human prostate gland. Prostate Cancer and Prostatic Diseases. 2008 Jun;11(2):173-180. doi: 10.1038/sj.pcan.4500997

Author

Noel, E. E. ; Ragavan, N. ; Walsh, Michael J. et al. / Differential gene expression in the peripheral zone compared to the transition zone of the human prostate gland. In: Prostate Cancer and Prostatic Diseases. 2008 ; Vol. 11, No. 2. pp. 173-180.

Bibtex

@article{c2c0182f7b4f47a3a0258eb0b663d8e0,
title = "Differential gene expression in the peripheral zone compared to the transition zone of the human prostate gland.",
abstract = "Gene expression profiles may lend insight into whether prostate adenocarcinoma (CaP) predominantly occurs in the peripheral zone (PZ) compared to the transition zone (TZ). From human prostates, tissue sets consisting of PZ and TZ were isolated to investigate whether there is a differential level of gene expression between these two regions of this gland. Gene expression profiling using Affymetrix Human Genome U133 plus 2.0 arrays coupled with quantitative real-time reverse transcriptase-PCR was employed. Genes associated with neurogenesis, signal transduction, embryo implantation and cell adhesion were found to be expressed at a higher level in the PZ. Those overexpressed in the TZ were associated with neurogenesis development, signal transduction, cell motility and development. Whether such differential gene expression profiles may identify molecular mechanisms responsible for susceptibility to CaP remains to be ascertained.",
keywords = "differential expression, oligonucleotide microarrays, prostate adenocarcinoma, peripheral zone, quantitative real-time RT-PCR, transition zone",
author = "Noel, {E. E.} and N. Ragavan and Walsh, {Michael J.} and James, {S. Y.} and Matanhelia, {S. S.} and Nicholson, {C. M.} and Y.-J. Lu and Martin, {Frank L.}",
year = "2008",
month = jun,
doi = "10.1038/sj.pcan.4500997",
language = "English",
volume = "11",
pages = "173--180",
journal = "Prostate Cancer and Prostatic Diseases",
issn = "1365-7852",
publisher = "Nature Publishing Group",
number = "2",

}

RIS

TY - JOUR

T1 - Differential gene expression in the peripheral zone compared to the transition zone of the human prostate gland.

AU - Noel, E. E.

AU - Ragavan, N.

AU - Walsh, Michael J.

AU - James, S. Y.

AU - Matanhelia, S. S.

AU - Nicholson, C. M.

AU - Lu, Y.-J.

AU - Martin, Frank L.

PY - 2008/6

Y1 - 2008/6

N2 - Gene expression profiles may lend insight into whether prostate adenocarcinoma (CaP) predominantly occurs in the peripheral zone (PZ) compared to the transition zone (TZ). From human prostates, tissue sets consisting of PZ and TZ were isolated to investigate whether there is a differential level of gene expression between these two regions of this gland. Gene expression profiling using Affymetrix Human Genome U133 plus 2.0 arrays coupled with quantitative real-time reverse transcriptase-PCR was employed. Genes associated with neurogenesis, signal transduction, embryo implantation and cell adhesion were found to be expressed at a higher level in the PZ. Those overexpressed in the TZ were associated with neurogenesis development, signal transduction, cell motility and development. Whether such differential gene expression profiles may identify molecular mechanisms responsible for susceptibility to CaP remains to be ascertained.

AB - Gene expression profiles may lend insight into whether prostate adenocarcinoma (CaP) predominantly occurs in the peripheral zone (PZ) compared to the transition zone (TZ). From human prostates, tissue sets consisting of PZ and TZ were isolated to investigate whether there is a differential level of gene expression between these two regions of this gland. Gene expression profiling using Affymetrix Human Genome U133 plus 2.0 arrays coupled with quantitative real-time reverse transcriptase-PCR was employed. Genes associated with neurogenesis, signal transduction, embryo implantation and cell adhesion were found to be expressed at a higher level in the PZ. Those overexpressed in the TZ were associated with neurogenesis development, signal transduction, cell motility and development. Whether such differential gene expression profiles may identify molecular mechanisms responsible for susceptibility to CaP remains to be ascertained.

KW - differential expression

KW - oligonucleotide microarrays

KW - prostate adenocarcinoma

KW - peripheral zone

KW - quantitative real-time RT-PCR

KW - transition zone

U2 - 10.1038/sj.pcan.4500997

DO - 10.1038/sj.pcan.4500997

M3 - Journal article

VL - 11

SP - 173

EP - 180

JO - Prostate Cancer and Prostatic Diseases

JF - Prostate Cancer and Prostatic Diseases

SN - 1365-7852

IS - 2

ER -