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Diversity of TMPRSS2-ERG fusion transcripts in the human prostate.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

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Diversity of TMPRSS2-ERG fusion transcripts in the human prostate. / Clark, J.; Merson, S.; Jhavar, S. et al.
In: Oncogene, Vol. 26, No. 18, 04.2007, p. 2667-2673.

Research output: Contribution to Journal/MagazineJournal articlepeer-review

Harvard

Clark, J, Merson, S, Jhavar, S, Flohr, P, Edwards, S, Foster, CS, Eeles, R, Martin, FL, Phillips, DH, Crundwell, M, Christmas, T, Thompson, A, Fisher, C, Kovacs, G & Cooper, CS 2007, 'Diversity of TMPRSS2-ERG fusion transcripts in the human prostate.', Oncogene, vol. 26, no. 18, pp. 2667-2673. https://doi.org/10.1038/sj.onc.1210070

APA

Clark, J., Merson, S., Jhavar, S., Flohr, P., Edwards, S., Foster, C. S., Eeles, R., Martin, F. L., Phillips, D. H., Crundwell, M., Christmas, T., Thompson, A., Fisher, C., Kovacs, G., & Cooper, C. S. (2007). Diversity of TMPRSS2-ERG fusion transcripts in the human prostate. Oncogene, 26(18), 2667-2673. https://doi.org/10.1038/sj.onc.1210070

Vancouver

Clark J, Merson S, Jhavar S, Flohr P, Edwards S, Foster CS et al. Diversity of TMPRSS2-ERG fusion transcripts in the human prostate. Oncogene. 2007 Apr;26(18):2667-2673. doi: 10.1038/sj.onc.1210070

Author

Clark, J. ; Merson, S. ; Jhavar, S. et al. / Diversity of TMPRSS2-ERG fusion transcripts in the human prostate. In: Oncogene. 2007 ; Vol. 26, No. 18. pp. 2667-2673.

Bibtex

@article{c6421964e1204962801a494c68659de7,
title = "Diversity of TMPRSS2-ERG fusion transcripts in the human prostate.",
abstract = "TMPRSS2-ERG gene fusions have recently been reported to be present in a high proportion of human prostate cancers. In the current study, we show that great diversity exists in the precise structure of TMPRSS2-ERG hybrid transcripts found in human prostates. Fourteen distinct hybrid transcripts are characterized, each containing different combinations of sequences from the TMPRSS2 and ERG genes. The transcripts include two that are predicted to encode a normal full-length ERG protein, six that encode N-terminal truncated ERG proteins and one that encodes a TMPRSS2-ERG fusion protein. Interestingly, distinct patterns of hybrid transcripts were found in samples taken from separate regions of individual cancer-containing prostates, suggesting that TMPRSS2-ERG gene fusions may be arising independently in different regions of a single prostate.",
keywords = "prostate cancer, ERG gene, TMPRSS2 gene, ERG fusion transcripts",
author = "J. Clark and S. Merson and S. Jhavar and P. Flohr and S. Edwards and Foster, {C. S.} and R. Eeles and Martin, {Frank L.} and Phillips, {D. H.} and M. Crundwell and T. Christmas and A. Thompson and C. Fisher and G. Kovacs and Cooper, {C. S.}",
year = "2007",
month = apr,
doi = "10.1038/sj.onc.1210070",
language = "English",
volume = "26",
pages = "2667--2673",
journal = "Oncogene",
issn = "0950-9232",
publisher = "Nature Publishing Group",
number = "18",

}

RIS

TY - JOUR

T1 - Diversity of TMPRSS2-ERG fusion transcripts in the human prostate.

AU - Clark, J.

AU - Merson, S.

AU - Jhavar, S.

AU - Flohr, P.

AU - Edwards, S.

AU - Foster, C. S.

AU - Eeles, R.

AU - Martin, Frank L.

AU - Phillips, D. H.

AU - Crundwell, M.

AU - Christmas, T.

AU - Thompson, A.

AU - Fisher, C.

AU - Kovacs, G.

AU - Cooper, C. S.

PY - 2007/4

Y1 - 2007/4

N2 - TMPRSS2-ERG gene fusions have recently been reported to be present in a high proportion of human prostate cancers. In the current study, we show that great diversity exists in the precise structure of TMPRSS2-ERG hybrid transcripts found in human prostates. Fourteen distinct hybrid transcripts are characterized, each containing different combinations of sequences from the TMPRSS2 and ERG genes. The transcripts include two that are predicted to encode a normal full-length ERG protein, six that encode N-terminal truncated ERG proteins and one that encodes a TMPRSS2-ERG fusion protein. Interestingly, distinct patterns of hybrid transcripts were found in samples taken from separate regions of individual cancer-containing prostates, suggesting that TMPRSS2-ERG gene fusions may be arising independently in different regions of a single prostate.

AB - TMPRSS2-ERG gene fusions have recently been reported to be present in a high proportion of human prostate cancers. In the current study, we show that great diversity exists in the precise structure of TMPRSS2-ERG hybrid transcripts found in human prostates. Fourteen distinct hybrid transcripts are characterized, each containing different combinations of sequences from the TMPRSS2 and ERG genes. The transcripts include two that are predicted to encode a normal full-length ERG protein, six that encode N-terminal truncated ERG proteins and one that encodes a TMPRSS2-ERG fusion protein. Interestingly, distinct patterns of hybrid transcripts were found in samples taken from separate regions of individual cancer-containing prostates, suggesting that TMPRSS2-ERG gene fusions may be arising independently in different regions of a single prostate.

KW - prostate cancer

KW - ERG gene

KW - TMPRSS2 gene

KW - ERG fusion transcripts

U2 - 10.1038/sj.onc.1210070

DO - 10.1038/sj.onc.1210070

M3 - Journal article

VL - 26

SP - 2667

EP - 2673

JO - Oncogene

JF - Oncogene

SN - 0950-9232

IS - 18

ER -