Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
}
TY - JOUR
T1 - Diversity of TMPRSS2-ERG fusion transcripts in the human prostate.
AU - Clark, J.
AU - Merson, S.
AU - Jhavar, S.
AU - Flohr, P.
AU - Edwards, S.
AU - Foster, C. S.
AU - Eeles, R.
AU - Martin, Frank L.
AU - Phillips, D. H.
AU - Crundwell, M.
AU - Christmas, T.
AU - Thompson, A.
AU - Fisher, C.
AU - Kovacs, G.
AU - Cooper, C. S.
PY - 2007/4
Y1 - 2007/4
N2 - TMPRSS2-ERG gene fusions have recently been reported to be present in a high proportion of human prostate cancers. In the current study, we show that great diversity exists in the precise structure of TMPRSS2-ERG hybrid transcripts found in human prostates. Fourteen distinct hybrid transcripts are characterized, each containing different combinations of sequences from the TMPRSS2 and ERG genes. The transcripts include two that are predicted to encode a normal full-length ERG protein, six that encode N-terminal truncated ERG proteins and one that encodes a TMPRSS2-ERG fusion protein. Interestingly, distinct patterns of hybrid transcripts were found in samples taken from separate regions of individual cancer-containing prostates, suggesting that TMPRSS2-ERG gene fusions may be arising independently in different regions of a single prostate.
AB - TMPRSS2-ERG gene fusions have recently been reported to be present in a high proportion of human prostate cancers. In the current study, we show that great diversity exists in the precise structure of TMPRSS2-ERG hybrid transcripts found in human prostates. Fourteen distinct hybrid transcripts are characterized, each containing different combinations of sequences from the TMPRSS2 and ERG genes. The transcripts include two that are predicted to encode a normal full-length ERG protein, six that encode N-terminal truncated ERG proteins and one that encodes a TMPRSS2-ERG fusion protein. Interestingly, distinct patterns of hybrid transcripts were found in samples taken from separate regions of individual cancer-containing prostates, suggesting that TMPRSS2-ERG gene fusions may be arising independently in different regions of a single prostate.
KW - prostate cancer
KW - ERG gene
KW - TMPRSS2 gene
KW - ERG fusion transcripts
U2 - 10.1038/sj.onc.1210070
DO - 10.1038/sj.onc.1210070
M3 - Journal article
VL - 26
SP - 2667
EP - 2673
JO - Oncogene
JF - Oncogene
SN - 0950-9232
IS - 18
ER -