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  • Taylor FO review 2016

    Accepted author manuscript, 452 KB, PDF-document

    Available under license: CC BY-NC: Creative Commons Attribution-NonCommercial 4.0 International License

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DNA replication stress and cancer: cause or cure?

Research output: Contribution to journalJournal article

Published
<mark>Journal publication date</mark>01/2016
<mark>Journal</mark>Future Oncology
Issue number2
Volume12
Number of pages17
Pages (from-to)221-237
Publication statusPublished
Original languageEnglish

Abstract

There is an extensive and growing body of evidence that DNA replication stress is a major driver in the development and progression of many cancers, and that these cancers rely heavily on replication stress response pathways for their continued proliferation. This raises the possibility that the pathways that ordinarily protect cells from the accumulation of cancer-causing mutations may actually prove to be effective therapeutic targets for a wide range of malignancies. In this review, we explore the mechanisms by which sustained proliferation can lead to replication stress and genome instability, and discuss how the pattern of mutations observed in human cancers is supportive of this oncogene-induced replication stress model. Finally, we go on to consider the implications of replication stress both as a prognostic indicator and, more encouragingly, as a potential target in cancer treatment.