Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Does phosphoenolpyruvate carboxykinase have a role in both amino acid and carbohydrate metabolism?
AU - Lea, P. J.
AU - Chen, Z.-H.
AU - Leegood, R. C.
AU - Walker, R. P.
PY - 2001/4
Y1 - 2001/4
N2 - Phosphoenolpyruvate carboxykinase (PEPCK) catalyses the reversible decarboxylation of oxaloacetate to yield phosphoenolpyruvate and CO2. The role of the enzyme in gluconeogenesis and anaplerotic reactions in a range of organisms is discussed, along with the important function in C4 and CAM photosynthesis in higher plants. In addition, new data are presented indicating that PEPCK may play a key role in amino acid metabolism. It is proposed that PEPCK is involved in the conversion of the carbon skeleton of asparagine/aspartate (oxaloacetate) to that of glutamate/glutamine (2-oxoglutarate). This metabolism is particularly important in the transport system, seeds and fruits of higher plants.
AB - Phosphoenolpyruvate carboxykinase (PEPCK) catalyses the reversible decarboxylation of oxaloacetate to yield phosphoenolpyruvate and CO2. The role of the enzyme in gluconeogenesis and anaplerotic reactions in a range of organisms is discussed, along with the important function in C4 and CAM photosynthesis in higher plants. In addition, new data are presented indicating that PEPCK may play a key role in amino acid metabolism. It is proposed that PEPCK is involved in the conversion of the carbon skeleton of asparagine/aspartate (oxaloacetate) to that of glutamate/glutamine (2-oxoglutarate). This metabolism is particularly important in the transport system, seeds and fruits of higher plants.
KW - Amino acid metabolism - Asparagine - Glutamate - Higher plants - Oxaloacetate - Phosphoenolpyruvate carboxykinase
U2 - 10.1007/s007260170041
DO - 10.1007/s007260170041
M3 - Journal article
VL - 20
SP - 225
EP - 241
JO - Amino Acids
JF - Amino Acids
SN - 0939-4451
IS - 3
ER -