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D-optimal designs for multiarm trials with dropouts

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<mark>Journal publication date</mark>1/07/2019
<mark>Journal</mark>Statistics in Medicine
Issue number15
Volume38
Number of pages18
Pages (from-to)2749-2766
Publication StatusPublished
Early online date25/03/19
<mark>Original language</mark>English

Abstract

Multiarm trials with follow-up on participants are commonly implemented to assess treatment effects on a population over the course of the studies. Dropout is an unavoidable issue especially when the duration of the multiarm study is long. Its impact is often ignored at the design stage, which may lead to less accurate statistical conclusions. We develop an optimal design framework for trials with repeated measurements, which takes potential dropouts into account, and we provide designs for linear mixed models where the presence of dropouts is noninformative and dependent on design variables. Our framework is illustrated through redesigning a clinical trial on Alzheimer's disease, whereby the benefits of our designs compared with standard designs are demonstrated through simulations. © 2019 The Authors. Statistics in Medicine Published by John Wiley & Sons Ltd.