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Drug orientations within statin-loaded lipoprotein nanoparticles by 19F solid-state NMR

Research output: Contribution to journalJournal article

Published
<mark>Journal publication date</mark>14/11/2019
<mark>Journal</mark>Chemical Communications
Issue number88
Volume55
Number of pages4
Pages (from-to)13287-13290
Publication statusPublished
Early online date14/10/19
Original languageEnglish

Abstract

NMR measurements of 19F chemical shift anisotropy and 1H-19F dipolar couplings provide unprecedented information on the molecular orientations of two fluorine-containing statin drugs within the heterogeneous environment of reconstituted high-density lipoprotein (rHDL) nanoparticles, a drug delivery system under clinical investigation.