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Research output: Contribution to Journal/Magazine › Journal article › peer-review
Research output: Contribution to Journal/Magazine › Journal article › peer-review
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TY - JOUR
T1 - Drug orientations within statin-loaded lipoprotein nanoparticles by 19F solid-state NMR
AU - Lau, Sophie
AU - Griffin, John
AU - Hughes, Eleri
AU - Middleton, David
PY - 2019/11/14
Y1 - 2019/11/14
N2 - NMR measurements of 19F chemical shift anisotropy and 1H-19F dipolar couplings provide unprecedented information on the molecular orientations of two fluorine-containing statin drugs within the heterogeneous environment of reconstituted high-density lipoprotein (rHDL) nanoparticles, a drug delivery system under clinical investigation.
AB - NMR measurements of 19F chemical shift anisotropy and 1H-19F dipolar couplings provide unprecedented information on the molecular orientations of two fluorine-containing statin drugs within the heterogeneous environment of reconstituted high-density lipoprotein (rHDL) nanoparticles, a drug delivery system under clinical investigation.
U2 - 10.1039/C9CC05344A
DO - 10.1039/C9CC05344A
M3 - Journal article
VL - 55
SP - 13287
EP - 13290
JO - Chemical Communications
JF - Chemical Communications
SN - 1359-7345
IS - 88
ER -