Accepted author manuscript, 394 KB, PDF document
Available under license: CC BY: Creative Commons Attribution 4.0 International License
Final published version
Licence: CC BY: Creative Commons Attribution 4.0 International License
Research output: Contribution to Journal/Magazine › Journal article › peer-review
<mark>Journal publication date</mark> | 14/01/2020 |
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<mark>Journal</mark> | Scandinavian Journal of Statistics |
Issue number | 2 |
Volume | 47 |
Number of pages | 15 |
Pages (from-to) | 572-586 |
Publication Status | E-pub ahead of print |
Early online date | 14/01/20 |
<mark>Original language</mark> | English |
The main contribution of this article is the verification of weak convergence of a general non-Markov (NM) state transition probability estimator by Titman, which has not yet been done for any other general NM estimator. A similar theorem is shown for the bootstrap, yielding resampling-based inference methods for statistical functionals. Formulas of the involved covariance functions are presented in detail. Particular applications include the conditional expected length of stay in a specific state, given occupation of another state in the past, and the construction of time-simultaneous confidence bands for the transition probabilities. The expected lengths of stay in a two-sample liver cirrhosis dataset are compared and confidence intervals for their difference are constructed. With borderline significance and in comparison to the placebo group, the treatment group has an elevated expected length of stay in the healthy state given an earlier disease state occupation. In contrast, the Aalen-Johansen (AJ) estimator-based confidence interval, which relies on a Markov assumption, leads to a drastically different conclusion. Also, graphical illustrations of confidence bands for the transition probabilities demonstrate the biasedness of the AJ estimator in this data example. The reliability of these results is assessed in a simulation study.