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Early senile plaques in Down's syndrome brains show a close relationship with cell bodies of neurons

Research output: Contribution to Journal/Magazine › Journal article › peer-review

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Early senile plaques in Down's syndrome brains show a close relationship with cell bodies of neurons. / Allsop, D; Haga, S I; Haga, C et al.
In: Neuropathology and Applied Neurobiology, Vol. 15, No. 6, 12.1990, p. 531-542.

Research output: Contribution to Journal/Magazine › Journal article › peer-review

Harvard

Allsop, D, Haga, SI, Haga, C, Ikeda, SI, Mann, DM & Ishii, T 1990, 'Early senile plaques in Down's syndrome brains show a close relationship with cell bodies of neurons', Neuropathology and Applied Neurobiology, vol. 15, no. 6, pp. 531-542. https://doi.org/10.1111/j.1365-2990.1989.tb01252.x

APA

Allsop, D., Haga, S. I., Haga, C., Ikeda, S. I., Mann, D. M., & Ishii, T. (1990). Early senile plaques in Down's syndrome brains show a close relationship with cell bodies of neurons. Neuropathology and Applied Neurobiology, 15(6), 531-542. https://doi.org/10.1111/j.1365-2990.1989.tb01252.x

Vancouver

Allsop D, Haga SI, Haga C, Ikeda SI, Mann DM, Ishii T. Early senile plaques in Down's syndrome brains show a close relationship with cell bodies of neurons. Neuropathology and Applied Neurobiology. 1990 Dec;15(6):531-542. doi: 10.1111/j.1365-2990.1989.tb01252.x

Author

Allsop, D ; Haga, S I ; Haga, C et al. / Early senile plaques in Down's syndrome brains show a close relationship with cell bodies of neurons. In: Neuropathology and Applied Neurobiology. 1990 ; Vol. 15, No. 6. pp. 531-542.

Bibtex

@article{82c0fffd0e72499d86196e9d49cc2a6f,
title = "Early senile plaques in Down's syndrome brains show a close relationship with cell bodies of neurons",
abstract = "A sensitive methenamine silver/Nissl stain was used to study the morphology and relationship of pre-plaques (presumed early senile plaques) in Down's syndrome brains to glial nuclei, capillaries and neuronal perikarya. The larger pre-plaques (greater than 50 microns) usually encompassed all of these tissue elements. However, the smaller pre-plaques (less than or equal to 50 microns) were almost always found immediately adjacent to, or around the cell bodies of neurons (often with associated satellite cells), and they failed to show any consistent, close spatial relationship to the other tissue components. Thus we consider an early stage of pre-plaque formation to be the deposition of amyloid adjacent to the cell body of a morphologically normal neuron. Based on the study of transitional forms, we suggest that the amyloid progressively accumulates around the cell body until the enclosed neuron degenerates. How these pre-plaque lesions might eventually develop into the typical plaque structure is uncertain. Our observations support the theory of a neuronal origin for plaque amyloid.",
keywords = "Adult, Amyloid, Amyloid beta-Peptides, Down Syndrome, Female, Humans, Immunohistochemistry, Inclusion Bodies, Male",
author = "D Allsop and Haga, {S I} and C Haga and Ikeda, {S I} and Mann, {D M} and T Ishii",
year = "1990",
month = dec,
doi = "10.1111/j.1365-2990.1989.tb01252.x",
language = "English",
volume = "15",
pages = "531--542",
journal = "Neuropathology and Applied Neurobiology",
issn = "0305-1846",
publisher = "Wiley-Blackwell",
number = "6",

}

RIS

TY - JOUR

T1 - Early senile plaques in Down's syndrome brains show a close relationship with cell bodies of neurons

AU - Allsop, D

AU - Haga, S I

AU - Haga, C

AU - Ikeda, S I

AU - Mann, D M

AU - Ishii, T

PY - 1990/12

Y1 - 1990/12

N2 - A sensitive methenamine silver/Nissl stain was used to study the morphology and relationship of pre-plaques (presumed early senile plaques) in Down's syndrome brains to glial nuclei, capillaries and neuronal perikarya. The larger pre-plaques (greater than 50 microns) usually encompassed all of these tissue elements. However, the smaller pre-plaques (less than or equal to 50 microns) were almost always found immediately adjacent to, or around the cell bodies of neurons (often with associated satellite cells), and they failed to show any consistent, close spatial relationship to the other tissue components. Thus we consider an early stage of pre-plaque formation to be the deposition of amyloid adjacent to the cell body of a morphologically normal neuron. Based on the study of transitional forms, we suggest that the amyloid progressively accumulates around the cell body until the enclosed neuron degenerates. How these pre-plaque lesions might eventually develop into the typical plaque structure is uncertain. Our observations support the theory of a neuronal origin for plaque amyloid.

AB - A sensitive methenamine silver/Nissl stain was used to study the morphology and relationship of pre-plaques (presumed early senile plaques) in Down's syndrome brains to glial nuclei, capillaries and neuronal perikarya. The larger pre-plaques (greater than 50 microns) usually encompassed all of these tissue elements. However, the smaller pre-plaques (less than or equal to 50 microns) were almost always found immediately adjacent to, or around the cell bodies of neurons (often with associated satellite cells), and they failed to show any consistent, close spatial relationship to the other tissue components. Thus we consider an early stage of pre-plaque formation to be the deposition of amyloid adjacent to the cell body of a morphologically normal neuron. Based on the study of transitional forms, we suggest that the amyloid progressively accumulates around the cell body until the enclosed neuron degenerates. How these pre-plaque lesions might eventually develop into the typical plaque structure is uncertain. Our observations support the theory of a neuronal origin for plaque amyloid.

KW - Adult

KW - Amyloid

KW - Amyloid beta-Peptides

KW - Down Syndrome

KW - Female

KW - Humans

KW - Immunohistochemistry

KW - Inclusion Bodies

KW - Male

U2 - 10.1111/j.1365-2990.1989.tb01252.x

DO - 10.1111/j.1365-2990.1989.tb01252.x

M3 - Journal article

C2 - 2559339

VL - 15

SP - 531

EP - 542

JO - Neuropathology and Applied Neurobiology

JF - Neuropathology and Applied Neurobiology

SN - 0305-1846

IS - 6

ER -